Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo
We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an am...
Published in: | Nature |
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2010
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Online Access: | https://orbit.dtu.dk/en/publications/23bafe64-7ff8-4c9d-b476-1e0b8c608f0b https://doi.org/10.1038/nature08835 |
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ftdtupubl:oai:pure.atira.dk:publications/23bafe64-7ff8-4c9d-b476-1e0b8c608f0b 2024-05-19T07:39:48+00:00 Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jacob Skov Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek dos Santos, Marcelo Bertalan Quintanilha Nielsen, Kasper Gilbert, MTP Wang, Y Raghavan, M Campos, PF Kamp, HM Wilson, AS Gledhill, A Tridico, S Bunce, M Lorenzen, ED Binladen, J Guo, X Zhao, J Zhang, X Zhang, H Li, Z Chen, M Orlando, L Kristiansen, K Bak, M Tommerup, N Bendixen, C Pierre, TL Grønnow, B Meldgaard, M Andreasen, C Fedorova, SA Osipova, LP Higham, TFG Ramsey, CB Hansen, TV Nielsen, FC Crawford, MH Brunak, Søren Sicheritz-Pontén, Thomas Villems, R Nielsen, R Krogh, A Wang, J Willerslev, E 2010 https://orbit.dtu.dk/en/publications/23bafe64-7ff8-4c9d-b476-1e0b8c608f0b https://doi.org/10.1038/nature08835 eng eng https://orbit.dtu.dk/en/publications/23bafe64-7ff8-4c9d-b476-1e0b8c608f0b info:eu-repo/semantics/restrictedAccess Rasmussen , M , Li , Y , Lindgreen , S , Pedersen , J S , Albrechtsen , A , Moltke , I , Metspalu , M , Metspalu , E , Kivisild , T , Gupta , R , dos Santos , M B Q , Nielsen , K , Gilbert , MTP , Wang , Y , Raghavan , M , Campos , PF , Kamp , HM , Wilson , AS , Gledhill , A , Tridico , S , Bunce , M , Lorenzen , ED , Binladen , J , Guo , X , Zhao , J , Zhang , X , Zhang , H , Li , Z , Chen , M , Orlando , L , Kristiansen , K , Bak , M , Tommerup , N , Bendixen , C , Pierre , TL , Grønnow , B , Meldgaard , M , Andreasen , C , Fedorova , SA , Osipova , LP , Higham , TFG , Ramsey , CB , Hansen , TV , Nielsen , FC , Crawford , MH , Brunak , S , Sicheritz-Pontén , T , Villems , R , Nielsen , R , Krogh , A , Wang , J & Willerslev , E 2010 , ' Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo ' , Nature , vol. 463 , no. 7282 , pp. 757-762 . https://doi.org/10.1038/nature08835 article 2010 ftdtupubl https://doi.org/10.1038/nature08835 2024-04-24T00:28:05Z We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. Article in Journal/Newspaper eskimo* Greenland inuit permafrost Siberia Technical University of Denmark: DTU Orbit Nature 463 7282 757 762 |
institution |
Open Polar |
collection |
Technical University of Denmark: DTU Orbit |
op_collection_id |
ftdtupubl |
language |
English |
description |
We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. |
format |
Article in Journal/Newspaper |
author |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jacob Skov Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek dos Santos, Marcelo Bertalan Quintanilha Nielsen, Kasper Gilbert, MTP Wang, Y Raghavan, M Campos, PF Kamp, HM Wilson, AS Gledhill, A Tridico, S Bunce, M Lorenzen, ED Binladen, J Guo, X Zhao, J Zhang, X Zhang, H Li, Z Chen, M Orlando, L Kristiansen, K Bak, M Tommerup, N Bendixen, C Pierre, TL Grønnow, B Meldgaard, M Andreasen, C Fedorova, SA Osipova, LP Higham, TFG Ramsey, CB Hansen, TV Nielsen, FC Crawford, MH Brunak, Søren Sicheritz-Pontén, Thomas Villems, R Nielsen, R Krogh, A Wang, J Willerslev, E |
spellingShingle |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jacob Skov Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek dos Santos, Marcelo Bertalan Quintanilha Nielsen, Kasper Gilbert, MTP Wang, Y Raghavan, M Campos, PF Kamp, HM Wilson, AS Gledhill, A Tridico, S Bunce, M Lorenzen, ED Binladen, J Guo, X Zhao, J Zhang, X Zhang, H Li, Z Chen, M Orlando, L Kristiansen, K Bak, M Tommerup, N Bendixen, C Pierre, TL Grønnow, B Meldgaard, M Andreasen, C Fedorova, SA Osipova, LP Higham, TFG Ramsey, CB Hansen, TV Nielsen, FC Crawford, MH Brunak, Søren Sicheritz-Pontén, Thomas Villems, R Nielsen, R Krogh, A Wang, J Willerslev, E Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo |
author_facet |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jacob Skov Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek dos Santos, Marcelo Bertalan Quintanilha Nielsen, Kasper Gilbert, MTP Wang, Y Raghavan, M Campos, PF Kamp, HM Wilson, AS Gledhill, A Tridico, S Bunce, M Lorenzen, ED Binladen, J Guo, X Zhao, J Zhang, X Zhang, H Li, Z Chen, M Orlando, L Kristiansen, K Bak, M Tommerup, N Bendixen, C Pierre, TL Grønnow, B Meldgaard, M Andreasen, C Fedorova, SA Osipova, LP Higham, TFG Ramsey, CB Hansen, TV Nielsen, FC Crawford, MH Brunak, Søren Sicheritz-Pontén, Thomas Villems, R Nielsen, R Krogh, A Wang, J Willerslev, E |
author_sort |
Rasmussen, Morten |
title |
Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo |
title_short |
Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo |
title_full |
Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo |
title_fullStr |
Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo |
title_full_unstemmed |
Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo |
title_sort |
ancient human genome sequence of an extinct palaeo-eskimo |
publishDate |
2010 |
url |
https://orbit.dtu.dk/en/publications/23bafe64-7ff8-4c9d-b476-1e0b8c608f0b https://doi.org/10.1038/nature08835 |
genre |
eskimo* Greenland inuit permafrost Siberia |
genre_facet |
eskimo* Greenland inuit permafrost Siberia |
op_source |
Rasmussen , M , Li , Y , Lindgreen , S , Pedersen , J S , Albrechtsen , A , Moltke , I , Metspalu , M , Metspalu , E , Kivisild , T , Gupta , R , dos Santos , M B Q , Nielsen , K , Gilbert , MTP , Wang , Y , Raghavan , M , Campos , PF , Kamp , HM , Wilson , AS , Gledhill , A , Tridico , S , Bunce , M , Lorenzen , ED , Binladen , J , Guo , X , Zhao , J , Zhang , X , Zhang , H , Li , Z , Chen , M , Orlando , L , Kristiansen , K , Bak , M , Tommerup , N , Bendixen , C , Pierre , TL , Grønnow , B , Meldgaard , M , Andreasen , C , Fedorova , SA , Osipova , LP , Higham , TFG , Ramsey , CB , Hansen , TV , Nielsen , FC , Crawford , MH , Brunak , S , Sicheritz-Pontén , T , Villems , R , Nielsen , R , Krogh , A , Wang , J & Willerslev , E 2010 , ' Ancient Human Genome Sequence of an Extinct Palaeo-Eskimo ' , Nature , vol. 463 , no. 7282 , pp. 757-762 . https://doi.org/10.1038/nature08835 |
op_relation |
https://orbit.dtu.dk/en/publications/23bafe64-7ff8-4c9d-b476-1e0b8c608f0b |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1038/nature08835 |
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Nature |
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463 |
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7282 |
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757 |
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