Reproductive Factors, Use of Exogenous Hormones, and Pancreatic Cancer Incidence: The Norwegian Women and Cancer Study
Antoine Alvarez,1 Kristin Benjaminsen Borch,2 Charlotta Rylander2 1Faculty of Medicine, Paris-Sud University, Paris, France; 2Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, NorwayCorrespondence: Charlotta RylanderDepartment of Community Med...
Published in: | Clinical Epidemiology |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Dove Press
2021
|
Subjects: | |
Online Access: | https://www.dovepress.com/reproductive-factors-use-of-exogenous-hormones-and-pancreatic-cancer-i-peer-reviewed-fulltext-article-CLEP |
id |
ftdovepress:oai:dovepress.com/61774 |
---|---|
record_format |
openpolar |
spelling |
ftdovepress:oai:dovepress.com/61774 2023-05-15T18:34:28+02:00 Reproductive Factors, Use of Exogenous Hormones, and Pancreatic Cancer Incidence: The Norwegian Women and Cancer Study Alvarez,Antoine Benjaminsen Borch,Kristin Rylander,Charlotta 2021-02-05 text/html https://www.dovepress.com/reproductive-factors-use-of-exogenous-hormones-and-pancreatic-cancer-i-peer-reviewed-fulltext-article-CLEP en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/CLEP.S268556 https://www.dovepress.com/reproductive-factors-use-of-exogenous-hormones-and-pancreatic-cancer-i-peer-reviewed-fulltext-article-CLEP info:eu-repo/semantics/openAccess Clinical Epidemiology Original Research info:eu-repo/semantics/article 2021 ftdovepress https://doi.org/10.2147/CLEP.S268556 2022-12-27T23:05:30Z Antoine Alvarez,1 Kristin Benjaminsen Borch,2 Charlotta Rylander2 1Faculty of Medicine, Paris-Sud University, Paris, France; 2Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, NorwayCorrespondence: Charlotta RylanderDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, 9037, NorwayTel +47-77-644-831Email charlotta.rylander@uit.noIntroduction: The incidence of pancreatic cancer is increasing worldwide and characterized by a particularly low survival rate. Studies have reported weak and inconsistent evidence for associations among reproductive factors, use of exogenous hormones, and pancreatic cancer incidence in women.Purpose: To investigate relationships between reproductive factors, exogenous hormones, and the rate of pancreatic cancer incidence in a large population-based prospective cohort of women in Norway.Methods: We used data from the Norwegian Women and Cancer study on 588 incident cases of pancreatic cancer diagnosed among 165,419 women, with mean follow-up of 18.7 years. Cox proportional-hazard models were used to estimate HRs and 95% CIs for associations of interest.Results: Cumulative breastfeeding duration > 24 months was associated with 63% decreased incidence of pancreatic cancer compared to no breastfeeding. We observed an inverse linear dose–response trend between cumulative breastfeeding duration and pancreatic cancer incidence, which was confirmed in parous women and ever-smokers. Higher age at first birth and menopause were inversely associated with pancreatic cancer incidence, though with less precise effect estimates. Current use of oral contraceptives was associated with a doubling of pancreatic cancer incidence, but the analysis was hampered by a small number of cases. There was no evidence of any associations between age at menarche, parity or use of menopausal hormone therapy, and incidence of pancreatic cancer.Conclusion: Our results suggest a potential protective effect of ... Article in Journal/Newspaper Tromsø Arctic University of Norway UiT The Arctic University of Norway Dove Medical Press Alvarez ENVELOPE(-64.483,-64.483,-65.633,-65.633) Arctic Norway Tromsø Clinical Epidemiology Volume 13 67 80 |
institution |
Open Polar |
collection |
Dove Medical Press |
op_collection_id |
ftdovepress |
language |
English |
topic |
Clinical Epidemiology |
spellingShingle |
Clinical Epidemiology Alvarez,Antoine Benjaminsen Borch,Kristin Rylander,Charlotta Reproductive Factors, Use of Exogenous Hormones, and Pancreatic Cancer Incidence: The Norwegian Women and Cancer Study |
topic_facet |
Clinical Epidemiology |
description |
Antoine Alvarez,1 Kristin Benjaminsen Borch,2 Charlotta Rylander2 1Faculty of Medicine, Paris-Sud University, Paris, France; 2Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, NorwayCorrespondence: Charlotta RylanderDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, 9037, NorwayTel +47-77-644-831Email charlotta.rylander@uit.noIntroduction: The incidence of pancreatic cancer is increasing worldwide and characterized by a particularly low survival rate. Studies have reported weak and inconsistent evidence for associations among reproductive factors, use of exogenous hormones, and pancreatic cancer incidence in women.Purpose: To investigate relationships between reproductive factors, exogenous hormones, and the rate of pancreatic cancer incidence in a large population-based prospective cohort of women in Norway.Methods: We used data from the Norwegian Women and Cancer study on 588 incident cases of pancreatic cancer diagnosed among 165,419 women, with mean follow-up of 18.7 years. Cox proportional-hazard models were used to estimate HRs and 95% CIs for associations of interest.Results: Cumulative breastfeeding duration > 24 months was associated with 63% decreased incidence of pancreatic cancer compared to no breastfeeding. We observed an inverse linear dose–response trend between cumulative breastfeeding duration and pancreatic cancer incidence, which was confirmed in parous women and ever-smokers. Higher age at first birth and menopause were inversely associated with pancreatic cancer incidence, though with less precise effect estimates. Current use of oral contraceptives was associated with a doubling of pancreatic cancer incidence, but the analysis was hampered by a small number of cases. There was no evidence of any associations between age at menarche, parity or use of menopausal hormone therapy, and incidence of pancreatic cancer.Conclusion: Our results suggest a potential protective effect of ... |
format |
Article in Journal/Newspaper |
author |
Alvarez,Antoine Benjaminsen Borch,Kristin Rylander,Charlotta |
author_facet |
Alvarez,Antoine Benjaminsen Borch,Kristin Rylander,Charlotta |
author_sort |
Alvarez,Antoine |
title |
Reproductive Factors, Use of Exogenous Hormones, and Pancreatic Cancer Incidence: The Norwegian Women and Cancer Study |
title_short |
Reproductive Factors, Use of Exogenous Hormones, and Pancreatic Cancer Incidence: The Norwegian Women and Cancer Study |
title_full |
Reproductive Factors, Use of Exogenous Hormones, and Pancreatic Cancer Incidence: The Norwegian Women and Cancer Study |
title_fullStr |
Reproductive Factors, Use of Exogenous Hormones, and Pancreatic Cancer Incidence: The Norwegian Women and Cancer Study |
title_full_unstemmed |
Reproductive Factors, Use of Exogenous Hormones, and Pancreatic Cancer Incidence: The Norwegian Women and Cancer Study |
title_sort |
reproductive factors, use of exogenous hormones, and pancreatic cancer incidence: the norwegian women and cancer study |
publisher |
Dove Press |
publishDate |
2021 |
url |
https://www.dovepress.com/reproductive-factors-use-of-exogenous-hormones-and-pancreatic-cancer-i-peer-reviewed-fulltext-article-CLEP |
long_lat |
ENVELOPE(-64.483,-64.483,-65.633,-65.633) |
geographic |
Alvarez Arctic Norway Tromsø |
geographic_facet |
Alvarez Arctic Norway Tromsø |
genre |
Tromsø Arctic University of Norway UiT The Arctic University of Norway |
genre_facet |
Tromsø Arctic University of Norway UiT The Arctic University of Norway |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/CLEP.S268556 https://www.dovepress.com/reproductive-factors-use-of-exogenous-hormones-and-pancreatic-cancer-i-peer-reviewed-fulltext-article-CLEP |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/CLEP.S268556 |
container_title |
Clinical Epidemiology |
container_volume |
Volume 13 |
container_start_page |
67 |
op_container_end_page |
80 |
_version_ |
1766219216662298624 |