Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals
Numerous studies have reported correlations between the heterozygosity of genetic markers and fitness. These heterozygosity fitness correlations (HFCs) play a central role in evolutionary and conservation biology, yet their mechanistic basis remains open to debate. For example, fitness associations...
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ftdryad:oai:v1.datadryad.org:10255/dryad.216107 2023-05-15T14:02:40+02:00 Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals Litzke, Vivienne Ottensmann, Meinolf Forcada, Jaume Heitzmann, Louise Hoffman, Joseph Ivan Bird Island South Georgia 2019-07-15T20:34:22Z http://hdl.handle.net/10255/dryad.216107 https://doi.org/10.5061/dryad.vk4br80 unknown doi:10.5061/dryad.vk4br80/3 doi:10.5061/dryad.vk4br80/4 doi:10.5061/dryad.vk4br80/5 doi:10.5061/dryad.vk4br80/6 doi:10.5061/dryad.vk4br80/7 doi:10.5061/dryad.vk4br80/2 doi:10.5061/dryad.vk4br80/8 doi:10.5061/dryad.vk4br80/9 doi:10.5061/dryad.vk4br80/10 doi:10.5061/dryad.vk4br80/11 doi:10.5061/dryad.vk4br80/12 doi:10.5061/dryad.vk4br80/13 doi:10.5061/dryad.vk4br80/14 doi:10.5061/dryad.vk4br80/15 doi:10.5061/dryad.vk4br80/1 doi:10.1002/ece3.5317 doi:10.5061/dryad.vk4br80 Litzke V, Ottensmann M, Forcada J, Heitzmann L, Hoffman JI (2019) Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals. Ecology and Evolution 9(14): 7985-7996. http://hdl.handle.net/10255/dryad.216107 Antarctic fur seal heterozygosity fitness correlation (HFC) bacterial infection inbreeding pinniped Article 2019 ftdryad https://doi.org/10.5061/dryad.vk4br80 https://doi.org/10.5061/dryad.vk4br80/3 https://doi.org/10.5061/dryad.vk4br80/4 https://doi.org/10.5061/dryad.vk4br80/5 https://doi.org/10.5061/dryad.vk4br80/6 https://doi.org/10.5061/dryad.vk4br80/7 https 2020-01-01T16:28:22Z Numerous studies have reported correlations between the heterozygosity of genetic markers and fitness. These heterozygosity fitness correlations (HFCs) play a central role in evolutionary and conservation biology, yet their mechanistic basis remains open to debate. For example, fitness associations have been widely reported at both neutral and functional loci, yet few studies have directly compared the two, making it difficult to gauge the relative contributions of genome-wide inbreeding and functional genetic variation to fitness. Here, we compared the effects of neutral and immune gene heterozygosity on death from bacterial infection in Antarctic fur seal (Arctocephalus gazella) pups. We specifically developed a panel of 13 microsatellites from expressed immune genes and genotyped these together with 48 neutral loci in 234 individuals, comprising 39 pups that were classified at necropsy as having most likely died of bacterial infection together with a five times larger matched sample of healthy surviving pups. Identity disequilibrium quantified from the neutral markers was positive and significant, indicative of variance in inbreeding within the study population. However, multilocus heterozygosity did not differ significantly between healthy and infected pups at either class of marker, and little evidence was found for fitness associations at individual loci. These results support a previous study of Antarctic fur seals that found no effects of heterozygosity at nine neutral microsatellites on neonatal survival, and thereby help to refine our understanding of how HFCs vary across the life cycle. Given that non-significant HFCs are underreported in the literature, we also hope that our study will contribute towards a more balanced understanding of the wider importance of this phenomenon. Article in Journal/Newspaper Antarc* Antarctic Antarctic Fur Seal Antarctic Fur Seals Arctocephalus gazella Bird Island Dryad Digital Repository (Duke University) Antarctic Bird Island ENVELOPE(-38.060,-38.060,-54.004,-54.004) |
institution |
Open Polar |
collection |
Dryad Digital Repository (Duke University) |
op_collection_id |
ftdryad |
language |
unknown |
topic |
Antarctic fur seal heterozygosity fitness correlation (HFC) bacterial infection inbreeding pinniped |
spellingShingle |
Antarctic fur seal heterozygosity fitness correlation (HFC) bacterial infection inbreeding pinniped Litzke, Vivienne Ottensmann, Meinolf Forcada, Jaume Heitzmann, Louise Hoffman, Joseph Ivan Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals |
topic_facet |
Antarctic fur seal heterozygosity fitness correlation (HFC) bacterial infection inbreeding pinniped |
description |
Numerous studies have reported correlations between the heterozygosity of genetic markers and fitness. These heterozygosity fitness correlations (HFCs) play a central role in evolutionary and conservation biology, yet their mechanistic basis remains open to debate. For example, fitness associations have been widely reported at both neutral and functional loci, yet few studies have directly compared the two, making it difficult to gauge the relative contributions of genome-wide inbreeding and functional genetic variation to fitness. Here, we compared the effects of neutral and immune gene heterozygosity on death from bacterial infection in Antarctic fur seal (Arctocephalus gazella) pups. We specifically developed a panel of 13 microsatellites from expressed immune genes and genotyped these together with 48 neutral loci in 234 individuals, comprising 39 pups that were classified at necropsy as having most likely died of bacterial infection together with a five times larger matched sample of healthy surviving pups. Identity disequilibrium quantified from the neutral markers was positive and significant, indicative of variance in inbreeding within the study population. However, multilocus heterozygosity did not differ significantly between healthy and infected pups at either class of marker, and little evidence was found for fitness associations at individual loci. These results support a previous study of Antarctic fur seals that found no effects of heterozygosity at nine neutral microsatellites on neonatal survival, and thereby help to refine our understanding of how HFCs vary across the life cycle. Given that non-significant HFCs are underreported in the literature, we also hope that our study will contribute towards a more balanced understanding of the wider importance of this phenomenon. |
format |
Article in Journal/Newspaper |
author |
Litzke, Vivienne Ottensmann, Meinolf Forcada, Jaume Heitzmann, Louise Hoffman, Joseph Ivan |
author_facet |
Litzke, Vivienne Ottensmann, Meinolf Forcada, Jaume Heitzmann, Louise Hoffman, Joseph Ivan |
author_sort |
Litzke, Vivienne |
title |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals |
title_short |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals |
title_full |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals |
title_fullStr |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals |
title_full_unstemmed |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals |
title_sort |
data from: heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in antarctic fur seals |
publishDate |
2019 |
url |
http://hdl.handle.net/10255/dryad.216107 https://doi.org/10.5061/dryad.vk4br80 |
op_coverage |
Bird Island South Georgia |
long_lat |
ENVELOPE(-38.060,-38.060,-54.004,-54.004) |
geographic |
Antarctic Bird Island |
geographic_facet |
Antarctic Bird Island |
genre |
Antarc* Antarctic Antarctic Fur Seal Antarctic Fur Seals Arctocephalus gazella Bird Island |
genre_facet |
Antarc* Antarctic Antarctic Fur Seal Antarctic Fur Seals Arctocephalus gazella Bird Island |
op_relation |
doi:10.5061/dryad.vk4br80/3 doi:10.5061/dryad.vk4br80/4 doi:10.5061/dryad.vk4br80/5 doi:10.5061/dryad.vk4br80/6 doi:10.5061/dryad.vk4br80/7 doi:10.5061/dryad.vk4br80/2 doi:10.5061/dryad.vk4br80/8 doi:10.5061/dryad.vk4br80/9 doi:10.5061/dryad.vk4br80/10 doi:10.5061/dryad.vk4br80/11 doi:10.5061/dryad.vk4br80/12 doi:10.5061/dryad.vk4br80/13 doi:10.5061/dryad.vk4br80/14 doi:10.5061/dryad.vk4br80/15 doi:10.5061/dryad.vk4br80/1 doi:10.1002/ece3.5317 doi:10.5061/dryad.vk4br80 Litzke V, Ottensmann M, Forcada J, Heitzmann L, Hoffman JI (2019) Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals. Ecology and Evolution 9(14): 7985-7996. http://hdl.handle.net/10255/dryad.216107 |
op_doi |
https://doi.org/10.5061/dryad.vk4br80 https://doi.org/10.5061/dryad.vk4br80/3 https://doi.org/10.5061/dryad.vk4br80/4 https://doi.org/10.5061/dryad.vk4br80/5 https://doi.org/10.5061/dryad.vk4br80/6 https://doi.org/10.5061/dryad.vk4br80/7 https |
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