Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits
Tijana Drobnjak,1 Hamutal Meiri,2,3 Maurizio Mandalá,4 Berthold Huppertz,5 Sveinbjörn Gizurarson1 1Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Reykjavik, Iceland; 2Hy Laboratories, Rehovot, Israel; 3TeleMarpe Ltd., Tel Aviv, Israel; 4Department of Biology, E...
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ftdovepress:oai:dovepress.com/39115 2023-05-15T16:48:10+02:00 Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits Drobnjak,Tijana Meiri,Hamutal Mandalá,Maurizio Huppertz,Berthold Gizurarson,Sveinbjörn 2018-07-03 text/html https://www.dovepress.com/pharmacokinetics-of-placental-protein-13-after-intravenous-and-subcuta-peer-reviewed-fulltext-article-DDDT en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/DDDT.S167926 https://www.dovepress.com/pharmacokinetics-of-placental-protein-13-after-intravenous-and-subcuta-peer-reviewed-fulltext-article-DDDT info:eu-repo/semantics/openAccess Drug Design Development and Therapy Original Research info:eu-repo/semantics/article 2018 ftdovepress https://doi.org/10.2147/DDDT.S167926 2022-12-27T22:23:54Z Tijana Drobnjak,1 Hamutal Meiri,2,3 Maurizio Mandalá,4 Berthold Huppertz,5 Sveinbjörn Gizurarson1 1Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Reykjavik, Iceland; 2Hy Laboratories, Rehovot, Israel; 3TeleMarpe Ltd., Tel Aviv, Israel; 4Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy; 5Department of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria Introduction: Human placental protein 13 (PP13) is a galectin predominantly expressed by the placenta. Low serum concentrations of PP13 in early pregnancy indicate a higher risk of developing preeclampsia. Methods: The pharmacokinetic disposition and bioavailability of PP13 were determined by single intravenous and subcutaneous administration to 12 healthy New Zealand White rabbits. The serum pharmacokinetic values were determined by enzyme-linked immunosorbent assay, and are best described by a two-compartment model. Results: Both volume of distribution and the area under the curve were dose dependent for the intravenous group (p<0.01). PP13 elimination half-life was also found to be different between the groups (p<0.01). The bioavailability of PP13 following subcutaneous administration was found to be 57%. Conclusion: This study shows that the concentration of total PP13 released into the maternal circulation during pregnancy might be much higher than previously estimated. Keywords: PP13, ELISA, PK, eNOS, prostaglandin, preeclampsia Article in Journal/Newspaper Iceland Dove Medical Press New Zealand Drug Design, Development and Therapy Volume 12 1977 1983 |
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Drug Design Development and Therapy Drobnjak,Tijana Meiri,Hamutal Mandalá,Maurizio Huppertz,Berthold Gizurarson,Sveinbjörn Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits |
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Drug Design Development and Therapy |
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Tijana Drobnjak,1 Hamutal Meiri,2,3 Maurizio Mandalá,4 Berthold Huppertz,5 Sveinbjörn Gizurarson1 1Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Reykjavik, Iceland; 2Hy Laboratories, Rehovot, Israel; 3TeleMarpe Ltd., Tel Aviv, Israel; 4Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy; 5Department of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria Introduction: Human placental protein 13 (PP13) is a galectin predominantly expressed by the placenta. Low serum concentrations of PP13 in early pregnancy indicate a higher risk of developing preeclampsia. Methods: The pharmacokinetic disposition and bioavailability of PP13 were determined by single intravenous and subcutaneous administration to 12 healthy New Zealand White rabbits. The serum pharmacokinetic values were determined by enzyme-linked immunosorbent assay, and are best described by a two-compartment model. Results: Both volume of distribution and the area under the curve were dose dependent for the intravenous group (p<0.01). PP13 elimination half-life was also found to be different between the groups (p<0.01). The bioavailability of PP13 following subcutaneous administration was found to be 57%. Conclusion: This study shows that the concentration of total PP13 released into the maternal circulation during pregnancy might be much higher than previously estimated. Keywords: PP13, ELISA, PK, eNOS, prostaglandin, preeclampsia |
format |
Article in Journal/Newspaper |
author |
Drobnjak,Tijana Meiri,Hamutal Mandalá,Maurizio Huppertz,Berthold Gizurarson,Sveinbjörn |
author_facet |
Drobnjak,Tijana Meiri,Hamutal Mandalá,Maurizio Huppertz,Berthold Gizurarson,Sveinbjörn |
author_sort |
Drobnjak,Tijana |
title |
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits |
title_short |
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits |
title_full |
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits |
title_fullStr |
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits |
title_full_unstemmed |
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits |
title_sort |
pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits |
publisher |
Dove Press |
publishDate |
2018 |
url |
https://www.dovepress.com/pharmacokinetics-of-placental-protein-13-after-intravenous-and-subcuta-peer-reviewed-fulltext-article-DDDT |
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New Zealand |
geographic_facet |
New Zealand |
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Iceland |
genre_facet |
Iceland |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/DDDT.S167926 https://www.dovepress.com/pharmacokinetics-of-placental-protein-13-after-intravenous-and-subcuta-peer-reviewed-fulltext-article-DDDT |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/DDDT.S167926 |
container_title |
Drug Design, Development and Therapy |
container_volume |
Volume 12 |
container_start_page |
1977 |
op_container_end_page |
1983 |
_version_ |
1766038273274150912 |