Sequence Variability of pXO1-Located Pathogenicity Genes of Bacillus anthracis Natural Strains of Different Geographic Origin

• Published in: Pathogens
• Main Authors: Yulia Goncharova, Irina Bahtejeva, Galina Titareva, Tatiana Kravchenko, Anastasia Lev, Ivan Dyatlov, Vitalii Timofeev
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI AG 2021
• Subjects: Bacillus anthracis; pathogenicity factors; genotyping; Medicine; R; Arctic; Paga
• Online Access: https://doi.org/10.3390/pathogens10121556; https://doaj.org/article/fc1aa2cb4bb54895b1537668fcbde10b

The main pathogenic factor of Bacillus anthracis is a three-component toxin encoded by the pagA , lef , and cya genes, which are located on the pXO1 plasmid. The atxA gene, which encodes the primary regulator of pathogenicity factor expression, is located on the same plasmid. In this work, we evalua...