The FTO, PNPLA3 and TM6SF2 Gene Polymorphisms and Genetic Predisposition to NAFLD in Yakut Population

• Published in: International Journal of Biomedicine
• Main Authors: Aleksandra T. Diakonova, Khariton A. Kurtanov, Nadezhda I. Pavlova, Tuyara N. Aleksandrova
• Format: Article in Journal/Newspaper
• Language: English
• Published: International Medical Research and Development Corporation 2021
• Subjects: nonalcoholic fatty liver disease; single nucleotide polymorphism; genome-wide association study; yakuts; Medicine; R; Yakuts
• Online Access: https://doi.org/10.21103/Article11(1)_OA16; https://doaj.org/article/ff635293da874b60a984145937f1b7be

The aim of our research was to study the distribution of alleles and genotypes of the FTO rs9939609 SNP, the PNPLA3 rs738409 SNP, and the TM6SF2 rs58542926 SNP in the Yakut population. Methods and Results: A total of 85 DNA samples from the population were tested. An analysis of the frequency distribution of alleles and genotypes of the FTO rs9939609 SNP in the study group did not reveal significant differences. An analysis of the frequency distribution of alleles and genotypes of the PNPLA3 rs738409 SNP revealed that in men and women the G allele and the homozygous GG genotype prevailed. The results of the analysis of the frequency distribution of alleles and genotypes of the TM6SF2 rs58542926 SNP showed the predominance of individuals with the C allele (89% in men and 90% in women) with statistical significance in women. Conclusion: The further studies with a larger sample size are required to detect the features of the distribution of alleles and genotypes of the FTO rs9939609 SNP and the TM6SF2 rs58542926 SNP in that population.