Riesgo de sesgo de publicación en intervenciones terapéuticas para la COVID-19
This article describes publication bias, its most frequent causes, its characteristics, the regulatory tools to avoid it, and some statistical techniques to analyze it. These techniques are explained and applied to three therapeutic interventions related to the 2019 coronavirus disease (COVID-19): c...
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ftdoajarticles:oai:doaj.org/article:fbd6e5f3285346dd8fe7c6ce5db5963b 2023-05-15T15:10:45+02:00 Riesgo de sesgo de publicación en intervenciones terapéuticas para la COVID-19 Santiago Hasdeu Fernando Tortosa 2021-12-01T00:00:00Z https://doi.org/10.26633/RPSP.2021.157 https://doaj.org/article/fbd6e5f3285346dd8fe7c6ce5db5963b EN ES PT eng spa por Pan American Health Organization https://iris.paho.org/handle/10665.2/55364 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2021.157 https://doaj.org/article/fbd6e5f3285346dd8fe7c6ce5db5963b Revista Panamericana de Salud Pública, Vol 45, Iss 157, Pp 1-8 (2021) meta-analysis as topic systematic review publication bias covid-19 technology assessment biomedical Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.26633/RPSP.2021.157 2022-12-31T04:25:48Z This article describes publication bias, its most frequent causes, its characteristics, the regulatory tools to avoid it, and some statistical techniques to analyze it. These techniques are explained and applied to three therapeutic interventions related to the 2019 coronavirus disease (COVID-19): corticosteroids, ivermectin, and tocilizumab. Risk of publication bias was detected for ivermectin and tocilizumab. Systematic reviews and meta-analyses are secondary research designs that provide a reference to guide decision-making. They are prone to different types of bias, i.e., a systematic deviation in the results. Even if carried out with methodological rigor, their validity can be threatened by publication bias. This is defined as the act of concealing or delaying publication, withholding data arising from research studies, or both. Up to half of controlled trials remain unpublished. During the H1N1 virus pandemic, publication bias from industry-funded studies led to the recommendation and large-scale procurement of oseltamivir, a drug that later proved to have no relevant beneficial effects. Two-thirds of clinical trial funding for COVID-19 comes from the pharmaceutical industry. In the context of the COVID-19 pandemic, studies are published at an accelerated pace, making it very important to understand and identify publication bias. To reduce publication bias it is necessary to regulate the registration and publication of clinical trials, but this requires coordination among countries and international bodies. It is important to suspect and attempt to identify publication bias for decision making. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud Pública 45 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
meta-analysis as topic systematic review publication bias covid-19 technology assessment biomedical Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
meta-analysis as topic systematic review publication bias covid-19 technology assessment biomedical Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Santiago Hasdeu Fernando Tortosa Riesgo de sesgo de publicación en intervenciones terapéuticas para la COVID-19 |
topic_facet |
meta-analysis as topic systematic review publication bias covid-19 technology assessment biomedical Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
This article describes publication bias, its most frequent causes, its characteristics, the regulatory tools to avoid it, and some statistical techniques to analyze it. These techniques are explained and applied to three therapeutic interventions related to the 2019 coronavirus disease (COVID-19): corticosteroids, ivermectin, and tocilizumab. Risk of publication bias was detected for ivermectin and tocilizumab. Systematic reviews and meta-analyses are secondary research designs that provide a reference to guide decision-making. They are prone to different types of bias, i.e., a systematic deviation in the results. Even if carried out with methodological rigor, their validity can be threatened by publication bias. This is defined as the act of concealing or delaying publication, withholding data arising from research studies, or both. Up to half of controlled trials remain unpublished. During the H1N1 virus pandemic, publication bias from industry-funded studies led to the recommendation and large-scale procurement of oseltamivir, a drug that later proved to have no relevant beneficial effects. Two-thirds of clinical trial funding for COVID-19 comes from the pharmaceutical industry. In the context of the COVID-19 pandemic, studies are published at an accelerated pace, making it very important to understand and identify publication bias. To reduce publication bias it is necessary to regulate the registration and publication of clinical trials, but this requires coordination among countries and international bodies. It is important to suspect and attempt to identify publication bias for decision making. |
format |
Article in Journal/Newspaper |
author |
Santiago Hasdeu Fernando Tortosa |
author_facet |
Santiago Hasdeu Fernando Tortosa |
author_sort |
Santiago Hasdeu |
title |
Riesgo de sesgo de publicación en intervenciones terapéuticas para la COVID-19 |
title_short |
Riesgo de sesgo de publicación en intervenciones terapéuticas para la COVID-19 |
title_full |
Riesgo de sesgo de publicación en intervenciones terapéuticas para la COVID-19 |
title_fullStr |
Riesgo de sesgo de publicación en intervenciones terapéuticas para la COVID-19 |
title_full_unstemmed |
Riesgo de sesgo de publicación en intervenciones terapéuticas para la COVID-19 |
title_sort |
riesgo de sesgo de publicación en intervenciones terapéuticas para la covid-19 |
publisher |
Pan American Health Organization |
publishDate |
2021 |
url |
https://doi.org/10.26633/RPSP.2021.157 https://doaj.org/article/fbd6e5f3285346dd8fe7c6ce5db5963b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 45, Iss 157, Pp 1-8 (2021) |
op_relation |
https://iris.paho.org/handle/10665.2/55364 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2021.157 https://doaj.org/article/fbd6e5f3285346dd8fe7c6ce5db5963b |
op_doi |
https://doi.org/10.26633/RPSP.2021.157 |
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Revista Panamericana de Salud Pública |
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45 |
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