Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole
An electron microscopy study shows that the administration of a single dose (500 mg/kg, p.o.) of 2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1, 3, 4-thiadiazole induces in mice infected with Trypanosoma cruzi results in degenerative lesions of the intracellular stages. Ultrastructural alterations are...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1984
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ftdoajarticles:oai:doaj.org/article:fd55e8a7a2a44880a710a69162ac16ac 2023-05-15T15:11:09+02:00 Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole Thaisa de Almeida Maria Leny de Sousa Filardi Zigman Brener 1984-06-01T00:00:00Z https://doaj.org/article/fd55e8a7a2a44880a710a69162ac16ac EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821984000200008 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/fd55e8a7a2a44880a710a69162ac16ac Revista da Sociedade Brasileira de Medicina Tropical, Vol 17, Iss 2, Pp 89-93 (1984) Trypanosoma cruzi Nitroimidazol - Tiadiazole Microscopia eletrônica Nitroimidazo-thiadiazole Electron microscopy Arctic medicine. Tropical medicine RC955-962 article 1984 ftdoajarticles 2022-12-30T23:10:33Z An electron microscopy study shows that the administration of a single dose (500 mg/kg, p.o.) of 2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1, 3, 4-thiadiazole induces in mice infected with Trypanosoma cruzi results in degenerative lesions of the intracellular stages. Ultrastructural alterations are detected as early as 6 hours after the drug administration and destruction of the parasites occurs within 18 - 36 hours. Trypomastigotes are cleared from the bloodstream 4 to 6 hours after treatment. The combined effect on both developmental stages is apparently responsible for the in vivo ejfects of this drug which is the most active drug ever tested in our laboratory in experimental Chagas' disease. Um estudo com microscopia eletrônica mostrou que a administração de dose única (500 mg/kg, p.o.) do composto 2-amino-5-(1-metil-5-nitro-2-imidazolil)-1 3, 4-tiadiazole induz, em camundongos inoculados com T. cruzi, lesões degenerativas das formas intracelulares do parasita. Alterações ultra estruturais são observadas 6 horas após a administração da droga e destruição ocorre em 18-36 horas. Tripomastigotas também desaparecem do sangue circulante dos animais 4-6 horas após o tratamento. O efeito em ambos os estágios evolutivos do T. cruzi é aparentemente responsável pelos efeitos in vivo desse derivado que é o mais ativo composto já testado em nosso laboratório na doença de Chagas. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Droga ENVELOPE(6.521,6.521,62.644,62.644) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Trypanosoma cruzi Nitroimidazol - Tiadiazole Microscopia eletrônica Nitroimidazo-thiadiazole Electron microscopy Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Trypanosoma cruzi Nitroimidazol - Tiadiazole Microscopia eletrônica Nitroimidazo-thiadiazole Electron microscopy Arctic medicine. Tropical medicine RC955-962 Thaisa de Almeida Maria Leny de Sousa Filardi Zigman Brener Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole |
topic_facet |
Trypanosoma cruzi Nitroimidazol - Tiadiazole Microscopia eletrônica Nitroimidazo-thiadiazole Electron microscopy Arctic medicine. Tropical medicine RC955-962 |
description |
An electron microscopy study shows that the administration of a single dose (500 mg/kg, p.o.) of 2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1, 3, 4-thiadiazole induces in mice infected with Trypanosoma cruzi results in degenerative lesions of the intracellular stages. Ultrastructural alterations are detected as early as 6 hours after the drug administration and destruction of the parasites occurs within 18 - 36 hours. Trypomastigotes are cleared from the bloodstream 4 to 6 hours after treatment. The combined effect on both developmental stages is apparently responsible for the in vivo ejfects of this drug which is the most active drug ever tested in our laboratory in experimental Chagas' disease. Um estudo com microscopia eletrônica mostrou que a administração de dose única (500 mg/kg, p.o.) do composto 2-amino-5-(1-metil-5-nitro-2-imidazolil)-1 3, 4-tiadiazole induz, em camundongos inoculados com T. cruzi, lesões degenerativas das formas intracelulares do parasita. Alterações ultra estruturais são observadas 6 horas após a administração da droga e destruição ocorre em 18-36 horas. Tripomastigotas também desaparecem do sangue circulante dos animais 4-6 horas após o tratamento. O efeito em ambos os estágios evolutivos do T. cruzi é aparentemente responsável pelos efeitos in vivo desse derivado que é o mais ativo composto já testado em nosso laboratório na doença de Chagas. |
format |
Article in Journal/Newspaper |
author |
Thaisa de Almeida Maria Leny de Sousa Filardi Zigman Brener |
author_facet |
Thaisa de Almeida Maria Leny de Sousa Filardi Zigman Brener |
author_sort |
Thaisa de Almeida Maria |
title |
Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole |
title_short |
Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole |
title_full |
Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole |
title_fullStr |
Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole |
title_full_unstemmed |
Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole |
title_sort |
ultrastructural alterations of intracellular stages and effects on blood forms of trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - thiadiazole |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1984 |
url |
https://doaj.org/article/fd55e8a7a2a44880a710a69162ac16ac |
long_lat |
ENVELOPE(6.521,6.521,62.644,62.644) |
geographic |
Arctic Droga |
geographic_facet |
Arctic Droga |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 17, Iss 2, Pp 89-93 (1984) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821984000200008 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/fd55e8a7a2a44880a710a69162ac16ac |
_version_ |
1766342059451482112 |