Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review

Crimean-Congo hemorrhagic fever virus (CCHFV) is responsible for widespread tick-borne zoonotic viral disease CCHF in African, Middle Eastern, Asian, and European countries. CCHFV can be spread to humans through tick bites or contact with infected animals or humans, and it often progresses from asym...

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Published in:Asian Pacific Journal of Tropical Medicine
Main Authors: Mohammad Ali Hamidinejad, Hadi Esmaeili Gouvarchin Ghaleh, Mahdieh Farzanehpour, Masoumeh Bolandian, Ruhollah Dorostkar
Format: Article in Journal/Newspaper
Language:English
Published: Wolters Kluwer Medknow Publications 2021
Subjects:
Online Access:https://doi.org/10.4103/1995-7645.315899
https://doaj.org/article/fcaa524e143947968090be5a2b12ae13
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spelling ftdoajarticles:oai:doaj.org/article:fcaa524e143947968090be5a2b12ae13 2023-05-15T15:06:56+02:00 Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review Mohammad Ali Hamidinejad Hadi Esmaeili Gouvarchin Ghaleh Mahdieh Farzanehpour Masoumeh Bolandian Ruhollah Dorostkar 2021-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.315899 https://doaj.org/article/fcaa524e143947968090be5a2b12ae13 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=6;spage=254;epage=265;aulast=Hamidinejad https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.315899 https://doaj.org/article/fcaa524e143947968090be5a2b12ae13 Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 6, Pp 254-265 (2021) crimean-congo hemorrhagic fever virus (cchfv) cchf disease immunopathogenesis animal models diagnosis vaccines therapeutic approaches Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.4103/1995-7645.315899 2022-12-30T19:54:37Z Crimean-Congo hemorrhagic fever virus (CCHFV) is responsible for widespread tick-borne zoonotic viral disease CCHF in African, Middle Eastern, Asian, and European countries. CCHFV can be spread to humans through tick bites or contact with infected animals or humans, and it often progresses from asymptomatic to severe/lethal illness, with fatality rates ranging from 10% to 40% in humans. Today, CCHF is growing into a significant public health concern due to its very high prevalence, severity of the condition, and lack of available vaccines and specific treatments. Recent research has been drawn towards a more accurate study of CCHFV characteristics, including the structure, genetic diversity, mechanisms involved in pathogenesis and immunopathogenesis, and clinical features. In addition, the use of animal models (mouse and non-human primates) and advanced diagnostic tools in recent years has resulted in a significant advance in CCHF related studies. In this context, we summarized the latest findings about CCHF research, its health complications, animal models, current diagnosis, vaccination, and CCHF treatments, and therapeutic strategies. Furthermore, we discussed existing deficiencies and problems in CCHFV analysis, as well as areas that still need to yield conclusive answers. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 14 6 254
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic crimean-congo hemorrhagic fever virus (cchfv)
cchf disease
immunopathogenesis
animal models
diagnosis
vaccines
therapeutic approaches
Arctic medicine. Tropical medicine
RC955-962
spellingShingle crimean-congo hemorrhagic fever virus (cchfv)
cchf disease
immunopathogenesis
animal models
diagnosis
vaccines
therapeutic approaches
Arctic medicine. Tropical medicine
RC955-962
Mohammad Ali Hamidinejad
Hadi Esmaeili Gouvarchin Ghaleh
Mahdieh Farzanehpour
Masoumeh Bolandian
Ruhollah Dorostkar
Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review
topic_facet crimean-congo hemorrhagic fever virus (cchfv)
cchf disease
immunopathogenesis
animal models
diagnosis
vaccines
therapeutic approaches
Arctic medicine. Tropical medicine
RC955-962
description Crimean-Congo hemorrhagic fever virus (CCHFV) is responsible for widespread tick-borne zoonotic viral disease CCHF in African, Middle Eastern, Asian, and European countries. CCHFV can be spread to humans through tick bites or contact with infected animals or humans, and it often progresses from asymptomatic to severe/lethal illness, with fatality rates ranging from 10% to 40% in humans. Today, CCHF is growing into a significant public health concern due to its very high prevalence, severity of the condition, and lack of available vaccines and specific treatments. Recent research has been drawn towards a more accurate study of CCHFV characteristics, including the structure, genetic diversity, mechanisms involved in pathogenesis and immunopathogenesis, and clinical features. In addition, the use of animal models (mouse and non-human primates) and advanced diagnostic tools in recent years has resulted in a significant advance in CCHF related studies. In this context, we summarized the latest findings about CCHF research, its health complications, animal models, current diagnosis, vaccination, and CCHF treatments, and therapeutic strategies. Furthermore, we discussed existing deficiencies and problems in CCHFV analysis, as well as areas that still need to yield conclusive answers.
format Article in Journal/Newspaper
author Mohammad Ali Hamidinejad
Hadi Esmaeili Gouvarchin Ghaleh
Mahdieh Farzanehpour
Masoumeh Bolandian
Ruhollah Dorostkar
author_facet Mohammad Ali Hamidinejad
Hadi Esmaeili Gouvarchin Ghaleh
Mahdieh Farzanehpour
Masoumeh Bolandian
Ruhollah Dorostkar
author_sort Mohammad Ali Hamidinejad
title Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review
title_short Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review
title_full Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review
title_fullStr Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review
title_full_unstemmed Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review
title_sort crimean-congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: a scoping review
publisher Wolters Kluwer Medknow Publications
publishDate 2021
url https://doi.org/10.4103/1995-7645.315899
https://doaj.org/article/fcaa524e143947968090be5a2b12ae13
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 6, Pp 254-265 (2021)
op_relation http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=6;spage=254;epage=265;aulast=Hamidinejad
https://doaj.org/toc/2352-4146
2352-4146
doi:10.4103/1995-7645.315899
https://doaj.org/article/fcaa524e143947968090be5a2b12ae13
op_doi https://doi.org/10.4103/1995-7645.315899
container_title Asian Pacific Journal of Tropical Medicine
container_volume 14
container_issue 6
container_start_page 254
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