The investigation of primary physicochemical and pharmaco-biological properties of polynuclear iron(III) complexes with dextran and its derivatives

• Published in: Chemical Industry and Chemical Engineering Quarterly
• Main Authors: Cvetković Dragan M., Nikolić Vesna D., Nikolić Ljubiša B.
• Format: Other/Unknown Material
• Language: unknown
• Published: 2005
• Subjects: polynuclear iron complexes; low molecular dextran; hydrogenated low molecular dextran; dextran carbonic acid; Carbonic acid
• Online Access: https://doi.org/10.2298/CICEQ0501030C

The results of the investigations of primary physicochemical and pharmaco-biological properties of polynuclear iron(III) complexes with low molecular dextran (LMD), hydrogenated low molecular dextran (H-LMD) and dextran carbonic acid (DCA) are presented. The investigations included the complex resistance to hydrolytic decomposition in highly acidic medium, the (TFH-A)-value, and neutral medium at 120oC, the (TFH-120)-value, the viscosity of the parenteral solutions, iron(III) resorption dynamics to serum after the i.m. and i.v. application of the preparation to rabbits, the acute toxicity (LD50) in mice, and the residual iron(III) quantity at the i.m. application site. Iron(III) complexes with dextran carbonic acid (DCA) appeared to be the most suitable for use in veterinary and human medicine.