Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control
Abstract Background The optimal heart rate (HR) in dogs with atrial fibrillation (AF) is unknown. Impact of HR on survival needs elucidation. Hypothesis/Objectives Dogs with a 24 hours Holter‐derived meanHR ≤125 beats per minute (bpm; rate controlled) survive longer than dogs with higher meanHR. We...
Published in: | Journal of Veterinary Internal Medicine |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1111/jvim.16666 https://doaj.org/article/ff35f4a0d0cf466c933b45ad1c468025 |
id |
ftdoajarticles:oai:doaj.org/article:ff35f4a0d0cf466c933b45ad1c468025 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:ff35f4a0d0cf466c933b45ad1c468025 2023-06-18T03:42:35+02:00 Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control Brigite Pedro Antonia Mavropoulou Mark A. Oyama Christopher Linney João Neves Joanna Dukes‐McEwan Ana P. Fontes‐Sousa Anna R. Gelzer 2023-05-01T00:00:00Z https://doi.org/10.1111/jvim.16666 https://doaj.org/article/ff35f4a0d0cf466c933b45ad1c468025 EN eng Wiley https://doi.org/10.1111/jvim.16666 https://doaj.org/toc/0891-6640 https://doaj.org/toc/1939-1676 1939-1676 0891-6640 doi:10.1111/jvim.16666 https://doaj.org/article/ff35f4a0d0cf466c933b45ad1c468025 Journal of Veterinary Internal Medicine, Vol 37, Iss 3, Pp 887-899 (2023) arrhythmia biomarkers echocardiography Holter survival Veterinary medicine SF600-1100 article 2023 ftdoajarticles https://doi.org/10.1111/jvim.16666 2023-06-04T00:37:55Z Abstract Background The optimal heart rate (HR) in dogs with atrial fibrillation (AF) is unknown. Impact of HR on survival needs elucidation. Hypothesis/Objectives Dogs with a 24 hours Holter‐derived meanHR ≤125 beats per minute (bpm; rate controlled) survive longer than dogs with higher meanHR. We further aimed to determine which variables predict ability to achieving rate control. Animals Sixty dogs with AF. Methods Holter‐derived meanHR, clinical, echocardiographic, and biomarker variables were analyzed prospectively. Survival was recorded from time of rate control, with all‐cause mortality as primary endpoint. Cox proportional hazards analysis identified variables independently associated with survival; Kaplan‐Meier survival analysis estimated the median survival time of dogs with meanHR ≤125 bpm vs >125 bpm. Logistic regression explored baseline variables associated with inability to achieve rate control. Results Structural heart disease was present in 56/60 dogs, 50/60 had congestive heart failure, and 45/60 died. Median time to all‐cause death was 160 days (range, 88‐303 days), dogs with meanHR >125 bpm (n = 27) lived 33 days (95% confidence interval [CI], 15‐141 days), dogs with meanHR ≤125 bpm (n = 33) lived 608 days (95% CI, 155‐880 days; P < .0001). Congenital heart disease and N‐terminal pro‐B‐type natriuretic peptide were independently associated with higher risk of death (P < .01 and <.0001, respectively) whereas meanHR ≤125 bpm decreased the risk of death (P < .001). Increased left atrial size, increased C‐reactive protein concentration and lower blood pressure at admission were associated with failure to achieve rate control. Conclusions and Clinical Importance Rate control affects survival; an optimal target meanHR <125 bpm should be sought in dogs with AF. Baseline patient variables can help predict if rate control is achievable. Article in Journal/Newspaper Orca Directory of Open Access Journals: DOAJ Articles Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Journal of Veterinary Internal Medicine 37 3 887 899 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
arrhythmia biomarkers echocardiography Holter survival Veterinary medicine SF600-1100 |
spellingShingle |
arrhythmia biomarkers echocardiography Holter survival Veterinary medicine SF600-1100 Brigite Pedro Antonia Mavropoulou Mark A. Oyama Christopher Linney João Neves Joanna Dukes‐McEwan Ana P. Fontes‐Sousa Anna R. Gelzer Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control |
topic_facet |
arrhythmia biomarkers echocardiography Holter survival Veterinary medicine SF600-1100 |
description |
Abstract Background The optimal heart rate (HR) in dogs with atrial fibrillation (AF) is unknown. Impact of HR on survival needs elucidation. Hypothesis/Objectives Dogs with a 24 hours Holter‐derived meanHR ≤125 beats per minute (bpm; rate controlled) survive longer than dogs with higher meanHR. We further aimed to determine which variables predict ability to achieving rate control. Animals Sixty dogs with AF. Methods Holter‐derived meanHR, clinical, echocardiographic, and biomarker variables were analyzed prospectively. Survival was recorded from time of rate control, with all‐cause mortality as primary endpoint. Cox proportional hazards analysis identified variables independently associated with survival; Kaplan‐Meier survival analysis estimated the median survival time of dogs with meanHR ≤125 bpm vs >125 bpm. Logistic regression explored baseline variables associated with inability to achieve rate control. Results Structural heart disease was present in 56/60 dogs, 50/60 had congestive heart failure, and 45/60 died. Median time to all‐cause death was 160 days (range, 88‐303 days), dogs with meanHR >125 bpm (n = 27) lived 33 days (95% confidence interval [CI], 15‐141 days), dogs with meanHR ≤125 bpm (n = 33) lived 608 days (95% CI, 155‐880 days; P < .0001). Congenital heart disease and N‐terminal pro‐B‐type natriuretic peptide were independently associated with higher risk of death (P < .01 and <.0001, respectively) whereas meanHR ≤125 bpm decreased the risk of death (P < .001). Increased left atrial size, increased C‐reactive protein concentration and lower blood pressure at admission were associated with failure to achieve rate control. Conclusions and Clinical Importance Rate control affects survival; an optimal target meanHR <125 bpm should be sought in dogs with AF. Baseline patient variables can help predict if rate control is achievable. |
format |
Article in Journal/Newspaper |
author |
Brigite Pedro Antonia Mavropoulou Mark A. Oyama Christopher Linney João Neves Joanna Dukes‐McEwan Ana P. Fontes‐Sousa Anna R. Gelzer |
author_facet |
Brigite Pedro Antonia Mavropoulou Mark A. Oyama Christopher Linney João Neves Joanna Dukes‐McEwan Ana P. Fontes‐Sousa Anna R. Gelzer |
author_sort |
Brigite Pedro |
title |
Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control |
title_short |
Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control |
title_full |
Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control |
title_fullStr |
Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control |
title_full_unstemmed |
Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control |
title_sort |
optimal rate control in dogs with atrial fibrillation—orca study—multicenter prospective observational study: prognostic impact and predictors of rate control |
publisher |
Wiley |
publishDate |
2023 |
url |
https://doi.org/10.1111/jvim.16666 https://doaj.org/article/ff35f4a0d0cf466c933b45ad1c468025 |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) |
geographic |
Meier |
geographic_facet |
Meier |
genre |
Orca |
genre_facet |
Orca |
op_source |
Journal of Veterinary Internal Medicine, Vol 37, Iss 3, Pp 887-899 (2023) |
op_relation |
https://doi.org/10.1111/jvim.16666 https://doaj.org/toc/0891-6640 https://doaj.org/toc/1939-1676 1939-1676 0891-6640 doi:10.1111/jvim.16666 https://doaj.org/article/ff35f4a0d0cf466c933b45ad1c468025 |
op_doi |
https://doi.org/10.1111/jvim.16666 |
container_title |
Journal of Veterinary Internal Medicine |
container_volume |
37 |
container_issue |
3 |
container_start_page |
887 |
op_container_end_page |
899 |
_version_ |
1769008574210506752 |