Molecular Studies of Alphavirus Immunogenicity.
Ockelbo virus, first isolated in 1982 in Sweden, causes arthritis, fever and rash in man. We have obtained the complete nucleotide sequence of Ockelbo virus and compared this sequence to that of other strains of Sindbis virus. Partial sequence analysis of five other strains of Sindbis virus was also...
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ftdtic:ADA239227 2023-05-15T15:00:34+02:00 Molecular Studies of Alphavirus Immunogenicity. Strauss, James H. CALIFORNIA INST OF TECH PASADENA 1991-05-01 text/html http://www.dtic.mil/docs/citations/ADA239227 http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA239227 en eng http://www.dtic.mil/docs/citations/ADA239227 Approved for public release; distribution is unlimited. DTIC AND NTIS Biochemistry Medicine and Medical Research Microbiology *SINDBIS VIRUS HUMANS MOLECULES DISEASES SEQUENCES TROPICAL REGIONS NORTH(DIRECTION) AFRICA VIRUSES ENCEPHALITIS PATHOGENIC MICROORGANISMS FEVERS SWEDEN ARCTIC REGIONS FINLAND ARTHRITIS SUBTROPICAL REGIONS NUCLEOTIDES USSR TIME INTERVALS PE61102A WU117 ASS12 WUDA346101 IMMUNOGENICITY IMMUNOGENS OCKELBO VIRUSES SINDBIS VIRUSES CAUSITIVE AGENTS CULICIDAE ALPHAVIRUSES PATHOGENS ANTIGENS POGOSTA DISEASE KARELIAN FEVER VIRUS DISEASES Text 1991 ftdtic 2016-02-22T21:27:27Z Ockelbo virus, first isolated in 1982 in Sweden, causes arthritis, fever and rash in man. We have obtained the complete nucleotide sequence of Ockelbo virus and compared this sequence to that of other strains of Sindbis virus. Partial sequence analysis of five other strains of Sindbis virus was also performed. Three principal conclusions arise from our data. (1) Ockelbo is virtually identical to the causitive agents of Karelian Fever of Russian and of Pogosta disease of Finland. (2) These agents are closely related to South African strains of Sindbis virus, and Ockelbo was probably introduced into northern Sweden from Africa in the 1960's, followed by spread to Russian and Finland. (3) There exist an European-African group of closely related Sindbis viruses and an Asian-Australian group of Sindbis viruses. The alphaviruses are a widespread group of human pathogens that are endemic and epidemic in many parts of the world. They are mosquito-borne and are particularly prevalent in tropical and subtropical areas of the world, but alphaviruses pathogenic for man are also present in temperature and even Arctic areas. Many alphaviruses are capable of causing fever, rash and arthralgia in man that in some cases can be disabling for extended periods of time. Many of the New World alphaviruses can cause encephalitis in man. We wish to determine the relationships of alphaviruses and strains of alphaviruses to one another and to search for emerging viruses. Text Arctic karelia* karelian Northern Sweden Defense Technical Information Center: DTIC Technical Reports database Arctic |
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Defense Technical Information Center: DTIC Technical Reports database |
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English |
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Biochemistry Medicine and Medical Research Microbiology *SINDBIS VIRUS HUMANS MOLECULES DISEASES SEQUENCES TROPICAL REGIONS NORTH(DIRECTION) AFRICA VIRUSES ENCEPHALITIS PATHOGENIC MICROORGANISMS FEVERS SWEDEN ARCTIC REGIONS FINLAND ARTHRITIS SUBTROPICAL REGIONS NUCLEOTIDES USSR TIME INTERVALS PE61102A WU117 ASS12 WUDA346101 IMMUNOGENICITY IMMUNOGENS OCKELBO VIRUSES SINDBIS VIRUSES CAUSITIVE AGENTS CULICIDAE ALPHAVIRUSES PATHOGENS ANTIGENS POGOSTA DISEASE KARELIAN FEVER VIRUS DISEASES |
spellingShingle |
Biochemistry Medicine and Medical Research Microbiology *SINDBIS VIRUS HUMANS MOLECULES DISEASES SEQUENCES TROPICAL REGIONS NORTH(DIRECTION) AFRICA VIRUSES ENCEPHALITIS PATHOGENIC MICROORGANISMS FEVERS SWEDEN ARCTIC REGIONS FINLAND ARTHRITIS SUBTROPICAL REGIONS NUCLEOTIDES USSR TIME INTERVALS PE61102A WU117 ASS12 WUDA346101 IMMUNOGENICITY IMMUNOGENS OCKELBO VIRUSES SINDBIS VIRUSES CAUSITIVE AGENTS CULICIDAE ALPHAVIRUSES PATHOGENS ANTIGENS POGOSTA DISEASE KARELIAN FEVER VIRUS DISEASES Strauss, James H. Molecular Studies of Alphavirus Immunogenicity. |
topic_facet |
Biochemistry Medicine and Medical Research Microbiology *SINDBIS VIRUS HUMANS MOLECULES DISEASES SEQUENCES TROPICAL REGIONS NORTH(DIRECTION) AFRICA VIRUSES ENCEPHALITIS PATHOGENIC MICROORGANISMS FEVERS SWEDEN ARCTIC REGIONS FINLAND ARTHRITIS SUBTROPICAL REGIONS NUCLEOTIDES USSR TIME INTERVALS PE61102A WU117 ASS12 WUDA346101 IMMUNOGENICITY IMMUNOGENS OCKELBO VIRUSES SINDBIS VIRUSES CAUSITIVE AGENTS CULICIDAE ALPHAVIRUSES PATHOGENS ANTIGENS POGOSTA DISEASE KARELIAN FEVER VIRUS DISEASES |
description |
Ockelbo virus, first isolated in 1982 in Sweden, causes arthritis, fever and rash in man. We have obtained the complete nucleotide sequence of Ockelbo virus and compared this sequence to that of other strains of Sindbis virus. Partial sequence analysis of five other strains of Sindbis virus was also performed. Three principal conclusions arise from our data. (1) Ockelbo is virtually identical to the causitive agents of Karelian Fever of Russian and of Pogosta disease of Finland. (2) These agents are closely related to South African strains of Sindbis virus, and Ockelbo was probably introduced into northern Sweden from Africa in the 1960's, followed by spread to Russian and Finland. (3) There exist an European-African group of closely related Sindbis viruses and an Asian-Australian group of Sindbis viruses. The alphaviruses are a widespread group of human pathogens that are endemic and epidemic in many parts of the world. They are mosquito-borne and are particularly prevalent in tropical and subtropical areas of the world, but alphaviruses pathogenic for man are also present in temperature and even Arctic areas. Many alphaviruses are capable of causing fever, rash and arthralgia in man that in some cases can be disabling for extended periods of time. Many of the New World alphaviruses can cause encephalitis in man. We wish to determine the relationships of alphaviruses and strains of alphaviruses to one another and to search for emerging viruses. |
author2 |
CALIFORNIA INST OF TECH PASADENA |
format |
Text |
author |
Strauss, James H. |
author_facet |
Strauss, James H. |
author_sort |
Strauss, James H. |
title |
Molecular Studies of Alphavirus Immunogenicity. |
title_short |
Molecular Studies of Alphavirus Immunogenicity. |
title_full |
Molecular Studies of Alphavirus Immunogenicity. |
title_fullStr |
Molecular Studies of Alphavirus Immunogenicity. |
title_full_unstemmed |
Molecular Studies of Alphavirus Immunogenicity. |
title_sort |
molecular studies of alphavirus immunogenicity. |
publishDate |
1991 |
url |
http://www.dtic.mil/docs/citations/ADA239227 http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA239227 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic karelia* karelian Northern Sweden |
genre_facet |
Arctic karelia* karelian Northern Sweden |
op_source |
DTIC AND NTIS |
op_relation |
http://www.dtic.mil/docs/citations/ADA239227 |
op_rights |
Approved for public release; distribution is unlimited. |
_version_ |
1766332656243441664 |