Data from: Oxidative stress is a potential cost of breeding in male and female northern elephant seals.
1.The trade-off between current reproductive effort and survival is a key concept of life history theory. A variety of studies support the existence of this trade-off but the underlying physiological mechanisms are not well-understood. Oxidative stress has been proposed as a potential mechanism unde...
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ftdryad:oai:v1.datadryad.org:10255/dryad.68978 2023-05-15T16:05:39+02:00 Data from: Oxidative stress is a potential cost of breeding in male and female northern elephant seals. Sharick, Jeffrey T. Vazquez-Medina, Jose P. Ortiz, Rudy M. Crocker, Daniel E. 2014-09-09T18:25:31Z http://hdl.handle.net/10255/dryad.68978 https://doi.org/10.5061/dryad.q32td unknown doi:10.5061/dryad.q32td/1 doi:10.1111/1365-2435.12330 PMID:25983364 doi:10.5061/dryad.q32td Sharick JT, Vazquez-Medina JP, Ortiz RM, Crocker DE (2014) Oxidative stress is a potential cost of breeding in male and female northern elephant seals. Functional Ecology, 29(3): 367–376. http://hdl.handle.net/10255/dryad.68978 reproduction life-history theory pinnipeds fasting lipid peroxidation Article 2014 ftdryad https://doi.org/10.5061/dryad.q32td https://doi.org/10.5061/dryad.q32td/1 https://doi.org/10.1111/1365-2435.12330 2020-01-01T15:10:52Z 1.The trade-off between current reproductive effort and survival is a key concept of life history theory. A variety of studies support the existence of this trade-off but the underlying physiological mechanisms are not well-understood. Oxidative stress has been proposed as a potential mechanism underlying the observed inverse relationship between reproductive investment and lifespan. Prolonged fasting is associated with oxidative stress including increases in the production of reactive oxygen species, oxidative damage and inflammation. 2.Northern elephant seals (NES) undergo prolonged fasts while maintaining high metabolic rates during breeding. We investigated NES of both sexes to assess oxidative stress associated with extended breeding fasts. We measured changes in the plasma activity or concentrations of markers for oxidative stress in 30 adult male and 33 adult female northern elephant seals across their 1-3 month breeding fasts. Markers assessed included a pro-oxidant enzyme, several antioxidant enzymes, markers for oxidative damage to lipids, proteins and DNA, and markers for systemic inflammation. 3.Plasma xanthine oxidase (XO), a pro-oxidant enzyme that increases production of oxidative radicals, and several protective antioxidant enzymes increased over breeding in both sexes. Males showed increased oxidative damage to lipids and DNA and increased systemic inflammation, while oxidative damage to proteins declined across breeding. In contrast, females showed no oxidative damage to lipids or DNA or changes in inflammation, but showed increases in oxidative damage to proteins. XO activity, antioxidant enzymes, oxidative damage markers, and inflammatory markers were strongly correlated in males but these relationships were weaker or non-existent in females. 4.NES provide evidence for oxidative stress as a physiological cost of reproduction in a capital breeding mammal. Both sexes strongly up-regulated antioxidant defenses during breeding. Despite this response, and in contrast to similar duration non-breeding fasts in previous studies on conspecifics, there was evidence of oxidative damage to tissues. These data demonstrate the utility of using plasma markers to examine oxidative stress but also suggest the necessity of measuring a broad suite of plasma markers to assess systemic oxidative stress. Article in Journal/Newspaper Elephant Seals Dryad Digital Repository (Duke University) Nes ENVELOPE(7.634,7.634,62.795,62.795) Nes’ ENVELOPE(44.681,44.681,66.600,66.600) |
institution |
Open Polar |
collection |
Dryad Digital Repository (Duke University) |
op_collection_id |
ftdryad |
language |
unknown |
topic |
reproduction life-history theory pinnipeds fasting lipid peroxidation |
spellingShingle |
reproduction life-history theory pinnipeds fasting lipid peroxidation Sharick, Jeffrey T. Vazquez-Medina, Jose P. Ortiz, Rudy M. Crocker, Daniel E. Data from: Oxidative stress is a potential cost of breeding in male and female northern elephant seals. |
topic_facet |
reproduction life-history theory pinnipeds fasting lipid peroxidation |
description |
1.The trade-off between current reproductive effort and survival is a key concept of life history theory. A variety of studies support the existence of this trade-off but the underlying physiological mechanisms are not well-understood. Oxidative stress has been proposed as a potential mechanism underlying the observed inverse relationship between reproductive investment and lifespan. Prolonged fasting is associated with oxidative stress including increases in the production of reactive oxygen species, oxidative damage and inflammation. 2.Northern elephant seals (NES) undergo prolonged fasts while maintaining high metabolic rates during breeding. We investigated NES of both sexes to assess oxidative stress associated with extended breeding fasts. We measured changes in the plasma activity or concentrations of markers for oxidative stress in 30 adult male and 33 adult female northern elephant seals across their 1-3 month breeding fasts. Markers assessed included a pro-oxidant enzyme, several antioxidant enzymes, markers for oxidative damage to lipids, proteins and DNA, and markers for systemic inflammation. 3.Plasma xanthine oxidase (XO), a pro-oxidant enzyme that increases production of oxidative radicals, and several protective antioxidant enzymes increased over breeding in both sexes. Males showed increased oxidative damage to lipids and DNA and increased systemic inflammation, while oxidative damage to proteins declined across breeding. In contrast, females showed no oxidative damage to lipids or DNA or changes in inflammation, but showed increases in oxidative damage to proteins. XO activity, antioxidant enzymes, oxidative damage markers, and inflammatory markers were strongly correlated in males but these relationships were weaker or non-existent in females. 4.NES provide evidence for oxidative stress as a physiological cost of reproduction in a capital breeding mammal. Both sexes strongly up-regulated antioxidant defenses during breeding. Despite this response, and in contrast to similar duration non-breeding fasts in previous studies on conspecifics, there was evidence of oxidative damage to tissues. These data demonstrate the utility of using plasma markers to examine oxidative stress but also suggest the necessity of measuring a broad suite of plasma markers to assess systemic oxidative stress. |
format |
Article in Journal/Newspaper |
author |
Sharick, Jeffrey T. Vazquez-Medina, Jose P. Ortiz, Rudy M. Crocker, Daniel E. |
author_facet |
Sharick, Jeffrey T. Vazquez-Medina, Jose P. Ortiz, Rudy M. Crocker, Daniel E. |
author_sort |
Sharick, Jeffrey T. |
title |
Data from: Oxidative stress is a potential cost of breeding in male and female northern elephant seals. |
title_short |
Data from: Oxidative stress is a potential cost of breeding in male and female northern elephant seals. |
title_full |
Data from: Oxidative stress is a potential cost of breeding in male and female northern elephant seals. |
title_fullStr |
Data from: Oxidative stress is a potential cost of breeding in male and female northern elephant seals. |
title_full_unstemmed |
Data from: Oxidative stress is a potential cost of breeding in male and female northern elephant seals. |
title_sort |
data from: oxidative stress is a potential cost of breeding in male and female northern elephant seals. |
publishDate |
2014 |
url |
http://hdl.handle.net/10255/dryad.68978 https://doi.org/10.5061/dryad.q32td |
long_lat |
ENVELOPE(7.634,7.634,62.795,62.795) ENVELOPE(44.681,44.681,66.600,66.600) |
geographic |
Nes Nes’ |
geographic_facet |
Nes Nes’ |
genre |
Elephant Seals |
genre_facet |
Elephant Seals |
op_relation |
doi:10.5061/dryad.q32td/1 doi:10.1111/1365-2435.12330 PMID:25983364 doi:10.5061/dryad.q32td Sharick JT, Vazquez-Medina JP, Ortiz RM, Crocker DE (2014) Oxidative stress is a potential cost of breeding in male and female northern elephant seals. Functional Ecology, 29(3): 367–376. http://hdl.handle.net/10255/dryad.68978 |
op_doi |
https://doi.org/10.5061/dryad.q32td https://doi.org/10.5061/dryad.q32td/1 https://doi.org/10.1111/1365-2435.12330 |
_version_ |
1766401541721292800 |