Implementation approaches for leprosy prevention with single-dose rifampicin: A support tool for decision making.
Background In the past 15 years, the decline in annually detected leprosy patients has stagnated. To reduce the transmission of Mycobacterium leprae, the World Health Organization recommends single-dose rifampicin (SDR) as post-exposure prophylaxis (PEP) for contacts of leprosy patients. Various app...
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ftdoajarticles:oai:doaj.org/article:fc50450ae5a54a7d97d4d721380907f1 2023-05-15T15:14:53+02:00 Implementation approaches for leprosy prevention with single-dose rifampicin: A support tool for decision making. Fleur Ter Ellen Kaat Tielens Christine Fenenga Liesbeth Mieras Anne Schoenmakers Mohammad A Arif Nienke Veldhuijzen Ruth Peters Eliane Ignotti Christa Kasang Benedict Quao Peter Steinmann Nand Lal Banstola Joshua Oraga Teky Budiawan 2022-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010792 https://doaj.org/article/fc50450ae5a54a7d97d4d721380907f1 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010792 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010792 https://doaj.org/article/fc50450ae5a54a7d97d4d721380907f1 PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010792 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010792 2022-12-30T19:39:34Z Background In the past 15 years, the decline in annually detected leprosy patients has stagnated. To reduce the transmission of Mycobacterium leprae, the World Health Organization recommends single-dose rifampicin (SDR) as post-exposure prophylaxis (PEP) for contacts of leprosy patients. Various approaches to administer SDR-PEP have been piloted. However, requirements and criteria to select the most suitable approach were missing. The aims of this study were to develop an evidence-informed decision tool to support leprosy programme managers in selecting an SDR-PEP implementation approach, and to assess its user-friendliness among stakeholders without SDR-PEP experience. Methodology The development process comprised two phases. First, a draft tool was developed based on a literature review and semi-structured interviews with experts from various countries, organisations and institutes. This led to: an overview of existing SDR-PEP approaches and their characteristics; understanding the requirements and best circumstances for these approaches; and, identification of relevant criteria to select an approach. In the second phase the tool's usability and applicability was assessed, through interviews and a focus group discussion with intended, inexperienced users; leprosy programme managers and non-governmental organization (NGO) staff. Principal findings Five SDR-PEP implementation approaches were identified. The levels of endemicity and stigma, and the accessibility of an area were identified as most relevant criteria to select an approach. There was an information gap on cost-effectiveness, while successful implementation depends on availability of resources. Five basic requirements, irrespective of the approach, were identified: stakeholder support; availability of medication; compliant health system; trained health staff; and health education. Two added benefits of the tool were identified: its potential value for advocacy and for training. Conclusion An evidence-informed SDR-PEP decision tool to support the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 10 e0010792 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Fleur Ter Ellen Kaat Tielens Christine Fenenga Liesbeth Mieras Anne Schoenmakers Mohammad A Arif Nienke Veldhuijzen Ruth Peters Eliane Ignotti Christa Kasang Benedict Quao Peter Steinmann Nand Lal Banstola Joshua Oraga Teky Budiawan Implementation approaches for leprosy prevention with single-dose rifampicin: A support tool for decision making. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background In the past 15 years, the decline in annually detected leprosy patients has stagnated. To reduce the transmission of Mycobacterium leprae, the World Health Organization recommends single-dose rifampicin (SDR) as post-exposure prophylaxis (PEP) for contacts of leprosy patients. Various approaches to administer SDR-PEP have been piloted. However, requirements and criteria to select the most suitable approach were missing. The aims of this study were to develop an evidence-informed decision tool to support leprosy programme managers in selecting an SDR-PEP implementation approach, and to assess its user-friendliness among stakeholders without SDR-PEP experience. Methodology The development process comprised two phases. First, a draft tool was developed based on a literature review and semi-structured interviews with experts from various countries, organisations and institutes. This led to: an overview of existing SDR-PEP approaches and their characteristics; understanding the requirements and best circumstances for these approaches; and, identification of relevant criteria to select an approach. In the second phase the tool's usability and applicability was assessed, through interviews and a focus group discussion with intended, inexperienced users; leprosy programme managers and non-governmental organization (NGO) staff. Principal findings Five SDR-PEP implementation approaches were identified. The levels of endemicity and stigma, and the accessibility of an area were identified as most relevant criteria to select an approach. There was an information gap on cost-effectiveness, while successful implementation depends on availability of resources. Five basic requirements, irrespective of the approach, were identified: stakeholder support; availability of medication; compliant health system; trained health staff; and health education. Two added benefits of the tool were identified: its potential value for advocacy and for training. Conclusion An evidence-informed SDR-PEP decision tool to support the ... |
format |
Article in Journal/Newspaper |
author |
Fleur Ter Ellen Kaat Tielens Christine Fenenga Liesbeth Mieras Anne Schoenmakers Mohammad A Arif Nienke Veldhuijzen Ruth Peters Eliane Ignotti Christa Kasang Benedict Quao Peter Steinmann Nand Lal Banstola Joshua Oraga Teky Budiawan |
author_facet |
Fleur Ter Ellen Kaat Tielens Christine Fenenga Liesbeth Mieras Anne Schoenmakers Mohammad A Arif Nienke Veldhuijzen Ruth Peters Eliane Ignotti Christa Kasang Benedict Quao Peter Steinmann Nand Lal Banstola Joshua Oraga Teky Budiawan |
author_sort |
Fleur Ter Ellen |
title |
Implementation approaches for leprosy prevention with single-dose rifampicin: A support tool for decision making. |
title_short |
Implementation approaches for leprosy prevention with single-dose rifampicin: A support tool for decision making. |
title_full |
Implementation approaches for leprosy prevention with single-dose rifampicin: A support tool for decision making. |
title_fullStr |
Implementation approaches for leprosy prevention with single-dose rifampicin: A support tool for decision making. |
title_full_unstemmed |
Implementation approaches for leprosy prevention with single-dose rifampicin: A support tool for decision making. |
title_sort |
implementation approaches for leprosy prevention with single-dose rifampicin: a support tool for decision making. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010792 https://doaj.org/article/fc50450ae5a54a7d97d4d721380907f1 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010792 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010792 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010792 https://doaj.org/article/fc50450ae5a54a7d97d4d721380907f1 |
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https://doi.org/10.1371/journal.pntd.0010792 |
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PLOS Neglected Tropical Diseases |
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