Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis
Many trials have explored the efficacy of individual drugs and drug combinations to treat bancroftian filariasis. This narrative review summarizes the current evidence for drug management of bancroftian filariasis. Diethylcarbamazine (DEC) remains the prime antifilarial agent with a well-established...
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ftdoajarticles:oai:doaj.org/article:ff0cf969ac304a49a8057d4400212dbe 2024-09-09T19:24:47+00:00 Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis Sumadhya Deepika Fernando Chaturaka Rodrigo Senaka Rajapakse 2011-01-01T00:00:00Z https://doi.org/10.1155/2011/175941 https://doaj.org/article/ff0cf969ac304a49a8057d4400212dbe EN eng Wiley http://dx.doi.org/10.1155/2011/175941 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2011/175941 https://doaj.org/article/ff0cf969ac304a49a8057d4400212dbe Journal of Tropical Medicine, Vol 2011 (2011) Arctic medicine. Tropical medicine RC955-962 article 2011 ftdoajarticles https://doi.org/10.1155/2011/175941 2024-08-05T17:48:40Z Many trials have explored the efficacy of individual drugs and drug combinations to treat bancroftian filariasis. This narrative review summarizes the current evidence for drug management of bancroftian filariasis. Diethylcarbamazine (DEC) remains the prime antifilarial agent with a well-established microfilaricidal and some macrofilaricidal effects. Ivermectin (IVM) is highly microfilaricidal but minimally macrofilaricidal. The role of albendazole (ALB) in treatment regimens is not well established though the drug has a microfilaricidal effect. The combination of DEC+ALB has a better long-term impact than IVM+ALB. Recent trials have shown that doxycycline therapy against Wolbachia, an endosymbiotic bacterium of the parasite, is capable of reducing microfilaria rates and adult worm activity. Followup studies on mass drug administration (MDA) are yet to show a complete interruption of transmission, though the infection rates are reduced to a very low level. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2011 1 12 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Sumadhya Deepika Fernando Chaturaka Rodrigo Senaka Rajapakse Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Many trials have explored the efficacy of individual drugs and drug combinations to treat bancroftian filariasis. This narrative review summarizes the current evidence for drug management of bancroftian filariasis. Diethylcarbamazine (DEC) remains the prime antifilarial agent with a well-established microfilaricidal and some macrofilaricidal effects. Ivermectin (IVM) is highly microfilaricidal but minimally macrofilaricidal. The role of albendazole (ALB) in treatment regimens is not well established though the drug has a microfilaricidal effect. The combination of DEC+ALB has a better long-term impact than IVM+ALB. Recent trials have shown that doxycycline therapy against Wolbachia, an endosymbiotic bacterium of the parasite, is capable of reducing microfilaria rates and adult worm activity. Followup studies on mass drug administration (MDA) are yet to show a complete interruption of transmission, though the infection rates are reduced to a very low level. |
format |
Article in Journal/Newspaper |
author |
Sumadhya Deepika Fernando Chaturaka Rodrigo Senaka Rajapakse |
author_facet |
Sumadhya Deepika Fernando Chaturaka Rodrigo Senaka Rajapakse |
author_sort |
Sumadhya Deepika Fernando |
title |
Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
title_short |
Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
title_full |
Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
title_fullStr |
Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
title_full_unstemmed |
Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
title_sort |
current evidence on the use of antifilarial agents in the management of bancroftian filariasis |
publisher |
Wiley |
publishDate |
2011 |
url |
https://doi.org/10.1155/2011/175941 https://doaj.org/article/ff0cf969ac304a49a8057d4400212dbe |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2011 (2011) |
op_relation |
http://dx.doi.org/10.1155/2011/175941 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2011/175941 https://doaj.org/article/ff0cf969ac304a49a8057d4400212dbe |
op_doi |
https://doi.org/10.1155/2011/175941 |
container_title |
Journal of Tropical Medicine |
container_volume |
2011 |
container_start_page |
1 |
op_container_end_page |
12 |
_version_ |
1809894634883645440 |