Atlantic cod piscidin and its diversification through positive selection.
Piscidins constitute a family of cationic antimicrobial peptides that are thought to play an important role in the innate immune response of teleosts. On the one hand they show a remarkable diversity, which indicates that they are shaped by positive selection, but on the other hand they are ancient...
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ftdoajarticles:oai:doaj.org/article:fc00f4bad0044eb0adf98665e369bd6a 2023-05-15T15:27:11+02:00 Atlantic cod piscidin and its diversification through positive selection. Jorge M O Fernandes Jareeporn Ruangsri Viswanath Kiron 2010-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0009501 https://doaj.org/article/fc00f4bad0044eb0adf98665e369bd6a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2830478?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0009501 https://doaj.org/article/fc00f4bad0044eb0adf98665e369bd6a PLoS ONE, Vol 5, Iss 3, p e9501 (2010) Medicine R Science Q article 2010 ftdoajarticles https://doi.org/10.1371/journal.pone.0009501 2022-12-31T09:31:02Z Piscidins constitute a family of cationic antimicrobial peptides that are thought to play an important role in the innate immune response of teleosts. On the one hand they show a remarkable diversity, which indicates that they are shaped by positive selection, but on the other hand they are ancient and have specific targets, suggesting that they are constrained by purifying selection. Until now piscidins had only been found in fish species from the superorder Acanthopterygii but we have recently identified a piscidin gene in Atlantic cod (Gadus morhua), thus showing that these antimicrobial peptides are not restricted to evolutionarily modern teleosts. Nucleotide diversity was much higher in the regions of the piscidin gene that code for the mature peptide and its pro domain than in the signal peptide. Maximum likelihood analyses with different evolution models revealed that the piscidin gene is under positive selection. Charge or hydrophobicity-changing amino acid substitutions observed in positively selected sites within the mature peptide influence its amphipathic structure and can have a marked effect on its function. This diversification might be associated with adaptation to new habitats or rapidly evolving pathogens. Article in Journal/Newspaper atlantic cod Gadus morhua Directory of Open Access Journals: DOAJ Articles PLoS ONE 5 3 e9501 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Medicine R Science Q |
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Medicine R Science Q Jorge M O Fernandes Jareeporn Ruangsri Viswanath Kiron Atlantic cod piscidin and its diversification through positive selection. |
topic_facet |
Medicine R Science Q |
description |
Piscidins constitute a family of cationic antimicrobial peptides that are thought to play an important role in the innate immune response of teleosts. On the one hand they show a remarkable diversity, which indicates that they are shaped by positive selection, but on the other hand they are ancient and have specific targets, suggesting that they are constrained by purifying selection. Until now piscidins had only been found in fish species from the superorder Acanthopterygii but we have recently identified a piscidin gene in Atlantic cod (Gadus morhua), thus showing that these antimicrobial peptides are not restricted to evolutionarily modern teleosts. Nucleotide diversity was much higher in the regions of the piscidin gene that code for the mature peptide and its pro domain than in the signal peptide. Maximum likelihood analyses with different evolution models revealed that the piscidin gene is under positive selection. Charge or hydrophobicity-changing amino acid substitutions observed in positively selected sites within the mature peptide influence its amphipathic structure and can have a marked effect on its function. This diversification might be associated with adaptation to new habitats or rapidly evolving pathogens. |
format |
Article in Journal/Newspaper |
author |
Jorge M O Fernandes Jareeporn Ruangsri Viswanath Kiron |
author_facet |
Jorge M O Fernandes Jareeporn Ruangsri Viswanath Kiron |
author_sort |
Jorge M O Fernandes |
title |
Atlantic cod piscidin and its diversification through positive selection. |
title_short |
Atlantic cod piscidin and its diversification through positive selection. |
title_full |
Atlantic cod piscidin and its diversification through positive selection. |
title_fullStr |
Atlantic cod piscidin and its diversification through positive selection. |
title_full_unstemmed |
Atlantic cod piscidin and its diversification through positive selection. |
title_sort |
atlantic cod piscidin and its diversification through positive selection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pone.0009501 https://doaj.org/article/fc00f4bad0044eb0adf98665e369bd6a |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
PLoS ONE, Vol 5, Iss 3, p e9501 (2010) |
op_relation |
http://europepmc.org/articles/PMC2830478?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0009501 https://doaj.org/article/fc00f4bad0044eb0adf98665e369bd6a |
op_doi |
https://doi.org/10.1371/journal.pone.0009501 |
container_title |
PLoS ONE |
container_volume |
5 |
container_issue |
3 |
container_start_page |
e9501 |
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1766357633829175296 |