Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients
Fatemeh Saheb Sharif-Askari,1 Narjes Saheb Sharif-Askari,1 Adnane Guella,2 Ali Alabdullah,1,* Hour Bashar Al Sheleh,1,* Afnan Maher Hoory AlRawi,1,* Enad Sami Haddad,1,* Qutayba Hamid,1,3 Rabih Halwani,1,3,4 Rifat Hamoudi1,3 1Sharjah Institute of Medical Research, College of Medicine, University of...
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ftdovepress:oai:dovepress.com/54787 2023-05-15T18:13:15+02:00 Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients Saheb Sharif-Askari,Fatemeh Saheb Sharif-Askari,Narjes Guella,Adnane Alabdullah,Ali Bashar Al Sheleh,Hour Maher Hoory AlRawi,Afnan Sami Haddad,Enad Hamid,Qutayba Halwani,Rabih Hamoudi,Rifat 2020-06-24 text/html https://www.dovepress.com/blood-neutrophil-to-lymphocyte-ratio-and-urine-il-8-levels-predict-the-peer-reviewed-fulltext-article-IDR en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/IDR.S251966 https://www.dovepress.com/blood-neutrophil-to-lymphocyte-ratio-and-urine-il-8-levels-predict-the-peer-reviewed-fulltext-article-IDR info:eu-repo/semantics/openAccess Infection and Drug Resistance Original Research info:eu-repo/semantics/article 2020 ftdovepress https://doi.org/10.2147/IDR.S251966 2022-12-27T22:52:34Z Fatemeh Saheb Sharif-Askari,1 Narjes Saheb Sharif-Askari,1 Adnane Guella,2 Ali Alabdullah,1,* Hour Bashar Al Sheleh,1,* Afnan Maher Hoory AlRawi,1,* Enad Sami Haddad,1,* Qutayba Hamid,1,3 Rabih Halwani,1,3,4 Rifat Hamoudi1,3 1Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 2Department of Nephrology, University Hospital Sharjah, Sharjah, United Arab Emirates; 3Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 4Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Rifat Hamoudi; Rabih HalwaniCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesEmail rhamoudi@sharjah.ac.ae; rhalwani@sharjah.ac.aeBackground: Extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are the most common uropathogens causing UTI (urinary tract infection) in type 2 diabetes mellitus (T2DM). Circulatory inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are usually dysregulated during UTI. However, the differential regulation of these inflammatory signatures during E. coli and K. pneumoniae UTI in T2DM has not been determined.Methods: A case–control study on 466 patients was performed to investigate the inflammatory signatures indicative of ESBL-E. coli and K. pneumoniae UTIs in T2DM. Serum CRP levels and blood NLR for these patients were determined and associated with E. coli and K. pneumoniae ESBL uropathogen using multivariate logistic regression analysis. Urinary interleukin 8 (IL-8) levels were also assessed and associated with these two UTI uropathogens in T2DM. The association of the two ESBL-uropathogens with the survival outcomes of T2DM patients was also analyzed using Cox-proportional hazard model.Results: T2DM patients with ESBL-E. ... Article in Journal/Newspaper sami Dove Medical Press Maher ENVELOPE(-81.183,-81.183,51.067,51.067) Infection and Drug Resistance Volume 13 1961 1970 |
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Dove Medical Press |
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English |
topic |
Infection and Drug Resistance |
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Infection and Drug Resistance Saheb Sharif-Askari,Fatemeh Saheb Sharif-Askari,Narjes Guella,Adnane Alabdullah,Ali Bashar Al Sheleh,Hour Maher Hoory AlRawi,Afnan Sami Haddad,Enad Hamid,Qutayba Halwani,Rabih Hamoudi,Rifat Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients |
topic_facet |
Infection and Drug Resistance |
description |
Fatemeh Saheb Sharif-Askari,1 Narjes Saheb Sharif-Askari,1 Adnane Guella,2 Ali Alabdullah,1,* Hour Bashar Al Sheleh,1,* Afnan Maher Hoory AlRawi,1,* Enad Sami Haddad,1,* Qutayba Hamid,1,3 Rabih Halwani,1,3,4 Rifat Hamoudi1,3 1Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 2Department of Nephrology, University Hospital Sharjah, Sharjah, United Arab Emirates; 3Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 4Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Rifat Hamoudi; Rabih HalwaniCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesEmail rhamoudi@sharjah.ac.ae; rhalwani@sharjah.ac.aeBackground: Extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are the most common uropathogens causing UTI (urinary tract infection) in type 2 diabetes mellitus (T2DM). Circulatory inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are usually dysregulated during UTI. However, the differential regulation of these inflammatory signatures during E. coli and K. pneumoniae UTI in T2DM has not been determined.Methods: A case–control study on 466 patients was performed to investigate the inflammatory signatures indicative of ESBL-E. coli and K. pneumoniae UTIs in T2DM. Serum CRP levels and blood NLR for these patients were determined and associated with E. coli and K. pneumoniae ESBL uropathogen using multivariate logistic regression analysis. Urinary interleukin 8 (IL-8) levels were also assessed and associated with these two UTI uropathogens in T2DM. The association of the two ESBL-uropathogens with the survival outcomes of T2DM patients was also analyzed using Cox-proportional hazard model.Results: T2DM patients with ESBL-E. ... |
format |
Article in Journal/Newspaper |
author |
Saheb Sharif-Askari,Fatemeh Saheb Sharif-Askari,Narjes Guella,Adnane Alabdullah,Ali Bashar Al Sheleh,Hour Maher Hoory AlRawi,Afnan Sami Haddad,Enad Hamid,Qutayba Halwani,Rabih Hamoudi,Rifat |
author_facet |
Saheb Sharif-Askari,Fatemeh Saheb Sharif-Askari,Narjes Guella,Adnane Alabdullah,Ali Bashar Al Sheleh,Hour Maher Hoory AlRawi,Afnan Sami Haddad,Enad Hamid,Qutayba Halwani,Rabih Hamoudi,Rifat |
author_sort |
Saheb Sharif-Askari,Fatemeh |
title |
Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients |
title_short |
Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients |
title_full |
Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients |
title_fullStr |
Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients |
title_full_unstemmed |
Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients |
title_sort |
blood neutrophil-to-lymphocyte ratio and urine il-8 levels predict the type of bacterial urinary tract infection in type 2 diabetes mellitus patients |
publisher |
Dove Press |
publishDate |
2020 |
url |
https://www.dovepress.com/blood-neutrophil-to-lymphocyte-ratio-and-urine-il-8-levels-predict-the-peer-reviewed-fulltext-article-IDR |
long_lat |
ENVELOPE(-81.183,-81.183,51.067,51.067) |
geographic |
Maher |
geographic_facet |
Maher |
genre |
sami |
genre_facet |
sami |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/IDR.S251966 https://www.dovepress.com/blood-neutrophil-to-lymphocyte-ratio-and-urine-il-8-levels-predict-the-peer-reviewed-fulltext-article-IDR |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/IDR.S251966 |
container_title |
Infection and Drug Resistance |
container_volume |
Volume 13 |
container_start_page |
1961 |
op_container_end_page |
1970 |
_version_ |
1766185758152982528 |