Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy.
Genes encoding the major histocompatibility complex (MHC) have been thought to play a vital role in the adaptive immune system in all vertebrates. The discovery that Atlantic cod (Gadus morhua) has lost important components of the MHC II pathway, accompanied by an unusually high number of MHC I gene...
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ftdoajarticles:oai:doaj.org/article:fc7581d0cf0d44e6939170685a94814f 2023-05-15T15:27:35+02:00 Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy. Martin Malmstrøm Sissel Jentoft Tone F Gregers Kjetill S Jakobsen 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0074004 https://doaj.org/article/fc7581d0cf0d44e6939170685a94814f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3760826?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0074004 https://doaj.org/article/fc7581d0cf0d44e6939170685a94814f PLoS ONE, Vol 8, Iss 9, p e74004 (2013) Medicine R Science Q article 2013 ftdoajarticles https://doi.org/10.1371/journal.pone.0074004 2022-12-31T16:26:05Z Genes encoding the major histocompatibility complex (MHC) have been thought to play a vital role in the adaptive immune system in all vertebrates. The discovery that Atlantic cod (Gadus morhua) has lost important components of the MHC II pathway, accompanied by an unusually high number of MHC I genes, shed new light on the evolution and plasticity of the immune system of teleosts as well as in higher vertebrates. The overall aim of this study was to further investigate the highly expanded repertoire of MHC I genes using a cDNA approach to obtain sequence information of both the binding domains and the sorting signaling potential in the cytoplasmic tail. Here we report a novel combination of two endosomal sorting motifs, one tyrosine-based associated with exogenous peptide presentation by cross-presenting MHCI molecules, and one dileucine-based associated with normal MHC II functionality. The two signal motifs were identified in the cytoplasmic tail in a subset of the genes. This indicates that these genes have evolved MHC II-like functionality, allowing a more versatile use of MHC I through cross-presentation. Such an alternative immune strategy may have arisen through adaptive radiation and acquisition of new gene function as a response to changes in the habitat of its ancestral lineage. Article in Journal/Newspaper atlantic cod Gadus morhua Directory of Open Access Journals: DOAJ Articles PLoS ONE 8 9 e74004 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Medicine R Science Q |
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Medicine R Science Q Martin Malmstrøm Sissel Jentoft Tone F Gregers Kjetill S Jakobsen Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy. |
topic_facet |
Medicine R Science Q |
description |
Genes encoding the major histocompatibility complex (MHC) have been thought to play a vital role in the adaptive immune system in all vertebrates. The discovery that Atlantic cod (Gadus morhua) has lost important components of the MHC II pathway, accompanied by an unusually high number of MHC I genes, shed new light on the evolution and plasticity of the immune system of teleosts as well as in higher vertebrates. The overall aim of this study was to further investigate the highly expanded repertoire of MHC I genes using a cDNA approach to obtain sequence information of both the binding domains and the sorting signaling potential in the cytoplasmic tail. Here we report a novel combination of two endosomal sorting motifs, one tyrosine-based associated with exogenous peptide presentation by cross-presenting MHCI molecules, and one dileucine-based associated with normal MHC II functionality. The two signal motifs were identified in the cytoplasmic tail in a subset of the genes. This indicates that these genes have evolved MHC II-like functionality, allowing a more versatile use of MHC I through cross-presentation. Such an alternative immune strategy may have arisen through adaptive radiation and acquisition of new gene function as a response to changes in the habitat of its ancestral lineage. |
format |
Article in Journal/Newspaper |
author |
Martin Malmstrøm Sissel Jentoft Tone F Gregers Kjetill S Jakobsen |
author_facet |
Martin Malmstrøm Sissel Jentoft Tone F Gregers Kjetill S Jakobsen |
author_sort |
Martin Malmstrøm |
title |
Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy. |
title_short |
Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy. |
title_full |
Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy. |
title_fullStr |
Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy. |
title_full_unstemmed |
Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy. |
title_sort |
unraveling the evolution of the atlantic cod's (gadus morhua l.) alternative immune strategy. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pone.0074004 https://doaj.org/article/fc7581d0cf0d44e6939170685a94814f |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
PLoS ONE, Vol 8, Iss 9, p e74004 (2013) |
op_relation |
http://europepmc.org/articles/PMC3760826?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0074004 https://doaj.org/article/fc7581d0cf0d44e6939170685a94814f |
op_doi |
https://doi.org/10.1371/journal.pone.0074004 |
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PLoS ONE |
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8 |
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9 |
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e74004 |
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