Strategies to Overcome Antileishmanial Drugs Unresponsiveness
In the absence of effective vector control measures and vaccines against leishmaniasis, effective chemotherapy remains the mainstay of treatment. As the armoury of antileishmanial drugs is limited, strategies should be made to target the emergence of drug resistance. The loss of efficacy of antimoni...
Published in: | Journal of Tropical Medicine |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2014
|
Subjects: | |
Online Access: | https://doi.org/10.1155/2014/646932 https://doaj.org/article/fbf1a3876227407abb63dd7ed9935eb4 |
id |
ftdoajarticles:oai:doaj.org/article:fbf1a3876227407abb63dd7ed9935eb4 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:fbf1a3876227407abb63dd7ed9935eb4 2024-09-09T19:25:38+00:00 Strategies to Overcome Antileishmanial Drugs Unresponsiveness Shyam Sundar Anup Singh Om Prakash Singh 2014-01-01T00:00:00Z https://doi.org/10.1155/2014/646932 https://doaj.org/article/fbf1a3876227407abb63dd7ed9935eb4 EN eng Wiley http://dx.doi.org/10.1155/2014/646932 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2014/646932 https://doaj.org/article/fbf1a3876227407abb63dd7ed9935eb4 Journal of Tropical Medicine, Vol 2014 (2014) Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.1155/2014/646932 2024-08-05T17:48:42Z In the absence of effective vector control measures and vaccines against leishmaniasis, effective chemotherapy remains the mainstay of treatment. As the armoury of antileishmanial drugs is limited, strategies should be made to target the emergence of drug resistance. The loss of efficacy of antimonials such as sodium stibogluconate in the Indian subcontinent which has been the mainstay of treatment for more than six decades has raised concern to save the other drugs. In the current review, we highlight various steps which could be implemented to halt the increasing unresponsiveness of drugs such as monitoring of therapy in the form of rational dosing and duration of treatment, understanding the mechanism of action of the drugs and drug resistance, identification of markers of resistance, distribution of drugs free of cost, evolution of effective combination therapy and immunotherapy, and proper management of HIV/VL coinfection and post-kala-azar dermal leishmaniasis (PKDL). Strong support from governmental agencies and local communities in the form of education and orientation programmes for feasibility of implementing these strategies and affordability within the context of their health systems is needed in controlling and preventing leishmaniasis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Azar ENVELOPE(-63.733,-63.733,-64.983,-64.983) Indian Journal of Tropical Medicine 2014 1 7 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Shyam Sundar Anup Singh Om Prakash Singh Strategies to Overcome Antileishmanial Drugs Unresponsiveness |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
In the absence of effective vector control measures and vaccines against leishmaniasis, effective chemotherapy remains the mainstay of treatment. As the armoury of antileishmanial drugs is limited, strategies should be made to target the emergence of drug resistance. The loss of efficacy of antimonials such as sodium stibogluconate in the Indian subcontinent which has been the mainstay of treatment for more than six decades has raised concern to save the other drugs. In the current review, we highlight various steps which could be implemented to halt the increasing unresponsiveness of drugs such as monitoring of therapy in the form of rational dosing and duration of treatment, understanding the mechanism of action of the drugs and drug resistance, identification of markers of resistance, distribution of drugs free of cost, evolution of effective combination therapy and immunotherapy, and proper management of HIV/VL coinfection and post-kala-azar dermal leishmaniasis (PKDL). Strong support from governmental agencies and local communities in the form of education and orientation programmes for feasibility of implementing these strategies and affordability within the context of their health systems is needed in controlling and preventing leishmaniasis. |
format |
Article in Journal/Newspaper |
author |
Shyam Sundar Anup Singh Om Prakash Singh |
author_facet |
Shyam Sundar Anup Singh Om Prakash Singh |
author_sort |
Shyam Sundar |
title |
Strategies to Overcome Antileishmanial Drugs Unresponsiveness |
title_short |
Strategies to Overcome Antileishmanial Drugs Unresponsiveness |
title_full |
Strategies to Overcome Antileishmanial Drugs Unresponsiveness |
title_fullStr |
Strategies to Overcome Antileishmanial Drugs Unresponsiveness |
title_full_unstemmed |
Strategies to Overcome Antileishmanial Drugs Unresponsiveness |
title_sort |
strategies to overcome antileishmanial drugs unresponsiveness |
publisher |
Wiley |
publishDate |
2014 |
url |
https://doi.org/10.1155/2014/646932 https://doaj.org/article/fbf1a3876227407abb63dd7ed9935eb4 |
long_lat |
ENVELOPE(-63.733,-63.733,-64.983,-64.983) |
geographic |
Arctic Azar Indian |
geographic_facet |
Arctic Azar Indian |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2014 (2014) |
op_relation |
http://dx.doi.org/10.1155/2014/646932 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2014/646932 https://doaj.org/article/fbf1a3876227407abb63dd7ed9935eb4 |
op_doi |
https://doi.org/10.1155/2014/646932 |
container_title |
Journal of Tropical Medicine |
container_volume |
2014 |
container_start_page |
1 |
op_container_end_page |
7 |
_version_ |
1809895400205713408 |