Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year
Vitamin D and 25-hydroxyvitamin D (25(OH)D) are stored in adipose tissue, but the clinical relevance is uncertain. To evaluate changes in serum 25(OH)D and adipose tissue vitamin D levels, after stopping vitamin D supplementation. A prospective, double-blind cohort follow-up study. Clinical Research...
Published in: | The Journal of Clinical Endocrinology & Metabolism |
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ftdtupubl:oai:pure.atira.dk:publications/1c830625-788c-42a2-bb56-6eede08d5ae3 2024-04-28T08:31:56+00:00 Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year Martinaityte, Ieva Kamycheva, Elena Didriksen, Allan Jakobsen, Jette Jorde, Rolf 2017 https://orbit.dtu.dk/en/publications/1c830625-788c-42a2-bb56-6eede08d5ae3 https://doi.org/10.1210/jc.2017-01187 eng eng https://orbit.dtu.dk/en/publications/1c830625-788c-42a2-bb56-6eede08d5ae3 info:eu-repo/semantics/closedAccess Martinaityte , I , Kamycheva , E , Didriksen , A , Jakobsen , J & Jorde , R 2017 , ' Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year ' , Endocrinology , vol. 102 , no. 10 , pp. 3731-3738 . https://doi.org/10.1210/jc.2017-01187 /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2017 ftdtupubl https://doi.org/10.1210/jc.2017-01187 2024-04-03T15:29:59Z Vitamin D and 25-hydroxyvitamin D (25(OH)D) are stored in adipose tissue, but the clinical relevance is uncertain. To evaluate changes in serum 25(OH)D and adipose tissue vitamin D levels, after stopping vitamin D supplementation. A prospective, double-blind cohort follow-up study. Clinical Research Unit at The University Hospital of North Norway. 76 subjects were included after participation in a 3-5 year prevention of type 2 diabetes study, and were administered 20,000 IU of vitamin D or placebo / week. During the 12-month follow-up period, blood samples were drawn at the beginning and after one, three, six, nine, and 12 months. Fat biopsies were taken at the start and end. Changes in 25(OH)D level in serum, and 25(OH)D and vitamin D levels in adipose tissue. 41 out of 42 subjects who had been given vitamin D, and 33 out of 34 subjects who were given the placebo completed the study. At the inclusion mean serum 25(OH)D levels were 122 and 71 nmol/L in vitamin D and placebo groups, respectively. Serum 25(OH)D remained significantly higher in the vitamin D group compared to the placebo group throughout, and was 84.5 and 73.1 nmol/L, respectively after 12 months. In the vitamin D group, adipose tissue vitamin D levels decreased by 52% over 12 months. 25(OH)D and vitamin D stored in adipose tissue after 3-5 years with vitamin D supplementation may have a clinically relevant effect on serum 25(OH)D levels the following year. Article in Journal/Newspaper North Norway Technical University of Denmark: DTU Orbit The Journal of Clinical Endocrinology & Metabolism 102 10 3731 3738 |
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Open Polar |
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Technical University of Denmark: DTU Orbit |
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English |
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/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
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/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Martinaityte, Ieva Kamycheva, Elena Didriksen, Allan Jakobsen, Jette Jorde, Rolf Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year |
topic_facet |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
Vitamin D and 25-hydroxyvitamin D (25(OH)D) are stored in adipose tissue, but the clinical relevance is uncertain. To evaluate changes in serum 25(OH)D and adipose tissue vitamin D levels, after stopping vitamin D supplementation. A prospective, double-blind cohort follow-up study. Clinical Research Unit at The University Hospital of North Norway. 76 subjects were included after participation in a 3-5 year prevention of type 2 diabetes study, and were administered 20,000 IU of vitamin D or placebo / week. During the 12-month follow-up period, blood samples were drawn at the beginning and after one, three, six, nine, and 12 months. Fat biopsies were taken at the start and end. Changes in 25(OH)D level in serum, and 25(OH)D and vitamin D levels in adipose tissue. 41 out of 42 subjects who had been given vitamin D, and 33 out of 34 subjects who were given the placebo completed the study. At the inclusion mean serum 25(OH)D levels were 122 and 71 nmol/L in vitamin D and placebo groups, respectively. Serum 25(OH)D remained significantly higher in the vitamin D group compared to the placebo group throughout, and was 84.5 and 73.1 nmol/L, respectively after 12 months. In the vitamin D group, adipose tissue vitamin D levels decreased by 52% over 12 months. 25(OH)D and vitamin D stored in adipose tissue after 3-5 years with vitamin D supplementation may have a clinically relevant effect on serum 25(OH)D levels the following year. |
format |
Article in Journal/Newspaper |
author |
Martinaityte, Ieva Kamycheva, Elena Didriksen, Allan Jakobsen, Jette Jorde, Rolf |
author_facet |
Martinaityte, Ieva Kamycheva, Elena Didriksen, Allan Jakobsen, Jette Jorde, Rolf |
author_sort |
Martinaityte, Ieva |
title |
Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year |
title_short |
Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year |
title_full |
Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year |
title_fullStr |
Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year |
title_full_unstemmed |
Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year |
title_sort |
vitamin d stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin d levels the following year |
publishDate |
2017 |
url |
https://orbit.dtu.dk/en/publications/1c830625-788c-42a2-bb56-6eede08d5ae3 https://doi.org/10.1210/jc.2017-01187 |
genre |
North Norway |
genre_facet |
North Norway |
op_source |
Martinaityte , I , Kamycheva , E , Didriksen , A , Jakobsen , J & Jorde , R 2017 , ' Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year ' , Endocrinology , vol. 102 , no. 10 , pp. 3731-3738 . https://doi.org/10.1210/jc.2017-01187 |
op_relation |
https://orbit.dtu.dk/en/publications/1c830625-788c-42a2-bb56-6eede08d5ae3 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1210/jc.2017-01187 |
container_title |
The Journal of Clinical Endocrinology & Metabolism |
container_volume |
102 |
container_issue |
10 |
container_start_page |
3731 |
op_container_end_page |
3738 |
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1797589278144856064 |