Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain.
Digestive damage due to Chagas disease (CD) occurs in 15-20% of patients diagnosed as a result of peristaltic dysfunction in some endemic areas. The symptoms of chronic digestive CD are non-specific, and there are numerous confounders. Diagnosis of CD may easily be missed if symptoms are not evaluat...
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2014
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ftdoajarticles:oai:doaj.org/article:ff073d1e78904710b5884e7c6c5aabbf 2023-05-15T15:14:08+02:00 Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain. María-Jesús Pinazo Gloria Lacima José-Ignacio Elizalde Elizabeth-Jesús Posada Fausto Gimeno Edelweiss Aldasoro María-Eugenia Valls Joaquim Gascon 2014-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003105 https://doaj.org/article/ff073d1e78904710b5884e7c6c5aabbf EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4140677?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003105 https://doaj.org/article/ff073d1e78904710b5884e7c6c5aabbf PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3105 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003105 2022-12-31T12:37:29Z Digestive damage due to Chagas disease (CD) occurs in 15-20% of patients diagnosed as a result of peristaltic dysfunction in some endemic areas. The symptoms of chronic digestive CD are non-specific, and there are numerous confounders. Diagnosis of CD may easily be missed if symptoms are not evaluated by a well trained physician. Regular tests, as barium contrast examinations, probably lack the necessary sensitivity to detect early digestive damage.71 individuals with T. cruzi infection (G1) and 18 without (G2) coming from Latin American countries were analyzed. They were asked for clinical and epidemiological data, changes in dietary habits, and history targeting digestive and cardiac CD symptoms. Serological tests for T. cruzi, barium swallow, barium enema, an urea breath test, and esophageal manometry were requested for all patients.G1 and G2 patients did not show differences in lifestyle and past history. Fifteen (21.1%) of G1 had digestive involvement. Following Rezende criteria, esophagopathy was observed in 8 patients in G1 (11.3%) and in none of those in G2. Manometry disorders were recorded in 34 G1 patients and in six in G2. Isolated hypotensive lower esophageal sphincter (LES) was found in sixteen G1 patients (23.9%) and four G2 patients (28.8%). Achalasia was observed in two G1 patients. Among G1 patients, ineffective esophageal motility was seen in six (five with symptoms), diffuse esophageal spasm in two (one with dysphagia and regurgitation), and nutcracker esophagus in three (all with symptoms). There were six patients with hypertonic upper esophageal sphincter (UES) among G1. Following Ximenes criteria, megacolon was found in ten G1 patients (13.9%), and in none of the G2 patients.The prevalence of digestive chronic CD in our series was 21.1%. Dysphagia is a non-pathognomonic symptom of CD, but a good marker of early esophageal involvement. Manometry could be a useful diagnostic test in selected cases, mainly in patients with T. cruzi infection and dysphagia in whose situation barium swallow ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 8 e3105 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 María-Jesús Pinazo Gloria Lacima José-Ignacio Elizalde Elizabeth-Jesús Posada Fausto Gimeno Edelweiss Aldasoro María-Eugenia Valls Joaquim Gascon Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Digestive damage due to Chagas disease (CD) occurs in 15-20% of patients diagnosed as a result of peristaltic dysfunction in some endemic areas. The symptoms of chronic digestive CD are non-specific, and there are numerous confounders. Diagnosis of CD may easily be missed if symptoms are not evaluated by a well trained physician. Regular tests, as barium contrast examinations, probably lack the necessary sensitivity to detect early digestive damage.71 individuals with T. cruzi infection (G1) and 18 without (G2) coming from Latin American countries were analyzed. They were asked for clinical and epidemiological data, changes in dietary habits, and history targeting digestive and cardiac CD symptoms. Serological tests for T. cruzi, barium swallow, barium enema, an urea breath test, and esophageal manometry were requested for all patients.G1 and G2 patients did not show differences in lifestyle and past history. Fifteen (21.1%) of G1 had digestive involvement. Following Rezende criteria, esophagopathy was observed in 8 patients in G1 (11.3%) and in none of those in G2. Manometry disorders were recorded in 34 G1 patients and in six in G2. Isolated hypotensive lower esophageal sphincter (LES) was found in sixteen G1 patients (23.9%) and four G2 patients (28.8%). Achalasia was observed in two G1 patients. Among G1 patients, ineffective esophageal motility was seen in six (five with symptoms), diffuse esophageal spasm in two (one with dysphagia and regurgitation), and nutcracker esophagus in three (all with symptoms). There were six patients with hypertonic upper esophageal sphincter (UES) among G1. Following Ximenes criteria, megacolon was found in ten G1 patients (13.9%), and in none of the G2 patients.The prevalence of digestive chronic CD in our series was 21.1%. Dysphagia is a non-pathognomonic symptom of CD, but a good marker of early esophageal involvement. Manometry could be a useful diagnostic test in selected cases, mainly in patients with T. cruzi infection and dysphagia in whose situation barium swallow ... |
format |
Article in Journal/Newspaper |
author |
María-Jesús Pinazo Gloria Lacima José-Ignacio Elizalde Elizabeth-Jesús Posada Fausto Gimeno Edelweiss Aldasoro María-Eugenia Valls Joaquim Gascon |
author_facet |
María-Jesús Pinazo Gloria Lacima José-Ignacio Elizalde Elizabeth-Jesús Posada Fausto Gimeno Edelweiss Aldasoro María-Eugenia Valls Joaquim Gascon |
author_sort |
María-Jesús Pinazo |
title |
Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain. |
title_short |
Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain. |
title_full |
Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain. |
title_fullStr |
Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain. |
title_full_unstemmed |
Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain. |
title_sort |
characterization of digestive involvement in patients with chronic t. cruzi infection in barcelona, spain. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003105 https://doaj.org/article/ff073d1e78904710b5884e7c6c5aabbf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3105 (2014) |
op_relation |
http://europepmc.org/articles/PMC4140677?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003105 https://doaj.org/article/ff073d1e78904710b5884e7c6c5aabbf |
op_doi |
https://doi.org/10.1371/journal.pntd.0003105 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
8 |
container_start_page |
e3105 |
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1766344620508184576 |