Dengue in the Middle East and North Africa: A Systematic Review.
BACKGROUND:Dengue virus (DENV) infection is widespread and its disease burden has increased in past decades. However, little is known about the epidemiology of dengue in the Middle East and North Africa (MENA). METHODOLOGY / PRINCIPAL FINDINGS:Following Cochrane Collaboration guidelines and reportin...
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ftdoajarticles:oai:doaj.org/article:feafd7c241464effad2a82088c14960b 2023-05-15T15:12:55+02:00 Dengue in the Middle East and North Africa: A Systematic Review. John M Humphrey Natalie B Cleton Chantal B E M Reusken Marshall J Glesby Marion P G Koopmans Laith J Abu-Raddad 2016-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005194 https://doaj.org/article/feafd7c241464effad2a82088c14960b EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5142774?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005194 https://doaj.org/article/feafd7c241464effad2a82088c14960b PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005194 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005194 2022-12-31T03:16:55Z BACKGROUND:Dengue virus (DENV) infection is widespread and its disease burden has increased in past decades. However, little is known about the epidemiology of dengue in the Middle East and North Africa (MENA). METHODOLOGY / PRINCIPAL FINDINGS:Following Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed available records across MENA describing dengue occurrence in humans (prevalence studies, incidence studies, and outbreak reports), occurrence of suitable vectors (Aedes aegypti and Aedes albopictus), and DENV vector infection rates. We identified 105 human prevalence measures in 13 of 24 MENA countries; 81 outbreaks reported from 9 countries from 1941-2015; and reports of Ae. aegypti and/or Ae. albopictus occurrence in 15 countries. The majority of seroprevalence studies were reported from the Red Sea region and Pakistan, with multiple studies indicating >20% DENV seroprevalence in general populations (median 25%, range 0-62%) in these subregions. Fifty percent of these studies were conducted prior to 1990. Multiple studies utilized assays susceptible to serologic cross-reactions and 5% of seroprevalence studies utilized viral neutralization testing. There was considerable heterogeneity in study design and outbreak reporting, as well as variability in subregional study coverage, study populations, and laboratory methods used for diagnosis. CONCLUSIONS / SIGNIFICANCE:DENV seroprevalence in the MENA is high among some populations in the Red Sea region and Pakistan, while recent outbreaks in these subregions suggest increasing incidence of DENV which may be driven by a variety of ecologic and social factors. However, there is insufficient study coverage to draw conclusions about Aedes or DENV presence in multiple MENA countries. These findings illustrate the epidemiology of DENV in the MENA while revealing priorities for DENV surveillance and Aedes control. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) PLOS Neglected Tropical Diseases 10 12 e0005194 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 John M Humphrey Natalie B Cleton Chantal B E M Reusken Marshall J Glesby Marion P G Koopmans Laith J Abu-Raddad Dengue in the Middle East and North Africa: A Systematic Review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Dengue virus (DENV) infection is widespread and its disease burden has increased in past decades. However, little is known about the epidemiology of dengue in the Middle East and North Africa (MENA). METHODOLOGY / PRINCIPAL FINDINGS:Following Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed available records across MENA describing dengue occurrence in humans (prevalence studies, incidence studies, and outbreak reports), occurrence of suitable vectors (Aedes aegypti and Aedes albopictus), and DENV vector infection rates. We identified 105 human prevalence measures in 13 of 24 MENA countries; 81 outbreaks reported from 9 countries from 1941-2015; and reports of Ae. aegypti and/or Ae. albopictus occurrence in 15 countries. The majority of seroprevalence studies were reported from the Red Sea region and Pakistan, with multiple studies indicating >20% DENV seroprevalence in general populations (median 25%, range 0-62%) in these subregions. Fifty percent of these studies were conducted prior to 1990. Multiple studies utilized assays susceptible to serologic cross-reactions and 5% of seroprevalence studies utilized viral neutralization testing. There was considerable heterogeneity in study design and outbreak reporting, as well as variability in subregional study coverage, study populations, and laboratory methods used for diagnosis. CONCLUSIONS / SIGNIFICANCE:DENV seroprevalence in the MENA is high among some populations in the Red Sea region and Pakistan, while recent outbreaks in these subregions suggest increasing incidence of DENV which may be driven by a variety of ecologic and social factors. However, there is insufficient study coverage to draw conclusions about Aedes or DENV presence in multiple MENA countries. These findings illustrate the epidemiology of DENV in the MENA while revealing priorities for DENV surveillance and Aedes control. |
format |
Article in Journal/Newspaper |
author |
John M Humphrey Natalie B Cleton Chantal B E M Reusken Marshall J Glesby Marion P G Koopmans Laith J Abu-Raddad |
author_facet |
John M Humphrey Natalie B Cleton Chantal B E M Reusken Marshall J Glesby Marion P G Koopmans Laith J Abu-Raddad |
author_sort |
John M Humphrey |
title |
Dengue in the Middle East and North Africa: A Systematic Review. |
title_short |
Dengue in the Middle East and North Africa: A Systematic Review. |
title_full |
Dengue in the Middle East and North Africa: A Systematic Review. |
title_fullStr |
Dengue in the Middle East and North Africa: A Systematic Review. |
title_full_unstemmed |
Dengue in the Middle East and North Africa: A Systematic Review. |
title_sort |
dengue in the middle east and north africa: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005194 https://doaj.org/article/feafd7c241464effad2a82088c14960b |
long_lat |
ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Arctic Prisma |
geographic_facet |
Arctic Prisma |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005194 (2016) |
op_relation |
http://europepmc.org/articles/PMC5142774?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005194 https://doaj.org/article/feafd7c241464effad2a82088c14960b |
op_doi |
https://doi.org/10.1371/journal.pntd.0005194 |
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PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
12 |
container_start_page |
e0005194 |
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