Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4
Sami A Gabr,1,2 Ahmad H Alghadir,1 Ahmed A Allam,3,4 Jamaan Ajarem,3 Ghada Al-Basher,3 Mostafa A Abdel-Maksoud,3 Ayman A Ghfar,5 Alaa Aboud6 1Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Department of Anatomy, Faculty of...
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ftdovepress:oai:dovepress.com/26751 2023-05-15T18:13:26+02:00 Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4 Gabr,Sami Alghadir,Ahmad Allam,Ahmed Ajarem,Jamaan Al-Basher,Ghada Abdel-Maksoud,Mostafa Ghfar,Ayman Aboud,Alaa 2016-05-04 text/html https://www.dovepress.com/correlation-between-vitamin-d-levels-and-apoptosis-in-geriatric-patien-peer-reviewed-fulltext-article-CIA en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/CIA.S104599 https://www.dovepress.com/correlation-between-vitamin-d-levels-and-apoptosis-in-geriatric-patien-peer-reviewed-fulltext-article-CIA info:eu-repo/semantics/openAccess Clinical Interventions in Aging Original Research info:eu-repo/semantics/article 2016 ftdovepress https://doi.org/10.2147/CIA.S104599 2022-12-27T22:01:16Z Sami A Gabr,1,2 Ahmad H Alghadir,1 Ahmed A Allam,3,4 Jamaan Ajarem,3 Ghada Al-Basher,3 Mostafa A Abdel-Maksoud,3 Ayman A Ghfar,5 Alaa Aboud6 1Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; 4Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt; 5Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 6Internal Endemic Medicine Department, College of Medicine, Beni-Suef University, Beni Suef, Egypt Background: Vitamin D levels play a pivotal role in most biological processes and differ according to age. A deficiency of vitamin D in chronic hepatitis C (CHC) patients has been shown to be linked with the severity of liver fibrosis, but little is known about the mechanism of this association. Objective: In this study, we evaluate the potential interrelation between vitamin D levels, oxidative stress, and apoptosis, based on liver fibrosis in geriatric patients infected with hepatitis C virus (HCV) genotype 4. Subjects and methods: A total of 120 adult individuals aged 30–68 years were recruited in this study. Of these, 20 healthy subjects (15 men and five women) with a mean age of 48.3±6.1 years were selected as controls, and 100 patients with a mean age of 47.8±4.9 years with chronic HCV (CHC) who had undergone liver biopsy (80 men and 20 women) were included in this study. Based on liver radiographic (computed tomography, magnetic resonance imaging) and histological Metavir system analyses, the CHC patients were classified into three groups: asymptomatic CHC carriers (n=30), fibrosis (n=25), and cirrhosis (n=45). HCV RNA, HCV genotypes, inflammatory cytokines AFP and TNFα, 25-hydroxyvitamin D (25[OH]D) levels, apoptotic markers single-stranded DNA (ssDNA) and soluble Fas (sFas), and oxidative stress markers nitric ... Article in Journal/Newspaper sami Dove Medical Press Clinical Interventions in Aging 523 |
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Clinical Interventions in Aging Gabr,Sami Alghadir,Ahmad Allam,Ahmed Ajarem,Jamaan Al-Basher,Ghada Abdel-Maksoud,Mostafa Ghfar,Ayman Aboud,Alaa Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4 |
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Clinical Interventions in Aging |
description |
Sami A Gabr,1,2 Ahmad H Alghadir,1 Ahmed A Allam,3,4 Jamaan Ajarem,3 Ghada Al-Basher,3 Mostafa A Abdel-Maksoud,3 Ayman A Ghfar,5 Alaa Aboud6 1Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; 4Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt; 5Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 6Internal Endemic Medicine Department, College of Medicine, Beni-Suef University, Beni Suef, Egypt Background: Vitamin D levels play a pivotal role in most biological processes and differ according to age. A deficiency of vitamin D in chronic hepatitis C (CHC) patients has been shown to be linked with the severity of liver fibrosis, but little is known about the mechanism of this association. Objective: In this study, we evaluate the potential interrelation between vitamin D levels, oxidative stress, and apoptosis, based on liver fibrosis in geriatric patients infected with hepatitis C virus (HCV) genotype 4. Subjects and methods: A total of 120 adult individuals aged 30–68 years were recruited in this study. Of these, 20 healthy subjects (15 men and five women) with a mean age of 48.3±6.1 years were selected as controls, and 100 patients with a mean age of 47.8±4.9 years with chronic HCV (CHC) who had undergone liver biopsy (80 men and 20 women) were included in this study. Based on liver radiographic (computed tomography, magnetic resonance imaging) and histological Metavir system analyses, the CHC patients were classified into three groups: asymptomatic CHC carriers (n=30), fibrosis (n=25), and cirrhosis (n=45). HCV RNA, HCV genotypes, inflammatory cytokines AFP and TNFα, 25-hydroxyvitamin D (25[OH]D) levels, apoptotic markers single-stranded DNA (ssDNA) and soluble Fas (sFas), and oxidative stress markers nitric ... |
format |
Article in Journal/Newspaper |
author |
Gabr,Sami Alghadir,Ahmad Allam,Ahmed Ajarem,Jamaan Al-Basher,Ghada Abdel-Maksoud,Mostafa Ghfar,Ayman Aboud,Alaa |
author_facet |
Gabr,Sami Alghadir,Ahmad Allam,Ahmed Ajarem,Jamaan Al-Basher,Ghada Abdel-Maksoud,Mostafa Ghfar,Ayman Aboud,Alaa |
author_sort |
Gabr,Sami |
title |
Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4 |
title_short |
Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4 |
title_full |
Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4 |
title_fullStr |
Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4 |
title_full_unstemmed |
Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4 |
title_sort |
correlation between vitamin d levels and apoptosis in geriatric patients infected with hepatitis c virus genotype 4 |
publisher |
Dove Press |
publishDate |
2016 |
url |
https://www.dovepress.com/correlation-between-vitamin-d-levels-and-apoptosis-in-geriatric-patien-peer-reviewed-fulltext-article-CIA |
genre |
sami |
genre_facet |
sami |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/CIA.S104599 https://www.dovepress.com/correlation-between-vitamin-d-levels-and-apoptosis-in-geriatric-patien-peer-reviewed-fulltext-article-CIA |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/CIA.S104599 |
container_title |
Clinical Interventions in Aging |
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523 |
_version_ |
1766185962177560576 |