Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis)
Background: The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene...
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ftdryad:oai:v1.datadryad.org:10255/dryad.99974 2023-05-15T18:50:19+02:00 Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) Prentice, Melanie B. Bowman, Jeff Wilson, Paul J. Canada Holocene 2015-10-29T16:43:18Z http://hdl.handle.net/10255/dryad.99974 https://doi.org/10.5061/dryad.h43c1 unknown doi:10.5061/dryad.h43c1/1 doi:10.1186/s12863-015-0284-y PMID:26503624 doi:10.5061/dryad.h43c1 Prentice MB, Bowman J, Wilson PJ (2015) A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis). BMC Genetics 16: 125. http://hdl.handle.net/10255/dryad.99974 somatic mosaicism androgen receptor Canada lynx trinucleotide repeats Article 2015 ftdryad https://doi.org/10.5061/dryad.h43c1 https://doi.org/10.5061/dryad.h43c1/1 https://doi.org/10.1186/s12863-015-0284-y 2020-01-01T15:26:07Z Background: The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (Lynx lynx). We investigated this claim in a closely related species, Canada lynx (Lynx canadensis). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods: To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results: We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions: Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. Article in Journal/Newspaper Lynx Lynx lynx lynx Dryad Digital Repository (Duke University) Canada |
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Dryad Digital Repository (Duke University) |
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topic |
somatic mosaicism androgen receptor Canada lynx trinucleotide repeats |
spellingShingle |
somatic mosaicism androgen receptor Canada lynx trinucleotide repeats Prentice, Melanie B. Bowman, Jeff Wilson, Paul J. Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
topic_facet |
somatic mosaicism androgen receptor Canada lynx trinucleotide repeats |
description |
Background: The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (Lynx lynx). We investigated this claim in a closely related species, Canada lynx (Lynx canadensis). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods: To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results: We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions: Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. |
format |
Article in Journal/Newspaper |
author |
Prentice, Melanie B. Bowman, Jeff Wilson, Paul J. |
author_facet |
Prentice, Melanie B. Bowman, Jeff Wilson, Paul J. |
author_sort |
Prentice, Melanie B. |
title |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_short |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_full |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_fullStr |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_full_unstemmed |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_sort |
data from: a test of somatic mosaicism in the androgen receptor gene of canada lynx (lynx canadensis) |
publishDate |
2015 |
url |
http://hdl.handle.net/10255/dryad.99974 https://doi.org/10.5061/dryad.h43c1 |
op_coverage |
Canada Holocene |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Lynx Lynx lynx lynx |
genre_facet |
Lynx Lynx lynx lynx |
op_relation |
doi:10.5061/dryad.h43c1/1 doi:10.1186/s12863-015-0284-y PMID:26503624 doi:10.5061/dryad.h43c1 Prentice MB, Bowman J, Wilson PJ (2015) A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis). BMC Genetics 16: 125. http://hdl.handle.net/10255/dryad.99974 |
op_doi |
https://doi.org/10.5061/dryad.h43c1 https://doi.org/10.5061/dryad.h43c1/1 https://doi.org/10.1186/s12863-015-0284-y |
_version_ |
1766244035106701312 |