Relationship Between Changes in Serum Thyrotropin and Total and Lipoprotein Cholesterol with Prolonged Antarctic Residence

• Main Authors: Harford, R. R., Reed, H. L., Morris, M. T., Sapien, I. E., Warden, R.
• Other Authors: NAVAL MEDICAL RESEARCH INST BETHESDA MD
• Format: Text
• Language: English
• Published: 1993
• Subjects: Biochemistry; Medicine and Medical Research; *THYROTROPIN; *CHOLESTEROL; *LIPOPROTEINS; REPRINTS; ANTARCTIC REGIONS; CARDIOVASCULAR SYSTEM; THYROID GLAND; PE63706N; WU1008; TRIIODOTHYRONINE; AR(ANTARCTIC RESIDENCE); SERUM LIPID; Antarctic; Antarc*
• Online Access: http://www.dtic.mil/docs/citations/ADA274262; http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA274262

Antarctic residence (AR) is associated with a 50% increase in the thyrotropin (TSH) response to TSH-releasing hormone (TRH) and an expended triiodothyronine (T3) distribution volume and extravascular hormone pool, collectively called the polar T3 syndrome. To investigate the possible biologic significance of this syndrome, we studied the relationship between nonstimulated TSH and serum lipid profiles in nine subjects, once while in California and monthly during 9 months of AR. We measured serum levels of TSH, total thyroxine (TT4), free T4(FT4), total T3(TT3), free T3(FT3), thyroid-binding globulin (TBG) , total cholesterol (T-CHOL), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), dietary cholesterol (D-CHOL), dietary fat (D-FAT), and dietary kilocalories at each month. Pub. in Metabolism, v42 n9 p1159-1163, Sep 1993.