Recruitment and inclusion procedures as “pain killers” in clinical trials?
H Nothnagel,1–3 M Brown Menard4,5, G Kvarstein,6 AJ Norheim,3 T Weiss,7 C Puta1,8, SD Mist,9 F Musial31Department of Sports Medicine and Health Promotion, Friedrich Schiller University Jena, Jena, Germany; 2Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; 3Departm...
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ftdovepress:oai:dovepress.com/46811 2023-05-15T17:43:36+02:00 Recruitment and inclusion procedures as “pain killers” in clinical trials? Nothnagel,Helen Menard,Martha Brown Kvarstein,Gunnvald Norheim,Arne Johan Weiss,Thomas Puta,Christian Mist,Scott Musial,Frauke 2019-07-03 text/html https://www.dovepress.com/recruitment-and-inclusion-procedures-as-pain-killers-in-clinical-trial-peer-reviewed-fulltext-article-JPR en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/JPR.S204259 https://www.dovepress.com/recruitment-and-inclusion-procedures-as-pain-killers-in-clinical-trial-peer-reviewed-fulltext-article-JPR info:eu-repo/semantics/openAccess Journal of Pain Research Original Research info:eu-repo/semantics/article 2019 ftdovepress https://doi.org/10.2147/JPR.S204259 2022-12-27T22:37:56Z H Nothnagel,1–3 M Brown Menard4,5, G Kvarstein,6 AJ Norheim,3 T Weiss,7 C Puta1,8, SD Mist,9 F Musial31Department of Sports Medicine and Health Promotion, Friedrich Schiller University Jena, Jena, Germany; 2Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; 3Department of Community Medicine, The National Research Center for Complementary and Alternative Medicine (NAFKAM), UiT The Arctic University of Norway, Tromsø, Norway; 4Crocker Institute, Kiawah Island, SC, USA; 5School of Integrative Medicine and Health Sciences, Saybrook University, Oakland, CA, USA; 6Pain clinic, University Hospital of Northern Norway, UiT The Arctic University of Norway, Tromsø, Norway; 7Department of Biological and Clinical Psychology, Friedrich Schiller University, Jena, Germany; 8Center for Interdisciplinary Prevention of Diseases related to Professional Activities, Friedrich Schiller University, Jena, Germany; 9Oregon Health & Science University, Portland, OR, USABackground: Recruitment and inclusion procedures in clinical trials are time critical. This holds particularly true for studies investigating patients with fluctuating symptom patterns, like those with chronic neck pain. In a feasibility study on neck pain, we found a clinically relevant decrease in pain ratings within the recruitment period. This paper analyses the phenomenon and gives recommendations for recruitment procedures in clinical trials on pain.Methods: Changes in pain intensity scores of 44 chronic neck pain patients (6 males and 36 females; mean age: 45.3±13.2 years) between the first telephone contact and baseline assessment were analyzed. Inclusion criterion was a mean pain intensity of ≥40 on a 0–100 numerical rating scale during the last three months. Statistical analyses were performed using ANOVA and parametric/non-parametric correlation coefficients.Results: Average pain intensity score decreased significantly from 60.3±13.3 at telephone interview to 38.1±21.7 at baseline assessment. This represents a relative change ... Article in Journal/Newspaper Northern Norway Tromsø Arctic University of Norway UiT The Arctic University of Norway Dove Medical Press Arctic Norway Tromsø Journal of Pain Research Volume 12 2027 2037 |
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Journal of Pain Research Nothnagel,Helen Menard,Martha Brown Kvarstein,Gunnvald Norheim,Arne Johan Weiss,Thomas Puta,Christian Mist,Scott Musial,Frauke Recruitment and inclusion procedures as “pain killers” in clinical trials? |
topic_facet |
Journal of Pain Research |
description |
H Nothnagel,1–3 M Brown Menard4,5, G Kvarstein,6 AJ Norheim,3 T Weiss,7 C Puta1,8, SD Mist,9 F Musial31Department of Sports Medicine and Health Promotion, Friedrich Schiller University Jena, Jena, Germany; 2Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; 3Department of Community Medicine, The National Research Center for Complementary and Alternative Medicine (NAFKAM), UiT The Arctic University of Norway, Tromsø, Norway; 4Crocker Institute, Kiawah Island, SC, USA; 5School of Integrative Medicine and Health Sciences, Saybrook University, Oakland, CA, USA; 6Pain clinic, University Hospital of Northern Norway, UiT The Arctic University of Norway, Tromsø, Norway; 7Department of Biological and Clinical Psychology, Friedrich Schiller University, Jena, Germany; 8Center for Interdisciplinary Prevention of Diseases related to Professional Activities, Friedrich Schiller University, Jena, Germany; 9Oregon Health & Science University, Portland, OR, USABackground: Recruitment and inclusion procedures in clinical trials are time critical. This holds particularly true for studies investigating patients with fluctuating symptom patterns, like those with chronic neck pain. In a feasibility study on neck pain, we found a clinically relevant decrease in pain ratings within the recruitment period. This paper analyses the phenomenon and gives recommendations for recruitment procedures in clinical trials on pain.Methods: Changes in pain intensity scores of 44 chronic neck pain patients (6 males and 36 females; mean age: 45.3±13.2 years) between the first telephone contact and baseline assessment were analyzed. Inclusion criterion was a mean pain intensity of ≥40 on a 0–100 numerical rating scale during the last three months. Statistical analyses were performed using ANOVA and parametric/non-parametric correlation coefficients.Results: Average pain intensity score decreased significantly from 60.3±13.3 at telephone interview to 38.1±21.7 at baseline assessment. This represents a relative change ... |
format |
Article in Journal/Newspaper |
author |
Nothnagel,Helen Menard,Martha Brown Kvarstein,Gunnvald Norheim,Arne Johan Weiss,Thomas Puta,Christian Mist,Scott Musial,Frauke |
author_facet |
Nothnagel,Helen Menard,Martha Brown Kvarstein,Gunnvald Norheim,Arne Johan Weiss,Thomas Puta,Christian Mist,Scott Musial,Frauke |
author_sort |
Nothnagel,Helen |
title |
Recruitment and inclusion procedures as “pain killers” in clinical trials? |
title_short |
Recruitment and inclusion procedures as “pain killers” in clinical trials? |
title_full |
Recruitment and inclusion procedures as “pain killers” in clinical trials? |
title_fullStr |
Recruitment and inclusion procedures as “pain killers” in clinical trials? |
title_full_unstemmed |
Recruitment and inclusion procedures as “pain killers” in clinical trials? |
title_sort |
recruitment and inclusion procedures as “pain killers” in clinical trials? |
publisher |
Dove Press |
publishDate |
2019 |
url |
https://www.dovepress.com/recruitment-and-inclusion-procedures-as-pain-killers-in-clinical-trial-peer-reviewed-fulltext-article-JPR |
geographic |
Arctic Norway Tromsø |
geographic_facet |
Arctic Norway Tromsø |
genre |
Northern Norway Tromsø Arctic University of Norway UiT The Arctic University of Norway |
genre_facet |
Northern Norway Tromsø Arctic University of Norway UiT The Arctic University of Norway |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/JPR.S204259 https://www.dovepress.com/recruitment-and-inclusion-procedures-as-pain-killers-in-clinical-trial-peer-reviewed-fulltext-article-JPR |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/JPR.S204259 |
container_title |
Journal of Pain Research |
container_volume |
Volume 12 |
container_start_page |
2027 |
op_container_end_page |
2037 |
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1766145728244088832 |