Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach
The genome sequence of the human malaria parasite, Plasmodium falciparum, was released almost a decade ago. A majority of the Plasmodium genome, however, remains annotated to code for hypothetical proteins with unknown functions. The introduction of forward genetics has provided novel means to gain...
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ftdoajarticles:oai:doaj.org/article:ff52873ecac84f31a80e66c29a7e4fd1 2024-09-09T19:24:21+00:00 Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach Bharath Balu 2012-01-01T00:00:00Z https://doi.org/10.1155/2012/829210 https://doaj.org/article/ff52873ecac84f31a80e66c29a7e4fd1 EN eng Wiley http://dx.doi.org/10.1155/2012/829210 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/829210 https://doaj.org/article/ff52873ecac84f31a80e66c29a7e4fd1 Journal of Tropical Medicine, Vol 2012 (2012) Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1155/2012/829210 2024-08-05T17:48:40Z The genome sequence of the human malaria parasite, Plasmodium falciparum, was released almost a decade ago. A majority of the Plasmodium genome, however, remains annotated to code for hypothetical proteins with unknown functions. The introduction of forward genetics has provided novel means to gain a better understanding of gene functions and their associated phenotypes in Plasmodium. Even with certain limitations, the technique has already shown significant promise to increase our understanding of parasite biology needed for rationalized drug and vaccine design. Further improvements to the mutagenesis technique and the design of novel genetic screens should lead us to some exciting discoveries about the critical weaknesses of Plasmodium, and greatly aid in the development of new disease intervention strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2012 1 7 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Bharath Balu Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
The genome sequence of the human malaria parasite, Plasmodium falciparum, was released almost a decade ago. A majority of the Plasmodium genome, however, remains annotated to code for hypothetical proteins with unknown functions. The introduction of forward genetics has provided novel means to gain a better understanding of gene functions and their associated phenotypes in Plasmodium. Even with certain limitations, the technique has already shown significant promise to increase our understanding of parasite biology needed for rationalized drug and vaccine design. Further improvements to the mutagenesis technique and the design of novel genetic screens should lead us to some exciting discoveries about the critical weaknesses of Plasmodium, and greatly aid in the development of new disease intervention strategies. |
format |
Article in Journal/Newspaper |
author |
Bharath Balu |
author_facet |
Bharath Balu |
author_sort |
Bharath Balu |
title |
Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach |
title_short |
Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach |
title_full |
Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach |
title_fullStr |
Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach |
title_full_unstemmed |
Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach |
title_sort |
moving “forward” in plasmodium genetics through a transposon-based approach |
publisher |
Wiley |
publishDate |
2012 |
url |
https://doi.org/10.1155/2012/829210 https://doaj.org/article/ff52873ecac84f31a80e66c29a7e4fd1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2012 (2012) |
op_relation |
http://dx.doi.org/10.1155/2012/829210 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/829210 https://doaj.org/article/ff52873ecac84f31a80e66c29a7e4fd1 |
op_doi |
https://doi.org/10.1155/2012/829210 |
container_title |
Journal of Tropical Medicine |
container_volume |
2012 |
container_start_page |
1 |
op_container_end_page |
7 |
_version_ |
1809894258271846400 |