Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar)
Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an import...
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ftdryad:oai:v1.datadryad.org:10255/dryad.83922 2023-05-15T15:30:24+02:00 Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) Gonen, Serap Baranski, Matthew Thorland, Ingunn Norris, Ashie Grove, Harald Arnesen, Petter Bakke, Håvard Lien, Sigbjørn Bishop, Stephen C. Houston, Ross D. 2015-03-31T15:05:58Z http://hdl.handle.net/10255/dryad.83922 https://doi.org/10.5061/dryad.5241h unknown doi:10.5061/dryad.5241h/1 doi:10.1038/hdy.2015.37 PMID:25990876 doi:10.5061/dryad.5241h Gonen S, Baranski M, Thorland I, Norris A, Grove H, Arnesen P, Bakke H, Lien S, Bishop SC, Houston RD (2015) Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar). Heredity 115: 405–414. http://hdl.handle.net/10255/dryad.83922 Atlantic salmon Pancreas disease Salmonid alphavirus QTL mapping Genetic variation Disease resistance Article 2015 ftdryad https://doi.org/10.5061/dryad.5241h https://doi.org/10.5061/dryad.5241h/1 https://doi.org/10.1038/hdy.2015.37 2020-01-01T15:18:13Z Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an important component of disease control. The aim of this study was to explore the genetic architecture of resistance to PD, using survival data collected from two unrelated populations of Atlantic salmon; one challenged with SAV as fry in freshwater (POP 1) and one challenged with SAV as post-smolts in sea water (POP 2). Analyses of the binary survival data revealed a moderate-to-high heritability for host resistance to PD in both populations (fry POP 1 h2~0.5; post-smolt POP 2 h2~0.4). Subsets of both populations were genotyped for single nucleotide polymorphism markers, and six putative resistance quantitative trait loci (QTL) were identified. One of these QTL was mapped to the same location on chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-based analyses in POP 1, and genome-wide significance in a combined analysis in POP 2. This independently verified QTL explains a significant proportion of host genetic variation in resistance to PD in both populations, suggesting a common underlying mechanism for genetic resistance across lifecycle stages. Markers associated with this QTL are being incorporated into selective breeding programs to improve PD resistance. Article in Journal/Newspaper Atlantic salmon Salmo salar Dryad Digital Repository (Duke University) Sav’ ENVELOPE(156.400,156.400,68.817,68.817) |
institution |
Open Polar |
collection |
Dryad Digital Repository (Duke University) |
op_collection_id |
ftdryad |
language |
unknown |
topic |
Atlantic salmon Pancreas disease Salmonid alphavirus QTL mapping Genetic variation Disease resistance |
spellingShingle |
Atlantic salmon Pancreas disease Salmonid alphavirus QTL mapping Genetic variation Disease resistance Gonen, Serap Baranski, Matthew Thorland, Ingunn Norris, Ashie Grove, Harald Arnesen, Petter Bakke, Håvard Lien, Sigbjørn Bishop, Stephen C. Houston, Ross D. Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
topic_facet |
Atlantic salmon Pancreas disease Salmonid alphavirus QTL mapping Genetic variation Disease resistance |
description |
Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an important component of disease control. The aim of this study was to explore the genetic architecture of resistance to PD, using survival data collected from two unrelated populations of Atlantic salmon; one challenged with SAV as fry in freshwater (POP 1) and one challenged with SAV as post-smolts in sea water (POP 2). Analyses of the binary survival data revealed a moderate-to-high heritability for host resistance to PD in both populations (fry POP 1 h2~0.5; post-smolt POP 2 h2~0.4). Subsets of both populations were genotyped for single nucleotide polymorphism markers, and six putative resistance quantitative trait loci (QTL) were identified. One of these QTL was mapped to the same location on chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-based analyses in POP 1, and genome-wide significance in a combined analysis in POP 2. This independently verified QTL explains a significant proportion of host genetic variation in resistance to PD in both populations, suggesting a common underlying mechanism for genetic resistance across lifecycle stages. Markers associated with this QTL are being incorporated into selective breeding programs to improve PD resistance. |
format |
Article in Journal/Newspaper |
author |
Gonen, Serap Baranski, Matthew Thorland, Ingunn Norris, Ashie Grove, Harald Arnesen, Petter Bakke, Håvard Lien, Sigbjørn Bishop, Stephen C. Houston, Ross D. |
author_facet |
Gonen, Serap Baranski, Matthew Thorland, Ingunn Norris, Ashie Grove, Harald Arnesen, Petter Bakke, Håvard Lien, Sigbjørn Bishop, Stephen C. Houston, Ross D. |
author_sort |
Gonen, Serap |
title |
Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_short |
Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_full |
Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_fullStr |
Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_full_unstemmed |
Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_sort |
data from: mapping and validation of a major qtl affecting resistance to pancreas disease (salmonid alphavirus) in atlantic salmon (salmo salar) |
publishDate |
2015 |
url |
http://hdl.handle.net/10255/dryad.83922 https://doi.org/10.5061/dryad.5241h |
long_lat |
ENVELOPE(156.400,156.400,68.817,68.817) |
geographic |
Sav’ |
geographic_facet |
Sav’ |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
doi:10.5061/dryad.5241h/1 doi:10.1038/hdy.2015.37 PMID:25990876 doi:10.5061/dryad.5241h Gonen S, Baranski M, Thorland I, Norris A, Grove H, Arnesen P, Bakke H, Lien S, Bishop SC, Houston RD (2015) Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar). Heredity 115: 405–414. http://hdl.handle.net/10255/dryad.83922 |
op_doi |
https://doi.org/10.5061/dryad.5241h https://doi.org/10.5061/dryad.5241h/1 https://doi.org/10.1038/hdy.2015.37 |
_version_ |
1766360847518531584 |