Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study
Marit Waaseth,1,2 Martina Havelkova,1 Guro Forsdahl,1 Eiliv Lund,3 Tomas Log2,4 1Department of Pharmacy, UiT the Arctic University of Norway, Tromsø, Norway; 2Northern Norway Regional Health Authority, Tromsø, Norway; 3Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, No...
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ftdoajarticles:oai:doaj.org/article:fd883aacdc7346d5bfdb3b75cbf9f425 2023-05-15T17:13:00+02:00 Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study Waaseth M Havelkova M Forsdahl G Lund E Log T 2022-06-01T00:00:00Z https://doaj.org/article/fd883aacdc7346d5bfdb3b75cbf9f425 EN eng Dove Medical Press https://www.dovepress.com/use-of-selective-serotonin-reuptake-inhibitors--validity-of-self-repor-peer-reviewed-fulltext-article-CLEP https://doaj.org/toc/1179-1349 1179-1349 https://doaj.org/article/fd883aacdc7346d5bfdb3b75cbf9f425 Clinical Epidemiology, Vol Volume 14, Pp 815-826 (2022) antidepressants self-report plasma concentration pharmacy dispensations record linkage agreement Infectious and parasitic diseases RC109-216 article 2022 ftdoajarticles 2022-12-31T02:48:17Z Marit Waaseth,1,2 Martina Havelkova,1 Guro Forsdahl,1 Eiliv Lund,3 Tomas Log2,4 1Department of Pharmacy, UiT the Arctic University of Norway, Tromsø, Norway; 2Northern Norway Regional Health Authority, Tromsø, Norway; 3Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway; 4Faculty of Nursing and Health Sciences, Nord University, Mo i Rana, NorwayCorrespondence: Marit Waaseth, Department of Pharmacy, UiT The arctic university of Norway, PO Box 6050 Langnes, Tromsø, N-9037, Norway, Tel +47 776 46192, Email marit.waaseth@uit.noPurpose: To validate self-reported current use of selective serotonin reuptake inhibitors (SSRI) in the Norwegian Women and Cancer study (NOWAC) and to identify factors associated with discordance between data sources.Material and Methods: This is a cross-sectional record-linkage study comparing SSRI-use derived from four data sources: 1) Specific SSRI questions in the main NOWAC questionnaire, 2) Open questions on medication use in the small questionnaire following blood samples, 3) plasma concentration measurements for a subsample, and 4) pharmacy dispensations from the Norwegian prescription database (NorPD) where current use of SSRI was defined by Legend Time Duration (LTD). Among 105 855 women, aged 46 to 64 years and randomly selected from the general population, 70,191 had data on SSRI-use from both NOWAC and NorPD. Plasma concentration was measured for 93 pairs of self-reported SSRI-users and non-users, with dispensation data available for 68 pairs. Validity was assessed by sensitivity and specificity; agreement was assessed by Cohen’s kappa. Factors associated with discordance between information sources were analyzed by multiple binary logistic regression.Results: We found high sensitivity (89.5%) and specificity (98.7%) for the specific questions in the main questionnaire compared with pharmacy dispensations. Measured against plasma concentrations, current SSRI-use defined by open questions and pharmacy dispensations both had high sensitivity (100% ... Article in Journal/Newspaper Mo i Rana Tromsø Arctic University of Norway UiT The Arctic University of Norway Directory of Open Access Journals: DOAJ Articles Arctic Norway Tromsø Martina ENVELOPE(-75.217,-75.217,-69.783,-69.783) Mo i Rana ENVELOPE(14.133,14.133,66.310,66.310) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antidepressants self-report plasma concentration pharmacy dispensations record linkage agreement Infectious and parasitic diseases RC109-216 |
spellingShingle |
antidepressants self-report plasma concentration pharmacy dispensations record linkage agreement Infectious and parasitic diseases RC109-216 Waaseth M Havelkova M Forsdahl G Lund E Log T Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study |
topic_facet |
antidepressants self-report plasma concentration pharmacy dispensations record linkage agreement Infectious and parasitic diseases RC109-216 |
description |
Marit Waaseth,1,2 Martina Havelkova,1 Guro Forsdahl,1 Eiliv Lund,3 Tomas Log2,4 1Department of Pharmacy, UiT the Arctic University of Norway, Tromsø, Norway; 2Northern Norway Regional Health Authority, Tromsø, Norway; 3Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway; 4Faculty of Nursing and Health Sciences, Nord University, Mo i Rana, NorwayCorrespondence: Marit Waaseth, Department of Pharmacy, UiT The arctic university of Norway, PO Box 6050 Langnes, Tromsø, N-9037, Norway, Tel +47 776 46192, Email marit.waaseth@uit.noPurpose: To validate self-reported current use of selective serotonin reuptake inhibitors (SSRI) in the Norwegian Women and Cancer study (NOWAC) and to identify factors associated with discordance between data sources.Material and Methods: This is a cross-sectional record-linkage study comparing SSRI-use derived from four data sources: 1) Specific SSRI questions in the main NOWAC questionnaire, 2) Open questions on medication use in the small questionnaire following blood samples, 3) plasma concentration measurements for a subsample, and 4) pharmacy dispensations from the Norwegian prescription database (NorPD) where current use of SSRI was defined by Legend Time Duration (LTD). Among 105 855 women, aged 46 to 64 years and randomly selected from the general population, 70,191 had data on SSRI-use from both NOWAC and NorPD. Plasma concentration was measured for 93 pairs of self-reported SSRI-users and non-users, with dispensation data available for 68 pairs. Validity was assessed by sensitivity and specificity; agreement was assessed by Cohen’s kappa. Factors associated with discordance between information sources were analyzed by multiple binary logistic regression.Results: We found high sensitivity (89.5%) and specificity (98.7%) for the specific questions in the main questionnaire compared with pharmacy dispensations. Measured against plasma concentrations, current SSRI-use defined by open questions and pharmacy dispensations both had high sensitivity (100% ... |
format |
Article in Journal/Newspaper |
author |
Waaseth M Havelkova M Forsdahl G Lund E Log T |
author_facet |
Waaseth M Havelkova M Forsdahl G Lund E Log T |
author_sort |
Waaseth M |
title |
Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study |
title_short |
Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study |
title_full |
Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study |
title_fullStr |
Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study |
title_full_unstemmed |
Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study |
title_sort |
use of selective serotonin reuptake inhibitors – validity of self-report versus plasma concentrations and pharmacy dispensations – a cross-sectional analysis of the norwegian women and cancer study |
publisher |
Dove Medical Press |
publishDate |
2022 |
url |
https://doaj.org/article/fd883aacdc7346d5bfdb3b75cbf9f425 |
long_lat |
ENVELOPE(-75.217,-75.217,-69.783,-69.783) ENVELOPE(14.133,14.133,66.310,66.310) |
geographic |
Arctic Norway Tromsø Martina Mo i Rana |
geographic_facet |
Arctic Norway Tromsø Martina Mo i Rana |
genre |
Mo i Rana Tromsø Arctic University of Norway UiT The Arctic University of Norway |
genre_facet |
Mo i Rana Tromsø Arctic University of Norway UiT The Arctic University of Norway |
op_source |
Clinical Epidemiology, Vol Volume 14, Pp 815-826 (2022) |
op_relation |
https://www.dovepress.com/use-of-selective-serotonin-reuptake-inhibitors--validity-of-self-repor-peer-reviewed-fulltext-article-CLEP https://doaj.org/toc/1179-1349 1179-1349 https://doaj.org/article/fd883aacdc7346d5bfdb3b75cbf9f425 |
_version_ |
1766069900112035840 |