Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas
The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas....
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ftdryad:oai:v1.datadryad.org:10255/dryad.132766 2023-05-15T15:57:51+02:00 Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng 2017-01-12T21:21:29Z http://hdl.handle.net/10255/dryad.132766 https://doi.org/10.5061/dryad.7d6c5 unknown doi:10.5061/dryad.7d6c5/1 doi:10.1098/rsob.160289 doi:10.5061/dryad.7d6c5 Liu Z, Zhou Z, Jiang Q, Wang L, Yi Q, Qiu L, Song L (2017) The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas. Open Biology 7(1): 160289. 2046-2441 http://hdl.handle.net/10255/dryad.132766 Neuroendocrine immunomodulatory axis Circulating haemocyte Membrane receptor Immune regulation Article 2017 ftdryad https://doi.org/10.5061/dryad.7d6c5 https://doi.org/10.5061/dryad.7d6c5/1 https://doi.org/10.1098/rsob.160289 2020-01-01T15:43:54Z The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the ‘nervous-haemocyte’ NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Dryad Digital Repository (Duke University) Pacific |
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Open Polar |
collection |
Dryad Digital Repository (Duke University) |
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ftdryad |
language |
unknown |
topic |
Neuroendocrine immunomodulatory axis Circulating haemocyte Membrane receptor Immune regulation |
spellingShingle |
Neuroendocrine immunomodulatory axis Circulating haemocyte Membrane receptor Immune regulation Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
topic_facet |
Neuroendocrine immunomodulatory axis Circulating haemocyte Membrane receptor Immune regulation |
description |
The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the ‘nervous-haemocyte’ NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. |
format |
Article in Journal/Newspaper |
author |
Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng |
author_facet |
Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng |
author_sort |
Liu, Zhaoqun |
title |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_short |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_full |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_fullStr |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_full_unstemmed |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_sort |
data from: the neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster crassostrea gigas |
publishDate |
2017 |
url |
http://hdl.handle.net/10255/dryad.132766 https://doi.org/10.5061/dryad.7d6c5 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
doi:10.5061/dryad.7d6c5/1 doi:10.1098/rsob.160289 doi:10.5061/dryad.7d6c5 Liu Z, Zhou Z, Jiang Q, Wang L, Yi Q, Qiu L, Song L (2017) The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas. Open Biology 7(1): 160289. 2046-2441 http://hdl.handle.net/10255/dryad.132766 |
op_doi |
https://doi.org/10.5061/dryad.7d6c5 https://doi.org/10.5061/dryad.7d6c5/1 https://doi.org/10.1098/rsob.160289 |
_version_ |
1766393566571003904 |