Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda
The emergence of hepatitis C virus (HCV) and its associated sequelae in Africa is a cause for significant concern. Human immunodeficiency virus (HIV) positive patients are at an increased risk of contracting HCV infection due to similar risk factors and modes of transmission. We investigated the ser...
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ftdoajarticles:oai:doaj.org/article:fee4ef8dc0b54cc0aebae2e112a3f522 2023-05-15T15:06:56+02:00 Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda J. I. O'Reilly P. Ocama C. K. Opio A. Alfred E. Paintsil E. Seremba A. N. Sofair 2011-01-01T00:00:00Z https://doi.org/10.1155/2011/598341 https://doaj.org/article/fee4ef8dc0b54cc0aebae2e112a3f522 EN eng Hindawi Limited http://dx.doi.org/10.1155/2011/598341 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2011/598341 https://doaj.org/article/fee4ef8dc0b54cc0aebae2e112a3f522 Journal of Tropical Medicine, Vol 2011 (2011) Arctic medicine. Tropical medicine RC955-962 article 2011 ftdoajarticles https://doi.org/10.1155/2011/598341 2022-12-31T13:15:37Z The emergence of hepatitis C virus (HCV) and its associated sequelae in Africa is a cause for significant concern. Human immunodeficiency virus (HIV) positive patients are at an increased risk of contracting HCV infection due to similar risk factors and modes of transmission. We investigated the seroprevalence of hepatitis C in hospitalized HIV-positive and HIV-negative patients in Mulago Hospital, an academic hospital in Uganda. Blood samples were first tested for HCV antibodies, and positive tests were confirmed with HCV RNA PCR. We enrolled five hundred patients, half HIV-positive and half HIV negative. Overall, 13/500 patients (2.6%) tested positive for HCV antibodies. There was no difference in HCV antibody detection among HIV-positive and HIV-negative patients. Out of all risk factors examined, only an age greater than 50 years was associated with HCV infection. Traditional risk factors for concurrent HIV and HCV transmission, such as intravenous drug use, were exceedingly rare in Uganda. Only 3 of 13 patients with detectable HCV antibodies were confirmed by HCV RNA detection. This result concurs with recent studies noting poor performance of HCV antibody testing when using African sera. These tests should be validated in the local population before implementation. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2011 1 6 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 J. I. O'Reilly P. Ocama C. K. Opio A. Alfred E. Paintsil E. Seremba A. N. Sofair Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
The emergence of hepatitis C virus (HCV) and its associated sequelae in Africa is a cause for significant concern. Human immunodeficiency virus (HIV) positive patients are at an increased risk of contracting HCV infection due to similar risk factors and modes of transmission. We investigated the seroprevalence of hepatitis C in hospitalized HIV-positive and HIV-negative patients in Mulago Hospital, an academic hospital in Uganda. Blood samples were first tested for HCV antibodies, and positive tests were confirmed with HCV RNA PCR. We enrolled five hundred patients, half HIV-positive and half HIV negative. Overall, 13/500 patients (2.6%) tested positive for HCV antibodies. There was no difference in HCV antibody detection among HIV-positive and HIV-negative patients. Out of all risk factors examined, only an age greater than 50 years was associated with HCV infection. Traditional risk factors for concurrent HIV and HCV transmission, such as intravenous drug use, were exceedingly rare in Uganda. Only 3 of 13 patients with detectable HCV antibodies were confirmed by HCV RNA detection. This result concurs with recent studies noting poor performance of HCV antibody testing when using African sera. These tests should be validated in the local population before implementation. |
format |
Article in Journal/Newspaper |
author |
J. I. O'Reilly P. Ocama C. K. Opio A. Alfred E. Paintsil E. Seremba A. N. Sofair |
author_facet |
J. I. O'Reilly P. Ocama C. K. Opio A. Alfred E. Paintsil E. Seremba A. N. Sofair |
author_sort |
J. I. O'Reilly |
title |
Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda |
title_short |
Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda |
title_full |
Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda |
title_fullStr |
Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda |
title_full_unstemmed |
Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda |
title_sort |
risk factors and seroprevalence of hepatitis c among patients hospitalized at mulago hospital, uganda |
publisher |
Hindawi Limited |
publishDate |
2011 |
url |
https://doi.org/10.1155/2011/598341 https://doaj.org/article/fee4ef8dc0b54cc0aebae2e112a3f522 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2011 (2011) |
op_relation |
http://dx.doi.org/10.1155/2011/598341 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2011/598341 https://doaj.org/article/fee4ef8dc0b54cc0aebae2e112a3f522 |
op_doi |
https://doi.org/10.1155/2011/598341 |
container_title |
Journal of Tropical Medicine |
container_volume |
2011 |
container_start_page |
1 |
op_container_end_page |
6 |
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1766338519246045184 |