Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population
Monica Zolezzi,1 Athar Elhakim,2 Waad M Elamin,1 Shorouk Homs,1 Doaa E Mahmoud,1 Iman A Qubaiah1 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2School of Health Sciences, College of North Atlantic Qatar, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, QU Health, Qatar...
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ftdovepress:oai:dovepress.com/70726 2023-05-15T17:35:57+02:00 Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population Zolezzi,Monica Elhakim,Athar Elamin,Waad M Homs,Shorouk Mahmoud,Doaa E Qubaiah,Iman A 2021-11-19 text/html https://www.dovepress.com/content-validation-of-an-algorithm-for-the-assessment-management-and-m-peer-reviewed-fulltext-article-NDT en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/NDT.S334350 https://www.dovepress.com/content-validation-of-an-algorithm-for-the-assessment-management-and-m-peer-reviewed-fulltext-article-NDT info:eu-repo/semantics/openAccess Neuropsychiatric Disease and Treatment Original Research info:eu-repo/semantics/article 2021 ftdovepress https://doi.org/10.2147/NDT.S334350 2022-12-27T23:22:02Z Monica Zolezzi,1 Athar Elhakim,2 Waad M Elamin,1 Shorouk Homs,1 Doaa E Mahmoud,1 Iman A Qubaiah1 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2School of Health Sciences, College of North Atlantic Qatar, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, QU Health, Qatar University, Doha, QatarTel +974 4403-5623Email mzolezzi@qu.edu.qaBackground: QTc interval (QTcI) prolongation leads to serious complications, making it a concern for clinicians. Assessing the risk of QTcI prolongation in the psychiatric population is important because they are exposed to multiple medications known to increase the risk of life-threatening arrhythmias.Aim: The study aims to validate the content of an algorithm for the assessment, management and monitoring of drug-induced QTc prolongation in the psychiatric population.Methodology: Qualitative semi-structured interviews of cardiologists, to gather information regarding their approach in assessing the risk of drug-induced QTc prolongation at the time of prescribing. After the interview, an orientation to the algorithm was provided with a link to a cross-sectional, anonymous survey. The online survey included quantitative and qualitative components to gather feedback on the relevance and appropriateness of each step in the algorithm.Results: Interview responses were incorporated into 4 themes. Responses indicated a lack of a unified protocol when assessing QTcI prolongation, which supports the need of an algorithm that includes a verified risk scoring tool. Quantitative survey results showed a mean score ranging from 3.08 to 3.67 out of 4 for the appropriateness of the algorithm’s steps, 3.08 to 3.58 for the safety and 3.17 to 3.75 for the reliability of references used. Additional analysis using the modified kappa and I-CVI statistical measures indicate high validity of contents and high degree of agreement between raters. As per the open-ended questions, cardiologists supported the implementation of the algorithm; however, they recommended simplification ... Article in Journal/Newspaper North Atlantic Dove Medical Press Neuropsychiatric Disease and Treatment Volume 17 3395 3405 |
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Neuropsychiatric Disease and Treatment Zolezzi,Monica Elhakim,Athar Elamin,Waad M Homs,Shorouk Mahmoud,Doaa E Qubaiah,Iman A Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population |
topic_facet |
Neuropsychiatric Disease and Treatment |
description |
Monica Zolezzi,1 Athar Elhakim,2 Waad M Elamin,1 Shorouk Homs,1 Doaa E Mahmoud,1 Iman A Qubaiah1 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2School of Health Sciences, College of North Atlantic Qatar, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, QU Health, Qatar University, Doha, QatarTel +974 4403-5623Email mzolezzi@qu.edu.qaBackground: QTc interval (QTcI) prolongation leads to serious complications, making it a concern for clinicians. Assessing the risk of QTcI prolongation in the psychiatric population is important because they are exposed to multiple medications known to increase the risk of life-threatening arrhythmias.Aim: The study aims to validate the content of an algorithm for the assessment, management and monitoring of drug-induced QTc prolongation in the psychiatric population.Methodology: Qualitative semi-structured interviews of cardiologists, to gather information regarding their approach in assessing the risk of drug-induced QTc prolongation at the time of prescribing. After the interview, an orientation to the algorithm was provided with a link to a cross-sectional, anonymous survey. The online survey included quantitative and qualitative components to gather feedback on the relevance and appropriateness of each step in the algorithm.Results: Interview responses were incorporated into 4 themes. Responses indicated a lack of a unified protocol when assessing QTcI prolongation, which supports the need of an algorithm that includes a verified risk scoring tool. Quantitative survey results showed a mean score ranging from 3.08 to 3.67 out of 4 for the appropriateness of the algorithm’s steps, 3.08 to 3.58 for the safety and 3.17 to 3.75 for the reliability of references used. Additional analysis using the modified kappa and I-CVI statistical measures indicate high validity of contents and high degree of agreement between raters. As per the open-ended questions, cardiologists supported the implementation of the algorithm; however, they recommended simplification ... |
format |
Article in Journal/Newspaper |
author |
Zolezzi,Monica Elhakim,Athar Elamin,Waad M Homs,Shorouk Mahmoud,Doaa E Qubaiah,Iman A |
author_facet |
Zolezzi,Monica Elhakim,Athar Elamin,Waad M Homs,Shorouk Mahmoud,Doaa E Qubaiah,Iman A |
author_sort |
Zolezzi,Monica |
title |
Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population |
title_short |
Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population |
title_full |
Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population |
title_fullStr |
Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population |
title_full_unstemmed |
Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population |
title_sort |
content validation of an algorithm for the assessment, management and monitoring of drug-induced qtc prolongation in the psychiatric population |
publisher |
Dove Press |
publishDate |
2021 |
url |
https://www.dovepress.com/content-validation-of-an-algorithm-for-the-assessment-management-and-m-peer-reviewed-fulltext-article-NDT |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/NDT.S334350 https://www.dovepress.com/content-validation-of-an-algorithm-for-the-assessment-management-and-m-peer-reviewed-fulltext-article-NDT |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/NDT.S334350 |
container_title |
Neuropsychiatric Disease and Treatment |
container_volume |
Volume 17 |
container_start_page |
3395 |
op_container_end_page |
3405 |
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1766135269439832064 |