Data from: Evolution of the immune system influences speciation rates in teleost fishes
Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic and phenotypic variation, including diverse immune defense strategies. The genomic basis of a particularly aberrant strategy is exemplified by Atlantic cod, in which a loss of major histocompatibility comp...
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ftdryad:oai:v1.datadryad.org:10255/dryad.120269 2023-05-15T15:27:29+02:00 Data from: Evolution of the immune system influences speciation rates in teleost fishes Malmstrøm, Martin Matschiner, Michael Tørresen, Ole K. Star, Bastiaan Snipen, Lars G. Hansen, Thomas F. Baalsrud, Helle T. Nederbragt, Alexander J. Hanel, Reinhold Salzburger, Walter Stenseth, Nils C. Jakobsen, Kjetill S. Jentoft, Sissel Global Jurassic Cretaceous Cenozoic 2016-08-22T22:15:26Z http://hdl.handle.net/10255/dryad.120269 https://doi.org/10.5061/dryad.326r8 unknown doi:10.5061/dryad.326r8/1 doi:10.5061/dryad.326r8/2 doi:10.5061/dryad.326r8/3 doi:10.5061/dryad.326r8/4 doi:10.5061/dryad.326r8/5 doi:10.5061/dryad.326r8/6 doi:10.5061/dryad.326r8/7 doi:10.5061/dryad.326r8/8 doi:10.5061/dryad.326r8/9 doi:10.5061/dryad.326r8/10 doi:10.5061/dryad.326r8/11 doi:10.5061/dryad.326r8/12 doi:10.5061/dryad.326r8/13 doi:10.5061/dryad.326r8/14 doi:10.5061/dryad.326r8/15 doi:10.5061/dryad.326r8/16 doi:10.5061/dryad.326r8/17 doi:10.5061/dryad.326r8/18 doi:10.5061/dryad.326r8/19 doi:10.5061/dryad.326r8/20 doi:10.5061/dryad.326r8/21 doi:10.5061/dryad.326r8/22 doi:10.5061/dryad.326r8/23 doi:10.5061/dryad.326r8/24 doi:10.5061/dryad.326r8/25 doi:10.5061/dryad.326r8/26 doi:10.5061/dryad.326r8/27 doi:10.5061/dryad.326r8/28 doi:10.5061/dryad.326r8/29 doi:10.5061/dryad.326r8/30 doi:10.5061/dryad.326r8/31 doi:10.5061/dryad.326r8/32 doi:10.5061/dryad.326r8/33 doi:10.5061/dryad.326r8/34 doi:10.5061/dryad.326r8/35 doi:10.5061/dryad.326r8/36 doi:10.5061/dryad.326r8/37 doi:10.5061/dryad.326r8/38 doi:10.5061/dryad.326r8/39 doi:10.5061/dryad.326r8/40 doi:10.5061/dryad.326r8/41 doi:10.5061/dryad.326r8/42 doi:10.5061/dryad.326r8/43 doi:10.5061/dryad.326r8/44 doi:10.5061/dryad.326r8/45 doi:10.5061/dryad.326r8/46 doi:10.5061/dryad.326r8/47 doi:10.5061/dryad.326r8/48 doi:10.5061/dryad.326r8/49 doi:10.5061/dryad.326r8/50 Article 2016 ftdryad https://doi.org/10.5061/dryad.326r8 https://doi.org/10.5061/dryad.326r8/1 https://doi.org/10.5061/dryad.326r8/2 https://doi.org/10.5061/dryad.326r8/3 https://doi.org/10.5061/dryad.326r8/4 https://doi.org/10.5061/dryad.326r8/5 https://doi.org/1 2020-01-01T15:37:11Z Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic and phenotypic variation, including diverse immune defense strategies. The genomic basis of a particularly aberrant strategy is exemplified by Atlantic cod, in which a loss of major histocompatibility complex (MHC) II functionality coincides with a marked expansion of MHC I genes. Through low-coverage genome sequencing (9–39×), assembly and comparative analyses for 66 teleost species, we show here that MHC II is missing in the entire Gadiformes lineage and thus was lost once in their common ancestor. In contrast, we find that MHC I gene expansions have occurred multiple times, both inside and outside this clade. Moreover, we identify an association between high MHC I copy number and elevated speciation rates using trait-dependent diversification models. Our results extend current understanding of the plasticity of the adaptive immune system and suggest an important role for immune-related genes in animal diversification. Article in Journal/Newspaper atlantic cod Dryad Digital Repository (Duke University) |
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Open Polar |
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Dryad Digital Repository (Duke University) |
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ftdryad |
language |
unknown |
description |
Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic and phenotypic variation, including diverse immune defense strategies. The genomic basis of a particularly aberrant strategy is exemplified by Atlantic cod, in which a loss of major histocompatibility complex (MHC) II functionality coincides with a marked expansion of MHC I genes. Through low-coverage genome sequencing (9–39×), assembly and comparative analyses for 66 teleost species, we show here that MHC II is missing in the entire Gadiformes lineage and thus was lost once in their common ancestor. In contrast, we find that MHC I gene expansions have occurred multiple times, both inside and outside this clade. Moreover, we identify an association between high MHC I copy number and elevated speciation rates using trait-dependent diversification models. Our results extend current understanding of the plasticity of the adaptive immune system and suggest an important role for immune-related genes in animal diversification. |
format |
Article in Journal/Newspaper |
author |
Malmstrøm, Martin Matschiner, Michael Tørresen, Ole K. Star, Bastiaan Snipen, Lars G. Hansen, Thomas F. Baalsrud, Helle T. Nederbragt, Alexander J. Hanel, Reinhold Salzburger, Walter Stenseth, Nils C. Jakobsen, Kjetill S. Jentoft, Sissel |
spellingShingle |
Malmstrøm, Martin Matschiner, Michael Tørresen, Ole K. Star, Bastiaan Snipen, Lars G. Hansen, Thomas F. Baalsrud, Helle T. Nederbragt, Alexander J. Hanel, Reinhold Salzburger, Walter Stenseth, Nils C. Jakobsen, Kjetill S. Jentoft, Sissel Data from: Evolution of the immune system influences speciation rates in teleost fishes |
author_facet |
Malmstrøm, Martin Matschiner, Michael Tørresen, Ole K. Star, Bastiaan Snipen, Lars G. Hansen, Thomas F. Baalsrud, Helle T. Nederbragt, Alexander J. Hanel, Reinhold Salzburger, Walter Stenseth, Nils C. Jakobsen, Kjetill S. Jentoft, Sissel |
author_sort |
Malmstrøm, Martin |
title |
Data from: Evolution of the immune system influences speciation rates in teleost fishes |
title_short |
Data from: Evolution of the immune system influences speciation rates in teleost fishes |
title_full |
Data from: Evolution of the immune system influences speciation rates in teleost fishes |
title_fullStr |
Data from: Evolution of the immune system influences speciation rates in teleost fishes |
title_full_unstemmed |
Data from: Evolution of the immune system influences speciation rates in teleost fishes |
title_sort |
data from: evolution of the immune system influences speciation rates in teleost fishes |
publishDate |
2016 |
url |
http://hdl.handle.net/10255/dryad.120269 https://doi.org/10.5061/dryad.326r8 |
op_coverage |
Global Jurassic Cretaceous Cenozoic |
genre |
atlantic cod |
genre_facet |
atlantic cod |
op_relation |
doi:10.5061/dryad.326r8/1 doi:10.5061/dryad.326r8/2 doi:10.5061/dryad.326r8/3 doi:10.5061/dryad.326r8/4 doi:10.5061/dryad.326r8/5 doi:10.5061/dryad.326r8/6 doi:10.5061/dryad.326r8/7 doi:10.5061/dryad.326r8/8 doi:10.5061/dryad.326r8/9 doi:10.5061/dryad.326r8/10 doi:10.5061/dryad.326r8/11 doi:10.5061/dryad.326r8/12 doi:10.5061/dryad.326r8/13 doi:10.5061/dryad.326r8/14 doi:10.5061/dryad.326r8/15 doi:10.5061/dryad.326r8/16 doi:10.5061/dryad.326r8/17 doi:10.5061/dryad.326r8/18 doi:10.5061/dryad.326r8/19 doi:10.5061/dryad.326r8/20 doi:10.5061/dryad.326r8/21 doi:10.5061/dryad.326r8/22 doi:10.5061/dryad.326r8/23 doi:10.5061/dryad.326r8/24 doi:10.5061/dryad.326r8/25 doi:10.5061/dryad.326r8/26 doi:10.5061/dryad.326r8/27 doi:10.5061/dryad.326r8/28 doi:10.5061/dryad.326r8/29 doi:10.5061/dryad.326r8/30 doi:10.5061/dryad.326r8/31 doi:10.5061/dryad.326r8/32 doi:10.5061/dryad.326r8/33 doi:10.5061/dryad.326r8/34 doi:10.5061/dryad.326r8/35 doi:10.5061/dryad.326r8/36 doi:10.5061/dryad.326r8/37 doi:10.5061/dryad.326r8/38 doi:10.5061/dryad.326r8/39 doi:10.5061/dryad.326r8/40 doi:10.5061/dryad.326r8/41 doi:10.5061/dryad.326r8/42 doi:10.5061/dryad.326r8/43 doi:10.5061/dryad.326r8/44 doi:10.5061/dryad.326r8/45 doi:10.5061/dryad.326r8/46 doi:10.5061/dryad.326r8/47 doi:10.5061/dryad.326r8/48 doi:10.5061/dryad.326r8/49 doi:10.5061/dryad.326r8/50 |
op_doi |
https://doi.org/10.5061/dryad.326r8 https://doi.org/10.5061/dryad.326r8/1 https://doi.org/10.5061/dryad.326r8/2 https://doi.org/10.5061/dryad.326r8/3 https://doi.org/10.5061/dryad.326r8/4 https://doi.org/10.5061/dryad.326r8/5 https://doi.org/1 |
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