Data from: Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals
On the basis of a general low polymorphism, several studies suggest that balancing selection in the class II major histocompatibility complex (MHC) is weaker in marine mammals as compared with terrestrial mammals. We investigated such differential selection among Cetacea, Artiodactyla, and Primates...
Main Authors: | , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
2013
|
Subjects: | |
Online Access: | http://hdl.handle.net/10255/dryad.42768 https://doi.org/10.5061/dryad.b33m7 |
id |
ftdryad:oai:v1.datadryad.org:10255/dryad.42768 |
---|---|
record_format |
openpolar |
spelling |
ftdryad:oai:v1.datadryad.org:10255/dryad.42768 2023-05-15T18:26:49+02:00 Data from: Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals Villanueva-Noriega, María José Baker, Charles Scott Medrano-González, Luis Global Holocene 2013-03-05T18:19:42Z http://hdl.handle.net/10255/dryad.42768 https://doi.org/10.5061/dryad.b33m7 unknown doi:10.5061/dryad.b33m7/1 doi:10.1007/s00251-012-0647-8 PMID:23064401 doi:10.5061/dryad.b33m7 Villanueva-Noriega MJ, Baker CS, Medrano-González L (2012) Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals. Immunogenetics 65(1): 47-61. http://hdl.handle.net/10255/dryad.42768 Major histocompatibility complex DQB Cytochrome b Nonsynonymous nucleotide substitution Transpecific polymorphism Marine mammals Article 2013 ftdryad https://doi.org/10.5061/dryad.b33m7 https://doi.org/10.5061/dryad.b33m7/1 https://doi.org/10.1007/s00251-012-0647-8 2020-01-01T14:58:04Z On the basis of a general low polymorphism, several studies suggest that balancing selection in the class II major histocompatibility complex (MHC) is weaker in marine mammals as compared with terrestrial mammals. We investigated such differential selection among Cetacea, Artiodactyla, and Primates at exon 2 of MHC-DQB gene by contrasting indicators of molecular evolution such as occurrence of transpecific polymorphisms, patterns of phylogenetic branch lengths by codon position, rates of nonsynonymous and synonymous substitutions as well as accumulation of variable sites on the sampling of alleles. These indicators were compared between the DQB and the mitochondrial cytochrome b gene (cytb) as a reference of neutral expectations and differences between molecular clocks resulting from life history and historical demography. All indicators showed that the influence of balancing selection on the DQB is more variable and overall weaker for cetaceans. In our sampling, ziphiids, the sperm whale, monodontids and the finless porpoise formed a group with lower DQB polymorphism, while mysticetes exhibited a higher DQB variation similar to that of terrestrial mammals as well as higher occurrence of transpecific polymorphisms. Different dolphins appeared in the two groups. Larger variation of selection on the cetacean DQB could be related to greater stochasticity in their historical demography and thus, to a greater complexity of the general ecology and disease processes of these animals. Article in Journal/Newspaper Sperm whale Dryad Digital Repository (Duke University) |
institution |
Open Polar |
collection |
Dryad Digital Repository (Duke University) |
op_collection_id |
ftdryad |
language |
unknown |
topic |
Major histocompatibility complex DQB Cytochrome b Nonsynonymous nucleotide substitution Transpecific polymorphism Marine mammals |
spellingShingle |
Major histocompatibility complex DQB Cytochrome b Nonsynonymous nucleotide substitution Transpecific polymorphism Marine mammals Villanueva-Noriega, María José Baker, Charles Scott Medrano-González, Luis Data from: Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals |
topic_facet |
Major histocompatibility complex DQB Cytochrome b Nonsynonymous nucleotide substitution Transpecific polymorphism Marine mammals |
description |
On the basis of a general low polymorphism, several studies suggest that balancing selection in the class II major histocompatibility complex (MHC) is weaker in marine mammals as compared with terrestrial mammals. We investigated such differential selection among Cetacea, Artiodactyla, and Primates at exon 2 of MHC-DQB gene by contrasting indicators of molecular evolution such as occurrence of transpecific polymorphisms, patterns of phylogenetic branch lengths by codon position, rates of nonsynonymous and synonymous substitutions as well as accumulation of variable sites on the sampling of alleles. These indicators were compared between the DQB and the mitochondrial cytochrome b gene (cytb) as a reference of neutral expectations and differences between molecular clocks resulting from life history and historical demography. All indicators showed that the influence of balancing selection on the DQB is more variable and overall weaker for cetaceans. In our sampling, ziphiids, the sperm whale, monodontids and the finless porpoise formed a group with lower DQB polymorphism, while mysticetes exhibited a higher DQB variation similar to that of terrestrial mammals as well as higher occurrence of transpecific polymorphisms. Different dolphins appeared in the two groups. Larger variation of selection on the cetacean DQB could be related to greater stochasticity in their historical demography and thus, to a greater complexity of the general ecology and disease processes of these animals. |
format |
Article in Journal/Newspaper |
author |
Villanueva-Noriega, María José Baker, Charles Scott Medrano-González, Luis |
author_facet |
Villanueva-Noriega, María José Baker, Charles Scott Medrano-González, Luis |
author_sort |
Villanueva-Noriega, María José |
title |
Data from: Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals |
title_short |
Data from: Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals |
title_full |
Data from: Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals |
title_fullStr |
Data from: Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals |
title_full_unstemmed |
Data from: Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals |
title_sort |
data from: evolution of the mhc-dqb exon 2 in marine and terrestrial mammals |
publishDate |
2013 |
url |
http://hdl.handle.net/10255/dryad.42768 https://doi.org/10.5061/dryad.b33m7 |
op_coverage |
Global Holocene |
genre |
Sperm whale |
genre_facet |
Sperm whale |
op_relation |
doi:10.5061/dryad.b33m7/1 doi:10.1007/s00251-012-0647-8 PMID:23064401 doi:10.5061/dryad.b33m7 Villanueva-Noriega MJ, Baker CS, Medrano-González L (2012) Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals. Immunogenetics 65(1): 47-61. http://hdl.handle.net/10255/dryad.42768 |
op_doi |
https://doi.org/10.5061/dryad.b33m7 https://doi.org/10.5061/dryad.b33m7/1 https://doi.org/10.1007/s00251-012-0647-8 |
_version_ |
1766208789751529472 |