Compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a MRI study
Sami Soljanlahti1, Taina Autti1, Laura Hyttinen2, Alpo F Vuorio3, Pekka Keto1, Kirsi Lauerma11Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland; 2Department of Internal Medicine, North Karelia Central Hospital, Joensuu, Finland; 3Division of Internal Medicine,...
Published in: | Vascular Health and Risk Management |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Dove Press
2008
|
Subjects: | |
Online Access: | https://www.dovepress.com/compliance-of-the-aorta-in-two-diseases-affecting-vascular-elasticity--peer-reviewed-fulltext-article-VHRM |
id |
ftdovepress:oai:dovepress.com/1965 |
---|---|
record_format |
openpolar |
spelling |
ftdovepress:oai:dovepress.com/1965 2023-05-15T17:00:12+02:00 Compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a MRI study Soljanlahti,Sami Autti,Taina Hyttinen,Laura Vuorio,Alpo F Keto,Pekka Lauerma,Kirsi 2008-10-10 text/html https://www.dovepress.com/compliance-of-the-aorta-in-two-diseases-affecting-vascular-elasticity--peer-reviewed-fulltext-article-VHRM en eng Dove Press info:eu-repo/semantics/altIdentifier/doi/10.2147/VHRM.S3198 https://www.dovepress.com/compliance-of-the-aorta-in-two-diseases-affecting-vascular-elasticity--peer-reviewed-fulltext-article-VHRM info:eu-repo/semantics/openAccess Vascular Health and Risk Management Original Research info:eu-repo/semantics/article 2008 ftdovepress https://doi.org/10.2147/VHRM.S3198 2022-12-27T21:17:25Z Sami Soljanlahti1, Taina Autti1, Laura Hyttinen2, Alpo F Vuorio3, Pekka Keto1, Kirsi Lauerma11Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland; 2Department of Internal Medicine, North Karelia Central Hospital, Joensuu, Finland; 3Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, FinlandAbstract: Arterial elasticity changes in familial hypercholesterolemia (FH) and diabetes mellitus (DM) with different but overlapping mechanisms. We compared aortic elasticity between 19 FH patients with the same mutation, 18 type 2 DM patients, and 30 controls, all aged 48 to 64. They underwent aortic magnetic resonance imaging, risk-factor assessment, and carotid and femoral ultrasound measurements. All patients were on adequate cardiovascular medication including statins and had established coronary heart disease (CHD). FH patients had longer-duration CHD (13.3 ± 7.7 years) than did DM patients (5.0 ± 3.1). Aortic compliance in the descending thoracic (DM 0.38 ± 0.14 vs control 0.53 ± 0.19, P = 0.032) and abdominal aorta (DM 0.45 ± 0.20 vs control 0.66 ± 0.25, P = 0.011) was lower in DM patients than in controls, whereas no significant difference existed between FH patients and controls. Carotid and femoral intima-media thickness was greater in FH and DM patients than in controls with no difference between patient groups. Carotid or femoral plaques appeared in 15 (79%) FH and in 10 (56%) DM patients. One control had a femoral plaque. Five FH patients showed stenosis, occlusion or both in carotid arteries. In our opinion, DM patients’ lower compliance reflect mainly arterial media affecting arteriosclerosis, while FH patients’ plaque status and longer duration of CHD suggest more advanced atherosclerosis. The FH patients may therefore be at increased risk for atherothrombotic events. However, due to small patient material, larger confirmatory studies are needed.Keywords: MRI, ultrasound, familial hypercholesterolemia, diabetes mellitus, elasticity, ... Article in Journal/Newspaper karelia* sami Dove Medical Press Pekka ENVELOPE(23.816,23.816,66.180,66.180) Vascular Health and Risk Management Volume 4 1103 1109 |
institution |
Open Polar |
collection |
Dove Medical Press |
op_collection_id |
ftdovepress |
language |
English |
topic |
Vascular Health and Risk Management |
spellingShingle |
Vascular Health and Risk Management Soljanlahti,Sami Autti,Taina Hyttinen,Laura Vuorio,Alpo F Keto,Pekka Lauerma,Kirsi Compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a MRI study |
topic_facet |
Vascular Health and Risk Management |
description |
Sami Soljanlahti1, Taina Autti1, Laura Hyttinen2, Alpo F Vuorio3, Pekka Keto1, Kirsi Lauerma11Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland; 2Department of Internal Medicine, North Karelia Central Hospital, Joensuu, Finland; 3Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, FinlandAbstract: Arterial elasticity changes in familial hypercholesterolemia (FH) and diabetes mellitus (DM) with different but overlapping mechanisms. We compared aortic elasticity between 19 FH patients with the same mutation, 18 type 2 DM patients, and 30 controls, all aged 48 to 64. They underwent aortic magnetic resonance imaging, risk-factor assessment, and carotid and femoral ultrasound measurements. All patients were on adequate cardiovascular medication including statins and had established coronary heart disease (CHD). FH patients had longer-duration CHD (13.3 ± 7.7 years) than did DM patients (5.0 ± 3.1). Aortic compliance in the descending thoracic (DM 0.38 ± 0.14 vs control 0.53 ± 0.19, P = 0.032) and abdominal aorta (DM 0.45 ± 0.20 vs control 0.66 ± 0.25, P = 0.011) was lower in DM patients than in controls, whereas no significant difference existed between FH patients and controls. Carotid and femoral intima-media thickness was greater in FH and DM patients than in controls with no difference between patient groups. Carotid or femoral plaques appeared in 15 (79%) FH and in 10 (56%) DM patients. One control had a femoral plaque. Five FH patients showed stenosis, occlusion or both in carotid arteries. In our opinion, DM patients’ lower compliance reflect mainly arterial media affecting arteriosclerosis, while FH patients’ plaque status and longer duration of CHD suggest more advanced atherosclerosis. The FH patients may therefore be at increased risk for atherothrombotic events. However, due to small patient material, larger confirmatory studies are needed.Keywords: MRI, ultrasound, familial hypercholesterolemia, diabetes mellitus, elasticity, ... |
format |
Article in Journal/Newspaper |
author |
Soljanlahti,Sami Autti,Taina Hyttinen,Laura Vuorio,Alpo F Keto,Pekka Lauerma,Kirsi |
author_facet |
Soljanlahti,Sami Autti,Taina Hyttinen,Laura Vuorio,Alpo F Keto,Pekka Lauerma,Kirsi |
author_sort |
Soljanlahti,Sami |
title |
Compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a MRI study |
title_short |
Compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a MRI study |
title_full |
Compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a MRI study |
title_fullStr |
Compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a MRI study |
title_full_unstemmed |
Compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a MRI study |
title_sort |
compliance of the aorta in two diseases affecting vascular elasticity, familial hypercholesterolemia and diabetes: a mri study |
publisher |
Dove Press |
publishDate |
2008 |
url |
https://www.dovepress.com/compliance-of-the-aorta-in-two-diseases-affecting-vascular-elasticity--peer-reviewed-fulltext-article-VHRM |
long_lat |
ENVELOPE(23.816,23.816,66.180,66.180) |
geographic |
Pekka |
geographic_facet |
Pekka |
genre |
karelia* sami |
genre_facet |
karelia* sami |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.2147/VHRM.S3198 https://www.dovepress.com/compliance-of-the-aorta-in-two-diseases-affecting-vascular-elasticity--peer-reviewed-fulltext-article-VHRM |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/VHRM.S3198 |
container_title |
Vascular Health and Risk Management |
container_volume |
Volume 4 |
container_start_page |
1103 |
op_container_end_page |
1109 |
_version_ |
1766052830171365376 |