Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012.
INTRODUCTION:Human angiostrongyliasis (HA) is a neurological helminthic disease caused by the lung worm Angiostrongylus cantonensis. It is suspected in the combination of travel or a residence in an endemic area and eosinophilic meningitis. In Mayotte, an island in the Indian Ocean, cases are rare b...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0004635 https://doaj.org/article/fff480b6e0b04b2389fbfa529b971382 |
id |
ftdoajarticles:oai:doaj.org/article:fff480b6e0b04b2389fbfa529b971382 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:fff480b6e0b04b2389fbfa529b971382 2023-05-15T15:16:09+02:00 Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012. Loïc Epelboin Renaud Blondé Abdourahim Chamouine Alexandra Chrisment Laure Diancourt Nicolas Villemant Agnès Atale Claire Cadix Valérie Caro Denis Malvy Louis Collet 2016-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004635 https://doaj.org/article/fff480b6e0b04b2389fbfa529b971382 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4856411?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004635 https://doaj.org/article/fff480b6e0b04b2389fbfa529b971382 PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004635 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004635 2022-12-31T01:15:53Z INTRODUCTION:Human angiostrongyliasis (HA) is a neurological helminthic disease caused by the lung worm Angiostrongylus cantonensis. It is suspected in the combination of travel or a residence in an endemic area and eosinophilic meningitis. In Mayotte, an island in the Indian Ocean, cases are rare but regular. The main objective of our study was to describe the epidemiological and diagnosis clues of HA in Mayotte. The secondary objectives were to evaluate the contribution of Real-Time Polymerase Chain Reaction (RT- PCR) for the diagnosis of HA, delineate the characteristics of the local transmission and ascertain the presence of A. cantonensis in Achatina fulica, the potential vector of the disease. MATERIALS AND METHODS:Between 2007 and 2012, all cases of eosinophilic meningitis were retrospectively included and investigated by RT- PCR in the CSF. Descriptive analysis was conducted for clinical, biological and radiological features, and were analyzed for all patients together with the search for prognostic factors for mortality. Concurrently, geolocalization and temporal parameters were studied to correlate the occurrence of the cases with rainfall seasons and snails were collected to enhance a parasitic carriage with real time PCR. RESULTS:During the 6-year period of the study, 14 cases were identified (2.3 cases/year) and 9 among 10 remaining CSF were positive in PCR. Among 14 cases of EM, 13 were less than 2 year-old children. The 1 year mortality rate was 5/14 (35.7%). Among survivors, 3/7 (42.8%) presented neurological sequelae. Factors associated with mortality were dysfunction of cranial nerves, abnormal brain imaging, and CSF glucose level inferior to 2 mmol/l. Occurrence of cases was temporarily and spatially correlated to the rainy season. Among the 64 collected giant snails, 6 (9.4%) were positive with A. cantonensis PCR. The likely main route of transmission was the children licking snails, carriers of the parasite. CONCLUSION:In Mayotte, HA was mainly found in paediatric cases under 2 years old, ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian PLOS Neglected Tropical Diseases 10 5 e0004635 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Loïc Epelboin Renaud Blondé Abdourahim Chamouine Alexandra Chrisment Laure Diancourt Nicolas Villemant Agnès Atale Claire Cadix Valérie Caro Denis Malvy Louis Collet Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
INTRODUCTION:Human angiostrongyliasis (HA) is a neurological helminthic disease caused by the lung worm Angiostrongylus cantonensis. It is suspected in the combination of travel or a residence in an endemic area and eosinophilic meningitis. In Mayotte, an island in the Indian Ocean, cases are rare but regular. The main objective of our study was to describe the epidemiological and diagnosis clues of HA in Mayotte. The secondary objectives were to evaluate the contribution of Real-Time Polymerase Chain Reaction (RT- PCR) for the diagnosis of HA, delineate the characteristics of the local transmission and ascertain the presence of A. cantonensis in Achatina fulica, the potential vector of the disease. MATERIALS AND METHODS:Between 2007 and 2012, all cases of eosinophilic meningitis were retrospectively included and investigated by RT- PCR in the CSF. Descriptive analysis was conducted for clinical, biological and radiological features, and were analyzed for all patients together with the search for prognostic factors for mortality. Concurrently, geolocalization and temporal parameters were studied to correlate the occurrence of the cases with rainfall seasons and snails were collected to enhance a parasitic carriage with real time PCR. RESULTS:During the 6-year period of the study, 14 cases were identified (2.3 cases/year) and 9 among 10 remaining CSF were positive in PCR. Among 14 cases of EM, 13 were less than 2 year-old children. The 1 year mortality rate was 5/14 (35.7%). Among survivors, 3/7 (42.8%) presented neurological sequelae. Factors associated with mortality were dysfunction of cranial nerves, abnormal brain imaging, and CSF glucose level inferior to 2 mmol/l. Occurrence of cases was temporarily and spatially correlated to the rainy season. Among the 64 collected giant snails, 6 (9.4%) were positive with A. cantonensis PCR. The likely main route of transmission was the children licking snails, carriers of the parasite. CONCLUSION:In Mayotte, HA was mainly found in paediatric cases under 2 years old, ... |
format |
Article in Journal/Newspaper |
author |
Loïc Epelboin Renaud Blondé Abdourahim Chamouine Alexandra Chrisment Laure Diancourt Nicolas Villemant Agnès Atale Claire Cadix Valérie Caro Denis Malvy Louis Collet |
author_facet |
Loïc Epelboin Renaud Blondé Abdourahim Chamouine Alexandra Chrisment Laure Diancourt Nicolas Villemant Agnès Atale Claire Cadix Valérie Caro Denis Malvy Louis Collet |
author_sort |
Loïc Epelboin |
title |
Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012. |
title_short |
Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012. |
title_full |
Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012. |
title_fullStr |
Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012. |
title_full_unstemmed |
Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012. |
title_sort |
angiostrongylus cantonensis infection on mayotte island, indian ocean, 2007-2012. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004635 https://doaj.org/article/fff480b6e0b04b2389fbfa529b971382 |
geographic |
Arctic Indian |
geographic_facet |
Arctic Indian |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004635 (2016) |
op_relation |
http://europepmc.org/articles/PMC4856411?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004635 https://doaj.org/article/fff480b6e0b04b2389fbfa529b971382 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004635 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
5 |
container_start_page |
e0004635 |
_version_ |
1766346454161424384 |