Ivermectin and malaria control
Abstract As the world begins to realize the very real prospect of eliminating malaria as a public health problem globally, the scientific community is acutely aware that novel and innovative new tools will be required if that lofty goal is to be accomplished. Moreover, the need for comprehensive, in...
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ftdoajarticles:oai:doaj.org/article:ff40985e48264f6892590c8d54114d0d 2023-05-15T15:16:29+02:00 Ivermectin and malaria control Satoshi Ōmura Andy Crump 2017-04-01T00:00:00Z https://doi.org/10.1186/s12936-017-1825-9 https://doaj.org/article/ff40985e48264f6892590c8d54114d0d EN eng BMC http://link.springer.com/article/10.1186/s12936-017-1825-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1825-9 1475-2875 https://doaj.org/article/ff40985e48264f6892590c8d54114d0d Malaria Journal, Vol 16, Iss 1, Pp 1-3 (2017) Ivermectin Malaria Feed-through insecticide Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-1825-9 2022-12-30T21:59:28Z Abstract As the world begins to realize the very real prospect of eliminating malaria as a public health problem globally, the scientific community is acutely aware that novel and innovative new tools will be required if that lofty goal is to be accomplished. Moreover, the need for comprehensive, integrated products and interventions is being recognized in order for the critical ‘final steps’ toward elimination to be taken successfully. Failure to take these crucial last steps have dogged all past global disease elimination programmes, except for smallpox. The success of ivermectin in driving two of the most devastating and disfiguring neglected tropical diseases (NTD) to the brink of elimination has been well documented. The drug also bestows immeasurable non-target benefits, increasing the health and socioeconomic prospects of all communities where mass drug administration (MDA) has been carried out. Ivermectin kills a variety of parasites and insects, including the Anopheline vectors of malaria parasites. In view of long-standing MDA programmes, increasing attention is now being paid to the potential offered by re-formulating and re-purposing ivermectin to function as a feed-though mosquitocidal tool. This will provide a comprehensively beneficial weapon, for the anti-malarial armamentarium, as well as for probably improving the impact on existing target diseases. Prospects currently look highly promising, especially as the drug is already proven to be extremely safe for human use. However, for maximum impact, detailed analysis of various analogues of the unique ivermectin, as well as the parent avermectin compounds, will need to be undertaken. ‘Ivermectin’ comprises an imprecise mix of two compounds, both of which are potent anthelmintics. Yet recently, it has been confirmed that only the minor of the two component compounds is molluscicidal. Further structure activity relationship studies may well identify the analogue, analogues or combination thereof best suited for use in a concerted initiative to ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
institution |
Open Polar |
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op_collection_id |
ftdoajarticles |
language |
English |
topic |
Ivermectin Malaria Feed-through insecticide Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Ivermectin Malaria Feed-through insecticide Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Satoshi Ōmura Andy Crump Ivermectin and malaria control |
topic_facet |
Ivermectin Malaria Feed-through insecticide Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract As the world begins to realize the very real prospect of eliminating malaria as a public health problem globally, the scientific community is acutely aware that novel and innovative new tools will be required if that lofty goal is to be accomplished. Moreover, the need for comprehensive, integrated products and interventions is being recognized in order for the critical ‘final steps’ toward elimination to be taken successfully. Failure to take these crucial last steps have dogged all past global disease elimination programmes, except for smallpox. The success of ivermectin in driving two of the most devastating and disfiguring neglected tropical diseases (NTD) to the brink of elimination has been well documented. The drug also bestows immeasurable non-target benefits, increasing the health and socioeconomic prospects of all communities where mass drug administration (MDA) has been carried out. Ivermectin kills a variety of parasites and insects, including the Anopheline vectors of malaria parasites. In view of long-standing MDA programmes, increasing attention is now being paid to the potential offered by re-formulating and re-purposing ivermectin to function as a feed-though mosquitocidal tool. This will provide a comprehensively beneficial weapon, for the anti-malarial armamentarium, as well as for probably improving the impact on existing target diseases. Prospects currently look highly promising, especially as the drug is already proven to be extremely safe for human use. However, for maximum impact, detailed analysis of various analogues of the unique ivermectin, as well as the parent avermectin compounds, will need to be undertaken. ‘Ivermectin’ comprises an imprecise mix of two compounds, both of which are potent anthelmintics. Yet recently, it has been confirmed that only the minor of the two component compounds is molluscicidal. Further structure activity relationship studies may well identify the analogue, analogues or combination thereof best suited for use in a concerted initiative to ... |
format |
Article in Journal/Newspaper |
author |
Satoshi Ōmura Andy Crump |
author_facet |
Satoshi Ōmura Andy Crump |
author_sort |
Satoshi Ōmura |
title |
Ivermectin and malaria control |
title_short |
Ivermectin and malaria control |
title_full |
Ivermectin and malaria control |
title_fullStr |
Ivermectin and malaria control |
title_full_unstemmed |
Ivermectin and malaria control |
title_sort |
ivermectin and malaria control |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-1825-9 https://doaj.org/article/ff40985e48264f6892590c8d54114d0d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-3 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-1825-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1825-9 1475-2875 https://doaj.org/article/ff40985e48264f6892590c8d54114d0d |
op_doi |
https://doi.org/10.1186/s12936-017-1825-9 |
container_title |
Malaria Journal |
container_volume |
16 |
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1 |
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1766346785597423616 |