Histoplasma capsulatum fungemia in patients with acquired immunodeficiency syndrome: detection by lysis-centrifugation blood-culturing technique Fungemia por Histoplasma capsulatum em pacientes com a síndrome da imunodeficiência adquirida: detecção através da técnica de hemocultivo por lise-centrifugação

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Flávio de Mattos Oliveira, Sérgio Sônego Fernandes, Cecília Bittencourt Severo, Luciana Silva Guazzelli, Luiz Carlos Severo
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2007
• Subjects: Histoplasma capsulatum; Histoplasmosis; Lysis-centrifugation; Fungemia; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46652007000300001; https://doaj.org/article/fdbc409216ba4c25a1004a948c0180b7

Progressive disseminated histoplasmosis (PDH) is an increasingly common cause of infection in patients with acquired immune deficiency syndrome (AIDS). We report 21 cases of PDH associated with AIDS diagnosed by lysis-centrifugation blood culture method. The most prevalent clinical findings were fever, weight loss, respiratory symptoms, and mucocutaneous lesions. Chest roentgenogram showed diffuse pulmonary infiltrates in 13 of 21 patients (62%). Brochoalveolar fluid has yelded positive culture in four patients only in medium with cycloheximide. Histoplasmose progressiva disseminada (HPD) tem aumentado e é causa comum de infecção em pacientes com síndrome da imunodeficiência adquirida (Aids). Relatamos 21 casos de HPD associado com Aids diagnosticada pela técnica de hemocultivo por lise-centrifugação. Os achados clínicos mais prevalentes foram febre, perda de peso, sintomas respiratórios e lesões mucocutâneas. Raios X de tórax mostrou infiltrados pulmonares difusos em 13 dos 21 pacientes (62%). Amostras de lavado broncoalveolar foram positivos em apenas 4 pacientes através de meio com cicloheximida.