Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia
Abstract INTRODUCTION: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades. The pathogenesis of Chagas cardiomyopathy involves the host inflammatory res...
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ftdoajarticles:oai:doaj.org/article:ff05e2c39877408c87eacfa2d2719497 2023-05-15T15:11:30+02:00 Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia Katherine Yih-Jia Fu Roxana Zamudio Jo Henderson-Frost Alex Almuedo Hannah Steinberg Steven Joseph Clipman Gustavo Duran Rachel Marcus Thomas Crawford Daniel Alyesh Rony Colanzi Jorge Flores Robert Hugh Gilman Caryn Bern https://doi.org/10.1590/0037-8682-0015-2017 https://doaj.org/article/ff05e2c39877408c87eacfa2d2719497 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000400516&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0015-2017 https://doaj.org/article/ff05e2c39877408c87eacfa2d2719497 Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 4, Pp 516-523 Chagas cardiomyopathy Single nucleotide polymorphisms Caspase-1 Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0015-2017 2022-12-31T03:20:45Z Abstract INTRODUCTION: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades. The pathogenesis of Chagas cardiomyopathy involves the host inflammatory response to T. cruzi, in which upstream caspase-1 activation prompts the cascade of inflammatory chemokines/cytokines, cardiac remodeling, and myocardial dysfunction. The aim of the present study was to examine the association of two caspase-1 single nucleotide polymorphisms (SNPs) with cardiomyopathy. METHODS: We recruited infected (Tc+, n = 149) and uninfected (Tc−, n = 87) participants in a hospital in Santa Cruz, Bolivia. Cardiac status was classified (I, II, III, IV) based on Chagas cardiomyopathy-associated electrocardiogram findings and ejection fractions on echocardiogram. Genotypes were determined using Taqman probes via reverse transcription-polymerase chain reaction of peripheral blood DNA. Genotype frequencies were analyzed according to three inheritance patterns (dominant, recessive, additive) using logistic regression adjusted for age and sex. RESULTS: The AA allele for the caspase-1 SNP rs501192 was more frequent in Tc+ cardiomyopathy (classes II, III, IV) patients compared to those with a normal cardiac status (class I) [odds ratio (OR) = −2.18, p = 0.117]. This trend approached statistical significant considering only Tc+ patients in class I and II (OR = −2.64, p = 0.064). CONCLUSIONS: Caspase-1 polymorphisms may play a role in Chagas cardiomyopathy development and could serve as markers to identify individuals at higher risk for priority treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 50 4 516 523 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Chagas cardiomyopathy Single nucleotide polymorphisms Caspase-1 Arctic medicine. Tropical medicine RC955-962 |
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Chagas cardiomyopathy Single nucleotide polymorphisms Caspase-1 Arctic medicine. Tropical medicine RC955-962 Katherine Yih-Jia Fu Roxana Zamudio Jo Henderson-Frost Alex Almuedo Hannah Steinberg Steven Joseph Clipman Gustavo Duran Rachel Marcus Thomas Crawford Daniel Alyesh Rony Colanzi Jorge Flores Robert Hugh Gilman Caryn Bern Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia |
topic_facet |
Chagas cardiomyopathy Single nucleotide polymorphisms Caspase-1 Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades. The pathogenesis of Chagas cardiomyopathy involves the host inflammatory response to T. cruzi, in which upstream caspase-1 activation prompts the cascade of inflammatory chemokines/cytokines, cardiac remodeling, and myocardial dysfunction. The aim of the present study was to examine the association of two caspase-1 single nucleotide polymorphisms (SNPs) with cardiomyopathy. METHODS: We recruited infected (Tc+, n = 149) and uninfected (Tc−, n = 87) participants in a hospital in Santa Cruz, Bolivia. Cardiac status was classified (I, II, III, IV) based on Chagas cardiomyopathy-associated electrocardiogram findings and ejection fractions on echocardiogram. Genotypes were determined using Taqman probes via reverse transcription-polymerase chain reaction of peripheral blood DNA. Genotype frequencies were analyzed according to three inheritance patterns (dominant, recessive, additive) using logistic regression adjusted for age and sex. RESULTS: The AA allele for the caspase-1 SNP rs501192 was more frequent in Tc+ cardiomyopathy (classes II, III, IV) patients compared to those with a normal cardiac status (class I) [odds ratio (OR) = −2.18, p = 0.117]. This trend approached statistical significant considering only Tc+ patients in class I and II (OR = −2.64, p = 0.064). CONCLUSIONS: Caspase-1 polymorphisms may play a role in Chagas cardiomyopathy development and could serve as markers to identify individuals at higher risk for priority treatment. |
format |
Article in Journal/Newspaper |
author |
Katherine Yih-Jia Fu Roxana Zamudio Jo Henderson-Frost Alex Almuedo Hannah Steinberg Steven Joseph Clipman Gustavo Duran Rachel Marcus Thomas Crawford Daniel Alyesh Rony Colanzi Jorge Flores Robert Hugh Gilman Caryn Bern |
author_facet |
Katherine Yih-Jia Fu Roxana Zamudio Jo Henderson-Frost Alex Almuedo Hannah Steinberg Steven Joseph Clipman Gustavo Duran Rachel Marcus Thomas Crawford Daniel Alyesh Rony Colanzi Jorge Flores Robert Hugh Gilman Caryn Bern |
author_sort |
Katherine Yih-Jia Fu |
title |
Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia |
title_short |
Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia |
title_full |
Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia |
title_fullStr |
Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia |
title_full_unstemmed |
Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia |
title_sort |
association of caspase-1 polymorphisms with chagas cardiomyopathy among individuals in santa cruz, bolivia |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0015-2017 https://doaj.org/article/ff05e2c39877408c87eacfa2d2719497 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 4, Pp 516-523 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000400516&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0015-2017 https://doaj.org/article/ff05e2c39877408c87eacfa2d2719497 |
op_doi |
https://doi.org/10.1590/0037-8682-0015-2017 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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50 |
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516 |
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