Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection
DNA vaccines encoding the glycoprotein genes of the salmonid rhabdoviruses VHSV and IHNV are very efficient in eliciting protective immune responses against their respective diseases in rainbow trout (Oncorhynchus mykiss). The early anti-viral response (EAVR) provides Protection by 4 days post vacci...
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2009
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ftdtupubl:oai:pure.atira.dk:publications/0da23a9d-5124-45dd-8dc1-7fb3dfc3e3bb 2023-09-05T13:18:13+02:00 Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection Einer-Jensen, Katja Delgado, L. Lorenzen, Ellen Bovo, G. Evensen, Ø. LaPatra, S. Lorenzen, Niels 2009 https://orbit.dtu.dk/en/publications/0da23a9d-5124-45dd-8dc1-7fb3dfc3e3bb https://doi.org/10.1016/j.vaccine.2008.12.007 eng eng info:eu-repo/semantics/restrictedAccess Einer-Jensen , K , Delgado , L , Lorenzen , E , Bovo , G , Evensen , Ø , LaPatra , S & Lorenzen , N 2009 , ' Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection ' , Vaccine , vol. 27 , no. 8 , pp. 1248-1253 . https://doi.org/10.1016/j.vaccine.2008.12.007 Immunology of protection Disease prevention Animal model /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being SDG 3 - Good Health and Well-being article 2009 ftdtupubl https://doi.org/10.1016/j.vaccine.2008.12.007 2023-08-16T22:55:26Z DNA vaccines encoding the glycoprotein genes of the salmonid rhabdoviruses VHSV and IHNV are very efficient in eliciting protective immune responses against their respective diseases in rainbow trout (Oncorhynchus mykiss). The early anti-viral response (EAVR) provides Protection by 4 days post vaccination and is non-specific and transient while the specific anti-viral response (SAVR) is long lasting and highly specific. Since both VHSV and IHNV are endemic in rainbow trout in several geographical regions of Europe and Atlantic salmon (Salmo salar) on the Pacific coast of North America, co-vaccination against the two diseases would be a preferable option. In the present study we demonstrated that a single injection of mixed DNA vaccines induced long-lasting protection against both individual and a simultaneous virus challenge 80 days post vaccination. Transfected muscle cells at the injection site expressed both G proteins. This study confirms the applied potential Of using a combined DNA vaccination for protection of fish against two different rhabdoviral diseases. Article in Journal/Newspaper Atlantic salmon Salmo salar Technical University of Denmark: DTU Orbit Pacific Vaccine 27 8 1248 1253 |
institution |
Open Polar |
collection |
Technical University of Denmark: DTU Orbit |
op_collection_id |
ftdtupubl |
language |
English |
topic |
Immunology of protection Disease prevention Animal model /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being SDG 3 - Good Health and Well-being |
spellingShingle |
Immunology of protection Disease prevention Animal model /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being SDG 3 - Good Health and Well-being Einer-Jensen, Katja Delgado, L. Lorenzen, Ellen Bovo, G. Evensen, Ø. LaPatra, S. Lorenzen, Niels Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection |
topic_facet |
Immunology of protection Disease prevention Animal model /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being SDG 3 - Good Health and Well-being |
description |
DNA vaccines encoding the glycoprotein genes of the salmonid rhabdoviruses VHSV and IHNV are very efficient in eliciting protective immune responses against their respective diseases in rainbow trout (Oncorhynchus mykiss). The early anti-viral response (EAVR) provides Protection by 4 days post vaccination and is non-specific and transient while the specific anti-viral response (SAVR) is long lasting and highly specific. Since both VHSV and IHNV are endemic in rainbow trout in several geographical regions of Europe and Atlantic salmon (Salmo salar) on the Pacific coast of North America, co-vaccination against the two diseases would be a preferable option. In the present study we demonstrated that a single injection of mixed DNA vaccines induced long-lasting protection against both individual and a simultaneous virus challenge 80 days post vaccination. Transfected muscle cells at the injection site expressed both G proteins. This study confirms the applied potential Of using a combined DNA vaccination for protection of fish against two different rhabdoviral diseases. |
format |
Article in Journal/Newspaper |
author |
Einer-Jensen, Katja Delgado, L. Lorenzen, Ellen Bovo, G. Evensen, Ø. LaPatra, S. Lorenzen, Niels |
author_facet |
Einer-Jensen, Katja Delgado, L. Lorenzen, Ellen Bovo, G. Evensen, Ø. LaPatra, S. Lorenzen, Niels |
author_sort |
Einer-Jensen, Katja |
title |
Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection |
title_short |
Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection |
title_full |
Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection |
title_fullStr |
Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection |
title_full_unstemmed |
Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection |
title_sort |
dual dna vaccination of rainbow trout (oncorhynchus mykiss) against two different rhabdoviruses, vhsv and ihnv, induces specific divalent protection |
publishDate |
2009 |
url |
https://orbit.dtu.dk/en/publications/0da23a9d-5124-45dd-8dc1-7fb3dfc3e3bb https://doi.org/10.1016/j.vaccine.2008.12.007 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Einer-Jensen , K , Delgado , L , Lorenzen , E , Bovo , G , Evensen , Ø , LaPatra , S & Lorenzen , N 2009 , ' Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection ' , Vaccine , vol. 27 , no. 8 , pp. 1248-1253 . https://doi.org/10.1016/j.vaccine.2008.12.007 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.vaccine.2008.12.007 |
container_title |
Vaccine |
container_volume |
27 |
container_issue |
8 |
container_start_page |
1248 |
op_container_end_page |
1253 |
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1776199227154628608 |