Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam.
Schistosoma japonicum is a major public health concern in the Peoples' Republic of China (PRC), with about 800,000 people infected and another 50 million living in areas at risk of infection. Based on ecological, environmental, population genetic and molecular factors, schistosomiasis transmiss...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0001588 https://doaj.org/article/ff2deb7013564b1a9b501940f762a7c0 |
id |
ftdoajarticles:oai:doaj.org/article:ff2deb7013564b1a9b501940f762a7c0 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:ff2deb7013564b1a9b501940f762a7c0 2023-05-15T15:16:53+02:00 Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam. Darren J Gray Aaron P Thrift Gail M Williams Feng Zheng Yue-Sheng Li Jiagang Guo Honggen Chen Tianping Wang Xin Jiang Xu Rong Zhu Hongqing Zhu Chun Li Cao Dan Dan Lin Zhen Yuan Zhao Robert S Li George M Davis Donald P McManus 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001588 https://doaj.org/article/ff2deb7013564b1a9b501940f762a7c0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3323517?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001588 https://doaj.org/article/ff2deb7013564b1a9b501940f762a7c0 PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1588 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001588 2022-12-31T13:34:20Z Schistosoma japonicum is a major public health concern in the Peoples' Republic of China (PRC), with about 800,000 people infected and another 50 million living in areas at risk of infection. Based on ecological, environmental, population genetic and molecular factors, schistosomiasis transmission in PRC can be categorised into four discrete ecosystems or transmission modes. It is predicted that, long-term, the Three Gorges Dam (TGD) will impact upon the transmission of schistosomiasis in the PRC, with varying degree across the four transmission modes.We undertook longitudinal surveillance from 2002 to 2006 in sentinel villages of the three transmission modes below the TGD across four provinces (Hunan, Jiangxi, Hubei and Anhui) to determine whether there was any immediate impact of the TGD on schistosomiasis transmission. Eight sentinel villages were selected to represent both province and transmission mode. The primary end point measured was human incidence. Here we present the results of this five-year longitudinal cohort study. Results showed that the incidence of human S. japonicum infection declined considerably within individual villages and overall mode over the course of the study. This is also reflected in the yearly odds ratios (adjusted) for infection risk that showed significant (P<0.01) downward trends in all modes over the follow-up period.The decrease in human S. japonicum incidence observed across all transmission modes in this study can probably be attributed to the annual human and bovine PZQ chemotherapy. If an increase in schistosome transmission had occurred as a result of the TGD, it would be of negligible size compared to the treatment induced decline seen here. It appears therefore that there has been virtually no immediate impact of the TGD on schistosomiasis transmission downstream of the dam. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 4 e1588 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Darren J Gray Aaron P Thrift Gail M Williams Feng Zheng Yue-Sheng Li Jiagang Guo Honggen Chen Tianping Wang Xin Jiang Xu Rong Zhu Hongqing Zhu Chun Li Cao Dan Dan Lin Zhen Yuan Zhao Robert S Li George M Davis Donald P McManus Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Schistosoma japonicum is a major public health concern in the Peoples' Republic of China (PRC), with about 800,000 people infected and another 50 million living in areas at risk of infection. Based on ecological, environmental, population genetic and molecular factors, schistosomiasis transmission in PRC can be categorised into four discrete ecosystems or transmission modes. It is predicted that, long-term, the Three Gorges Dam (TGD) will impact upon the transmission of schistosomiasis in the PRC, with varying degree across the four transmission modes.We undertook longitudinal surveillance from 2002 to 2006 in sentinel villages of the three transmission modes below the TGD across four provinces (Hunan, Jiangxi, Hubei and Anhui) to determine whether there was any immediate impact of the TGD on schistosomiasis transmission. Eight sentinel villages were selected to represent both province and transmission mode. The primary end point measured was human incidence. Here we present the results of this five-year longitudinal cohort study. Results showed that the incidence of human S. japonicum infection declined considerably within individual villages and overall mode over the course of the study. This is also reflected in the yearly odds ratios (adjusted) for infection risk that showed significant (P<0.01) downward trends in all modes over the follow-up period.The decrease in human S. japonicum incidence observed across all transmission modes in this study can probably be attributed to the annual human and bovine PZQ chemotherapy. If an increase in schistosome transmission had occurred as a result of the TGD, it would be of negligible size compared to the treatment induced decline seen here. It appears therefore that there has been virtually no immediate impact of the TGD on schistosomiasis transmission downstream of the dam. |
format |
Article in Journal/Newspaper |
author |
Darren J Gray Aaron P Thrift Gail M Williams Feng Zheng Yue-Sheng Li Jiagang Guo Honggen Chen Tianping Wang Xin Jiang Xu Rong Zhu Hongqing Zhu Chun Li Cao Dan Dan Lin Zhen Yuan Zhao Robert S Li George M Davis Donald P McManus |
author_facet |
Darren J Gray Aaron P Thrift Gail M Williams Feng Zheng Yue-Sheng Li Jiagang Guo Honggen Chen Tianping Wang Xin Jiang Xu Rong Zhu Hongqing Zhu Chun Li Cao Dan Dan Lin Zhen Yuan Zhao Robert S Li George M Davis Donald P McManus |
author_sort |
Darren J Gray |
title |
Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam. |
title_short |
Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam. |
title_full |
Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam. |
title_fullStr |
Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam. |
title_full_unstemmed |
Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam. |
title_sort |
five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the three gorges dam. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001588 https://doaj.org/article/ff2deb7013564b1a9b501940f762a7c0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1588 (2012) |
op_relation |
http://europepmc.org/articles/PMC3323517?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001588 https://doaj.org/article/ff2deb7013564b1a9b501940f762a7c0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001588 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
6 |
container_issue |
4 |
container_start_page |
e1588 |
_version_ |
1766347173267505152 |