Effects of Pharmacists’ Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia—A Secondary Analysis of a Randomized Controlled Trial
Age-associated physiological changes and extensive drug treatment including use of potentially inappropriate medications (PIMs) pose a significant risk of drug–drug interactions and adverse drug events among elderly people with dementia. This study aimed at analysing the effects of clinical pharmaci...
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ftdoajarticles:oai:doaj.org/article:ff4cc8412c0a427d8e718d4c079c1d15 2023-05-15T17:44:53+02:00 Effects of Pharmacists’ Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia—A Secondary Analysis of a Randomized Controlled Trial Maria Gustafsson Maria Sjölander Bettina Pfister Jörn Schneede Hugo Lövheim 2018-01-01T00:00:00Z https://doi.org/10.3390/pharmacy6010007 https://doaj.org/article/ff4cc8412c0a427d8e718d4c079c1d15 EN eng MDPI AG http://www.mdpi.com/2226-4787/6/1/7 https://doaj.org/toc/2226-4787 2226-4787 doi:10.3390/pharmacy6010007 https://doaj.org/article/ff4cc8412c0a427d8e718d4c079c1d15 Pharmacy, Vol 6, Iss 1, p 7 (2018) medication reviews potentially inappropriate medications drug-related readmissions dementia Pharmacy and materia medica RS1-441 article 2018 ftdoajarticles https://doi.org/10.3390/pharmacy6010007 2022-12-30T23:37:29Z Age-associated physiological changes and extensive drug treatment including use of potentially inappropriate medications (PIMs) pose a significant risk of drug–drug interactions and adverse drug events among elderly people with dementia. This study aimed at analysing the effects of clinical pharmacists’ interventions on use of PIMs, risk of emergency department visits, and time to institutionalization. Furthermore, a descriptive analysis was conducted of circumstances associated with drug-related readmissions. This is a secondary analysis of data from a randomized controlled intervention study conducted in two hospitals in Northern Sweden. The study included patients (n = 460) 65 years or older with dementia or cognitive impairment. The intervention consisted of comprehensive medication reviews conducted by clinical pharmacists as part of a healthcare team. There was a larger decrease in PIMs in the intervention group compared with the control group (p = 0.011). No significant difference was found in time to first all-cause emergency department visits (HR = 0.994, 95% CI = 0.755–1.307 p = 0.963, simple Cox regression) or time to institutionalization (HR = 0.761, 95% CI = 0.409–1.416 p = 0.389, simple Cox regression) within 180 days. Common reasons for drug-related readmissions were negative effects of sedatives, opioids, antidepressants, and anticholinergic agents, resulting in confusion, falling, and sedation. Drug-related readmissions were associated with living at home, heart failure, and diabetes. Pharmacist-provided interventions were able to reduce PIMs among elderly people with dementia and cognitive impairment. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles Pharmacy 6 1 7 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
medication reviews potentially inappropriate medications drug-related readmissions dementia Pharmacy and materia medica RS1-441 |
spellingShingle |
medication reviews potentially inappropriate medications drug-related readmissions dementia Pharmacy and materia medica RS1-441 Maria Gustafsson Maria Sjölander Bettina Pfister Jörn Schneede Hugo Lövheim Effects of Pharmacists’ Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia—A Secondary Analysis of a Randomized Controlled Trial |
topic_facet |
medication reviews potentially inappropriate medications drug-related readmissions dementia Pharmacy and materia medica RS1-441 |
description |
Age-associated physiological changes and extensive drug treatment including use of potentially inappropriate medications (PIMs) pose a significant risk of drug–drug interactions and adverse drug events among elderly people with dementia. This study aimed at analysing the effects of clinical pharmacists’ interventions on use of PIMs, risk of emergency department visits, and time to institutionalization. Furthermore, a descriptive analysis was conducted of circumstances associated with drug-related readmissions. This is a secondary analysis of data from a randomized controlled intervention study conducted in two hospitals in Northern Sweden. The study included patients (n = 460) 65 years or older with dementia or cognitive impairment. The intervention consisted of comprehensive medication reviews conducted by clinical pharmacists as part of a healthcare team. There was a larger decrease in PIMs in the intervention group compared with the control group (p = 0.011). No significant difference was found in time to first all-cause emergency department visits (HR = 0.994, 95% CI = 0.755–1.307 p = 0.963, simple Cox regression) or time to institutionalization (HR = 0.761, 95% CI = 0.409–1.416 p = 0.389, simple Cox regression) within 180 days. Common reasons for drug-related readmissions were negative effects of sedatives, opioids, antidepressants, and anticholinergic agents, resulting in confusion, falling, and sedation. Drug-related readmissions were associated with living at home, heart failure, and diabetes. Pharmacist-provided interventions were able to reduce PIMs among elderly people with dementia and cognitive impairment. |
format |
Article in Journal/Newspaper |
author |
Maria Gustafsson Maria Sjölander Bettina Pfister Jörn Schneede Hugo Lövheim |
author_facet |
Maria Gustafsson Maria Sjölander Bettina Pfister Jörn Schneede Hugo Lövheim |
author_sort |
Maria Gustafsson |
title |
Effects of Pharmacists’ Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia—A Secondary Analysis of a Randomized Controlled Trial |
title_short |
Effects of Pharmacists’ Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia—A Secondary Analysis of a Randomized Controlled Trial |
title_full |
Effects of Pharmacists’ Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia—A Secondary Analysis of a Randomized Controlled Trial |
title_fullStr |
Effects of Pharmacists’ Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia—A Secondary Analysis of a Randomized Controlled Trial |
title_full_unstemmed |
Effects of Pharmacists’ Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia—A Secondary Analysis of a Randomized Controlled Trial |
title_sort |
effects of pharmacists’ interventions on inappropriate drug use and drug-related readmissions in people with dementia—a secondary analysis of a randomized controlled trial |
publisher |
MDPI AG |
publishDate |
2018 |
url |
https://doi.org/10.3390/pharmacy6010007 https://doaj.org/article/ff4cc8412c0a427d8e718d4c079c1d15 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Pharmacy, Vol 6, Iss 1, p 7 (2018) |
op_relation |
http://www.mdpi.com/2226-4787/6/1/7 https://doaj.org/toc/2226-4787 2226-4787 doi:10.3390/pharmacy6010007 https://doaj.org/article/ff4cc8412c0a427d8e718d4c079c1d15 |
op_doi |
https://doi.org/10.3390/pharmacy6010007 |
container_title |
Pharmacy |
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6 |
container_issue |
1 |
container_start_page |
7 |
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