Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line
Nezar H Khdary,1 Abdulaziz A Alangari,2 Khadijah M Katubi,3 Mohammad Alanazi,4 Ahmed Alhassan,1 Sami D Alzahrani,1 Zahid Khan,4 Ibrahim O Alanazi1 1Institute of Materials Science, King Abdulaziz City for Science and Technology, Riyadh, Kingdom of Saudi Arabia; 2College of Medicine, King Saud Univers...
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ftdovepress:oai:dovepress.com/81300 2023-05-15T18:13:14+02:00 Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line Khdary,Nezar H Alangari,Abdulaziz A Katubi,Khadijah M Alanazi,Mohammad Alhassan,Ahmed Alzahrani,Sami D Khan,Zahid Alanazi,Ibrahim O 2023-01-27 text/html https://www.dovepress.com/synthesis-of-gingerol-metals-complex-and-in-vitro-cytotoxic-activity-o-peer-reviewed-fulltext-article-CMAR en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/CMAR.S391546 https://www.dovepress.com/synthesis-of-gingerol-metals-complex-and-in-vitro-cytotoxic-activity-o-peer-reviewed-fulltext-article-CMAR info:eu-repo/semantics/openAccess Cancer Management and Research Original Research info:eu-repo/semantics/article 2023 ftdovepress https://doi.org/10.2147/CMAR.S391546 2023-01-29T18:31:08Z Nezar H Khdary,1 Abdulaziz A Alangari,2 Khadijah M Katubi,3 Mohammad Alanazi,4 Ahmed Alhassan,1 Sami D Alzahrani,1 Zahid Khan,4 Ibrahim O Alanazi1 1Institute of Materials Science, King Abdulaziz City for Science and Technology, Riyadh, Kingdom of Saudi Arabia; 2College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; 4Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi ArabiaCorrespondence: Nezar H Khdary, Institute of Materials Science, King Abdulaziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia, Tel +966-114814236, Email nkhdary@kacst.edu.sa Ibrahim O Alanazi, Aging institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia, Tel +966114813289, Email ialenazi@kacst.edu.saIntroduction: Herbs are excellent sources of medicinal substances, and their curative abilities have been recognized to treat many ailments and are used for example as antioxidants, analgesics, anti-inflammatories, antipyretics, and many other medicinal uses. The properties of natural compounds and their health effects have been studied extensively, especially those that originate from plant sources such as ginger. The ginger plant contains many chemical compounds, such as 6-gingerol, which is characterized by containing active groups such as carbonyl and hydroxide, which can be attached to metal molecules. This is what was done in this study, where the formation of complexes with a group of metals was studied and their effect on cancer cells was investigated. These complexes will open new horizons for further study of medicinal uses.Methods: The synthesis of gingerol-metal complexes was carried out by conjugating gingerol molecules with Ag, Au, Cd, Co, Cu, Ni, and Zn metal ions. The extracted gingerol was transferred to culture tubes and deionized water-DMSO were added followed by sonication. ... Article in Journal/Newspaper sami sami Dove Medical Press Cancer Management and Research Volume 15 87 98 |
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Cancer Management and Research Khdary,Nezar H Alangari,Abdulaziz A Katubi,Khadijah M Alanazi,Mohammad Alhassan,Ahmed Alzahrani,Sami D Khan,Zahid Alanazi,Ibrahim O Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line |
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Cancer Management and Research |
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Nezar H Khdary,1 Abdulaziz A Alangari,2 Khadijah M Katubi,3 Mohammad Alanazi,4 Ahmed Alhassan,1 Sami D Alzahrani,1 Zahid Khan,4 Ibrahim O Alanazi1 1Institute of Materials Science, King Abdulaziz City for Science and Technology, Riyadh, Kingdom of Saudi Arabia; 2College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; 4Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi ArabiaCorrespondence: Nezar H Khdary, Institute of Materials Science, King Abdulaziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia, Tel +966-114814236, Email nkhdary@kacst.edu.sa Ibrahim O Alanazi, Aging institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia, Tel +966114813289, Email ialenazi@kacst.edu.saIntroduction: Herbs are excellent sources of medicinal substances, and their curative abilities have been recognized to treat many ailments and are used for example as antioxidants, analgesics, anti-inflammatories, antipyretics, and many other medicinal uses. The properties of natural compounds and their health effects have been studied extensively, especially those that originate from plant sources such as ginger. The ginger plant contains many chemical compounds, such as 6-gingerol, which is characterized by containing active groups such as carbonyl and hydroxide, which can be attached to metal molecules. This is what was done in this study, where the formation of complexes with a group of metals was studied and their effect on cancer cells was investigated. These complexes will open new horizons for further study of medicinal uses.Methods: The synthesis of gingerol-metal complexes was carried out by conjugating gingerol molecules with Ag, Au, Cd, Co, Cu, Ni, and Zn metal ions. The extracted gingerol was transferred to culture tubes and deionized water-DMSO were added followed by sonication. ... |
format |
Article in Journal/Newspaper |
author |
Khdary,Nezar H Alangari,Abdulaziz A Katubi,Khadijah M Alanazi,Mohammad Alhassan,Ahmed Alzahrani,Sami D Khan,Zahid Alanazi,Ibrahim O |
author_facet |
Khdary,Nezar H Alangari,Abdulaziz A Katubi,Khadijah M Alanazi,Mohammad Alhassan,Ahmed Alzahrani,Sami D Khan,Zahid Alanazi,Ibrahim O |
author_sort |
Khdary,Nezar H |
title |
Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line |
title_short |
Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line |
title_full |
Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line |
title_fullStr |
Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line |
title_full_unstemmed |
Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line |
title_sort |
synthesis of gingerol-metals complex and in-vitro cytotoxic activity on human colon cancer cell line |
publisher |
Dove Press |
publishDate |
2023 |
url |
https://www.dovepress.com/synthesis-of-gingerol-metals-complex-and-in-vitro-cytotoxic-activity-o-peer-reviewed-fulltext-article-CMAR |
genre |
sami sami |
genre_facet |
sami sami |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/CMAR.S391546 https://www.dovepress.com/synthesis-of-gingerol-metals-complex-and-in-vitro-cytotoxic-activity-o-peer-reviewed-fulltext-article-CMAR |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/CMAR.S391546 |
container_title |
Cancer Management and Research |
container_volume |
Volume 15 |
container_start_page |
87 |
op_container_end_page |
98 |
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1766185733478940672 |