Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration
Tijana Drobnjak,1 Anna Margrét Jónsdóttir,2 Helga Helgadóttir,1 Margrét Soffía Runólfsdóttir,1 Hamutal Meiri,3,4 Marei Sammar,5 George Osol,6 Maurizio Mandalà,7 Berthold Huppertz,8 Sveinbjörn Gizurarson1 1Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik,...
Published in: | International Journal of Women's Health |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Dove Press
2019
|
Subjects: | |
Online Access: | https://www.dovepress.com/placental-protein-13-pp13-stimulates-rat-uterine-vessels-after-slow-su-peer-reviewed-fulltext-article-IJWH |
id |
ftdovepress:oai:dovepress.com/44797 |
---|---|
record_format |
openpolar |
spelling |
ftdovepress:oai:dovepress.com/44797 2023-05-15T16:46:45+02:00 Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration Drobnjak,Tijana Jónsdóttir,Anna Margrét Helgadóttir,Helga Runólfsdóttir,Margrét SoffÃa Meiri,Hamutal Sammar,Marei Osol,George Mandalà ,Maurizio Huppertz,Berthold Gizurarson,Sveinbjörn 2019-03-27 text/html https://www.dovepress.com/placental-protein-13-pp13-stimulates-rat-uterine-vessels-after-slow-su-peer-reviewed-fulltext-article-IJWH en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/IJWH.S188303 https://www.dovepress.com/placental-protein-13-pp13-stimulates-rat-uterine-vessels-after-slow-su-peer-reviewed-fulltext-article-IJWH info:eu-repo/semantics/openAccess International Journal of Women's Health Original Research info:eu-repo/semantics/article 2019 ftdovepress https://doi.org/10.2147/IJWH.S188303 2022-12-27T22:34:16Z Tijana Drobnjak,1 Anna Margrét Jónsdóttir,2 Helga Helgadóttir,1 Margrét Soffía Runólfsdóttir,1 Hamutal Meiri,3,4 Marei Sammar,5 George Osol,6 Maurizio Mandalà,7 Berthold Huppertz,8 Sveinbjörn Gizurarson1 1Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik, Iceland; 2Department of Pathology, University Hospital Iceland, Reykjavik, Iceland; 3Hy Laboratories Ltd, Rehovot, Israel; 4TeleMarpe Ltd., Tel Aviv, Israel; 5Ephraim Katzir Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel; 6Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA; 7Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy; 8Department of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria Introduction: Reduced concentrations of placental protein 13 (PP13) during the first trimester of human pregnancy are associated with elevated risk for the subsequent development of preeclampsia, which is one of the deadliest obstetrical complications of pregnancy. Previous studies by our group have shown that PP13 lowers blood pressure in pregnant rats, increases the size and weight of pups and placentas, and induces vasodilation of resistance arteries through endothelial signaling pathways involving endothelial nitric oxid synthase and prostaglandin. Methods: In the present study, the effect of PP13 was investigated in nonpregnant female Sprague Dawley rats (n=27). Osmotic pumps were surgically implanted subcutaneously that released a constant dose of PP13 or saline over 7 days. Most animals were sacrificed 6 days after the end of PP13 release (on day 13), while some were sacrificed immediately at the end of day 7 (the last PP13 release day), to compare the short- and long-term impact of PP13 on vessels’ growth and size. Results: The uterine vessels were significantly expanded in the group exposed to recombinant PP13 (rPP13) ... Article in Journal/Newspaper Iceland Dove Medical Press Burlington ENVELOPE(-56.015,-56.015,49.750,49.750) International Journal of Women's Health Volume 11 213 222 |
institution |
Open Polar |
collection |
Dove Medical Press |
op_collection_id |
ftdovepress |
language |
English |
topic |
International Journal of Women's Health |
spellingShingle |
International Journal of Women's Health Drobnjak,Tijana Jónsdóttir,Anna Margrét Helgadóttir,Helga Runólfsdóttir,Margrét SoffÃa Meiri,Hamutal Sammar,Marei Osol,George Mandalà ,Maurizio Huppertz,Berthold Gizurarson,Sveinbjörn Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration |
topic_facet |
International Journal of Women's Health |
description |
Tijana Drobnjak,1 Anna Margrét Jónsdóttir,2 Helga Helgadóttir,1 Margrét Soffía Runólfsdóttir,1 Hamutal Meiri,3,4 Marei Sammar,5 George Osol,6 Maurizio Mandalà,7 Berthold Huppertz,8 Sveinbjörn Gizurarson1 1Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik, Iceland; 2Department of Pathology, University Hospital Iceland, Reykjavik, Iceland; 3Hy Laboratories Ltd, Rehovot, Israel; 4TeleMarpe Ltd., Tel Aviv, Israel; 5Ephraim Katzir Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel; 6Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA; 7Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy; 8Department of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria Introduction: Reduced concentrations of placental protein 13 (PP13) during the first trimester of human pregnancy are associated with elevated risk for the subsequent development of preeclampsia, which is one of the deadliest obstetrical complications of pregnancy. Previous studies by our group have shown that PP13 lowers blood pressure in pregnant rats, increases the size and weight of pups and placentas, and induces vasodilation of resistance arteries through endothelial signaling pathways involving endothelial nitric oxid synthase and prostaglandin. Methods: In the present study, the effect of PP13 was investigated in nonpregnant female Sprague Dawley rats (n=27). Osmotic pumps were surgically implanted subcutaneously that released a constant dose of PP13 or saline over 7 days. Most animals were sacrificed 6 days after the end of PP13 release (on day 13), while some were sacrificed immediately at the end of day 7 (the last PP13 release day), to compare the short- and long-term impact of PP13 on vessels’ growth and size. Results: The uterine vessels were significantly expanded in the group exposed to recombinant PP13 (rPP13) ... |
format |
Article in Journal/Newspaper |
author |
Drobnjak,Tijana Jónsdóttir,Anna Margrét Helgadóttir,Helga Runólfsdóttir,Margrét SoffÃa Meiri,Hamutal Sammar,Marei Osol,George Mandalà ,Maurizio Huppertz,Berthold Gizurarson,Sveinbjörn |
author_facet |
Drobnjak,Tijana Jónsdóttir,Anna Margrét Helgadóttir,Helga Runólfsdóttir,Margrét SoffÃa Meiri,Hamutal Sammar,Marei Osol,George Mandalà ,Maurizio Huppertz,Berthold Gizurarson,Sveinbjörn |
author_sort |
Drobnjak,Tijana |
title |
Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration |
title_short |
Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration |
title_full |
Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration |
title_fullStr |
Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration |
title_full_unstemmed |
Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration |
title_sort |
placental protein 13 (pp13) stimulates rat uterine vessels after slow subcutaneous administration |
publisher |
Dove Press |
publishDate |
2019 |
url |
https://www.dovepress.com/placental-protein-13-pp13-stimulates-rat-uterine-vessels-after-slow-su-peer-reviewed-fulltext-article-IJWH |
long_lat |
ENVELOPE(-56.015,-56.015,49.750,49.750) |
geographic |
Burlington |
geographic_facet |
Burlington |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/IJWH.S188303 https://www.dovepress.com/placental-protein-13-pp13-stimulates-rat-uterine-vessels-after-slow-su-peer-reviewed-fulltext-article-IJWH |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/IJWH.S188303 |
container_title |
International Journal of Women's Health |
container_volume |
Volume 11 |
container_start_page |
213 |
op_container_end_page |
222 |
_version_ |
1766036851933577216 |