Data from: Heritability of body size in the polar bears of Western Hudson Bay
Among polar bears (Ursus maritimus), fitness is dependent on body size through males' abilities to win mates, females' abilities to provide for their young, and all bears' abilities to survive increasingly longer fasting periods caused by climate change. In the Western Hudson Bay subp...
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ftdryad:oai:v1.datadryad.org:10255/dryad.164280 2023-05-15T15:55:08+02:00 Data from: Heritability of body size in the polar bears of Western Hudson Bay Malenfant, René M. Davis, Corey S. Richardson, Evan S. Lunn, Nicholas J. Coltman, David W. Hudson Bay Holocene 2018-03-30T16:51:21Z http://hdl.handle.net/10255/dryad.164280 https://doi.org/10.5061/dryad.23d8v unknown doi:10.5061/dryad.23d8v/2 doi:10.5061/dryad.23d8v/3 doi:10.5061/dryad.23d8v/4 doi:10.5061/dryad.23d8v/5 doi:10.5061/dryad.23d8v/7 doi:10.1111/1755-0998.12889 doi:10.5061/dryad.23d8v Malenfant RM, Davis CS, Richardson ES, Lunn NJ, Coltman DW (2018) Heritability of body size in the polar bears of Western Hudson Bay. Molecular Ecology Resources 18(4): 854-866. http://hdl.handle.net/10255/dryad.164280 Quantitative Genetics Mammals animal model GWAS single-nucleotide polymorphism Infinium BeadChip Article 2018 ftdryad https://doi.org/10.5061/dryad.23d8v https://doi.org/10.5061/dryad.23d8v/2 https://doi.org/10.5061/dryad.23d8v/3 https://doi.org/10.5061/dryad.23d8v/4 https://doi.org/10.5061/dryad.23d8v/5 https://doi.org/10.5061/dryad.23d8v/7 https://doi.org/1 2020-01-01T16:00:53Z Among polar bears (Ursus maritimus), fitness is dependent on body size through males' abilities to win mates, females' abilities to provide for their young, and all bears' abilities to survive increasingly longer fasting periods caused by climate change. In the Western Hudson Bay subpopulation (near Churchill, Manitoba, Canada), polar bears have declined in body size and condition, but nothing is known about the genetic underpinnings of body size variation, which may be subject to natural selection. Here, we combine a 4449-individual pedigree and an array of 5433 single-nucleotide polymorphisms (SNPs) to provide the first quantitative genetics study of polar bears. We used animal models to estimate heritability (h2) among polar bears handled between 1966 and 2011, obtaining h2 estimates of 0.34-0.48 for strictly skeletal traits and 0.18 for axillary girth (which is also dependent on fatness). We genotyped 859 individuals with the SNP array to test for marker-trait association and combined p-values over genetic pathways using gene-set analysis. Variation in all traits appeared to be polygenic, but we detected one region of moderately large effect size in body length near a putative noncoding RNA in an unannotated region of the genome. Gene-set analysis suggested that variation in body length was associated with genes in the regulatory cascade of cyclin expression, which has previously been associated with body size in mice. A greater understanding of the genetic architecture of body size variation will be valuable in understanding the potential for adaptation in polar bear populations challenged by climate change. Article in Journal/Newspaper Churchill Hudson Bay polar bear Ursus maritimus Dryad Digital Repository (Duke University) Canada Hudson Hudson Bay |
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Open Polar |
collection |
Dryad Digital Repository (Duke University) |
op_collection_id |
ftdryad |
language |
unknown |
topic |
Quantitative Genetics Mammals animal model GWAS single-nucleotide polymorphism Infinium BeadChip |
spellingShingle |
Quantitative Genetics Mammals animal model GWAS single-nucleotide polymorphism Infinium BeadChip Malenfant, René M. Davis, Corey S. Richardson, Evan S. Lunn, Nicholas J. Coltman, David W. Data from: Heritability of body size in the polar bears of Western Hudson Bay |
topic_facet |
Quantitative Genetics Mammals animal model GWAS single-nucleotide polymorphism Infinium BeadChip |
description |
Among polar bears (Ursus maritimus), fitness is dependent on body size through males' abilities to win mates, females' abilities to provide for their young, and all bears' abilities to survive increasingly longer fasting periods caused by climate change. In the Western Hudson Bay subpopulation (near Churchill, Manitoba, Canada), polar bears have declined in body size and condition, but nothing is known about the genetic underpinnings of body size variation, which may be subject to natural selection. Here, we combine a 4449-individual pedigree and an array of 5433 single-nucleotide polymorphisms (SNPs) to provide the first quantitative genetics study of polar bears. We used animal models to estimate heritability (h2) among polar bears handled between 1966 and 2011, obtaining h2 estimates of 0.34-0.48 for strictly skeletal traits and 0.18 for axillary girth (which is also dependent on fatness). We genotyped 859 individuals with the SNP array to test for marker-trait association and combined p-values over genetic pathways using gene-set analysis. Variation in all traits appeared to be polygenic, but we detected one region of moderately large effect size in body length near a putative noncoding RNA in an unannotated region of the genome. Gene-set analysis suggested that variation in body length was associated with genes in the regulatory cascade of cyclin expression, which has previously been associated with body size in mice. A greater understanding of the genetic architecture of body size variation will be valuable in understanding the potential for adaptation in polar bear populations challenged by climate change. |
format |
Article in Journal/Newspaper |
author |
Malenfant, René M. Davis, Corey S. Richardson, Evan S. Lunn, Nicholas J. Coltman, David W. |
author_facet |
Malenfant, René M. Davis, Corey S. Richardson, Evan S. Lunn, Nicholas J. Coltman, David W. |
author_sort |
Malenfant, René M. |
title |
Data from: Heritability of body size in the polar bears of Western Hudson Bay |
title_short |
Data from: Heritability of body size in the polar bears of Western Hudson Bay |
title_full |
Data from: Heritability of body size in the polar bears of Western Hudson Bay |
title_fullStr |
Data from: Heritability of body size in the polar bears of Western Hudson Bay |
title_full_unstemmed |
Data from: Heritability of body size in the polar bears of Western Hudson Bay |
title_sort |
data from: heritability of body size in the polar bears of western hudson bay |
publishDate |
2018 |
url |
http://hdl.handle.net/10255/dryad.164280 https://doi.org/10.5061/dryad.23d8v |
op_coverage |
Hudson Bay Holocene |
geographic |
Canada Hudson Hudson Bay |
geographic_facet |
Canada Hudson Hudson Bay |
genre |
Churchill Hudson Bay polar bear Ursus maritimus |
genre_facet |
Churchill Hudson Bay polar bear Ursus maritimus |
op_relation |
doi:10.5061/dryad.23d8v/2 doi:10.5061/dryad.23d8v/3 doi:10.5061/dryad.23d8v/4 doi:10.5061/dryad.23d8v/5 doi:10.5061/dryad.23d8v/7 doi:10.1111/1755-0998.12889 doi:10.5061/dryad.23d8v Malenfant RM, Davis CS, Richardson ES, Lunn NJ, Coltman DW (2018) Heritability of body size in the polar bears of Western Hudson Bay. Molecular Ecology Resources 18(4): 854-866. http://hdl.handle.net/10255/dryad.164280 |
op_doi |
https://doi.org/10.5061/dryad.23d8v https://doi.org/10.5061/dryad.23d8v/2 https://doi.org/10.5061/dryad.23d8v/3 https://doi.org/10.5061/dryad.23d8v/4 https://doi.org/10.5061/dryad.23d8v/5 https://doi.org/10.5061/dryad.23d8v/7 https://doi.org/1 |
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1766390468041506816 |