Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging
Fish species exhibit great diversity rating of aging (from negligible to rapid), which gives a unique possibility for the discovery of the molecular mechanisms that determine the differences in the rate of aging. A mass spectrometric metabolic profiling of skeletal muscle of fish with various aging...
Published in: | Fishes |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2019
|
Subjects: | |
Online Access: | https://doi.org/10.3390/fishes4020025 https://doaj.org/article/fea63176f7da41e28a1d5daac94467f5 |
id |
ftdoajarticles:oai:doaj.org/article:fea63176f7da41e28a1d5daac94467f5 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:fea63176f7da41e28a1d5daac94467f5 2023-05-15T17:52:51+02:00 Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging Dmitry L. Maslov Oxana P. Trifonova Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov 2019-03-01T00:00:00Z https://doi.org/10.3390/fishes4020025 https://doaj.org/article/fea63176f7da41e28a1d5daac94467f5 EN eng MDPI AG https://www.mdpi.com/2410-3888/4/2/25 https://doaj.org/toc/2410-3888 2410-3888 doi:10.3390/fishes4020025 https://doaj.org/article/fea63176f7da41e28a1d5daac94467f5 Fishes, Vol 4, Iss 2, Pp 25-0 (2019) aging metabolome profiling muscle fish Biology (General) QH301-705.5 Genetics QH426-470 article 2019 ftdoajarticles https://doi.org/10.3390/fishes4020025 2022-12-31T12:48:29Z Fish species exhibit great diversity rating of aging (from negligible to rapid), which gives a unique possibility for the discovery of the molecular mechanisms that determine the differences in the rate of aging. A mass spectrometric metabolic profiling of skeletal muscle of fish with various aging rates was carried out by direct injection to a quadrupole time-of-flight mass spectrometer. The first group includes long-lived fish species (pike ( Esox Lucius ) and sterlet ( Acipenser ruthenus ); the second group—species with gradual senescence such as that observed in many mammalian species of similar size (zander ( Sandra lucioperca ) and perch ( Perca fluviatilis )) and the third group—species with very short life cycle (chum salmon ( Oncorhynchus keta ) and pink salmon ( Oncorhynchus gorbuscha )). Multivariate analysis of metabolic profiles allowed the detecting of about 80 group-specific features associated with amino acids, lipids, biogenic amines, intermediates of glycolysis, glycogenolysis, and citric acid cycle. Possible roles in the aging process are hypothesized for the biochemical pathways of the metabolites that were altered in the different groups. Article in Journal/Newspaper Oncorhynchus gorbuscha Pink salmon Directory of Open Access Journals: DOAJ Articles Keta ENVELOPE(-19.455,-19.455,65.656,65.656) Fishes 4 2 25 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
aging metabolome profiling muscle fish Biology (General) QH301-705.5 Genetics QH426-470 |
spellingShingle |
aging metabolome profiling muscle fish Biology (General) QH301-705.5 Genetics QH426-470 Dmitry L. Maslov Oxana P. Trifonova Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
topic_facet |
aging metabolome profiling muscle fish Biology (General) QH301-705.5 Genetics QH426-470 |
description |
Fish species exhibit great diversity rating of aging (from negligible to rapid), which gives a unique possibility for the discovery of the molecular mechanisms that determine the differences in the rate of aging. A mass spectrometric metabolic profiling of skeletal muscle of fish with various aging rates was carried out by direct injection to a quadrupole time-of-flight mass spectrometer. The first group includes long-lived fish species (pike ( Esox Lucius ) and sterlet ( Acipenser ruthenus ); the second group—species with gradual senescence such as that observed in many mammalian species of similar size (zander ( Sandra lucioperca ) and perch ( Perca fluviatilis )) and the third group—species with very short life cycle (chum salmon ( Oncorhynchus keta ) and pink salmon ( Oncorhynchus gorbuscha )). Multivariate analysis of metabolic profiles allowed the detecting of about 80 group-specific features associated with amino acids, lipids, biogenic amines, intermediates of glycolysis, glycogenolysis, and citric acid cycle. Possible roles in the aging process are hypothesized for the biochemical pathways of the metabolites that were altered in the different groups. |
format |
Article in Journal/Newspaper |
author |
Dmitry L. Maslov Oxana P. Trifonova Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov |
author_facet |
Dmitry L. Maslov Oxana P. Trifonova Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov |
author_sort |
Dmitry L. Maslov |
title |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_short |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_full |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_fullStr |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_full_unstemmed |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_sort |
comparative analysis of skeletal muscle metabolites of fish with various rates of aging |
publisher |
MDPI AG |
publishDate |
2019 |
url |
https://doi.org/10.3390/fishes4020025 https://doaj.org/article/fea63176f7da41e28a1d5daac94467f5 |
long_lat |
ENVELOPE(-19.455,-19.455,65.656,65.656) |
geographic |
Keta |
geographic_facet |
Keta |
genre |
Oncorhynchus gorbuscha Pink salmon |
genre_facet |
Oncorhynchus gorbuscha Pink salmon |
op_source |
Fishes, Vol 4, Iss 2, Pp 25-0 (2019) |
op_relation |
https://www.mdpi.com/2410-3888/4/2/25 https://doaj.org/toc/2410-3888 2410-3888 doi:10.3390/fishes4020025 https://doaj.org/article/fea63176f7da41e28a1d5daac94467f5 |
op_doi |
https://doi.org/10.3390/fishes4020025 |
container_title |
Fishes |
container_volume |
4 |
container_issue |
2 |
container_start_page |
25 |
_version_ |
1766160589469515776 |