Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging
The complex pathogenesis of Alzheimer's disease (AD) leads to a limited therapeutic effect; therefore, the combination of multiple bioactive ingredients may be more effective in improving AD due to synergistic effects. Based on the perspective of the sea–land combination, the effects of sea-der...
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ftdoajarticles:oai:doaj.org/article:fbc3785c543d4558a711f51a6b1956e4 2023-05-15T14:03:33+02:00 Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging Cheng-Cheng Wang Jing-Ya Kong Xiao-Yue Li Jin-Yue Yang Chang-Hu Xue Teruyoshi Yanagita Yu-Ming Wang 2022-09-01T00:00:00Z https://doi.org/10.3389/fnagi.2022.964077 https://doaj.org/article/fbc3785c543d4558a711f51a6b1956e4 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fnagi.2022.964077/full https://doaj.org/toc/1663-4365 1663-4365 doi:10.3389/fnagi.2022.964077 https://doaj.org/article/fbc3785c543d4558a711f51a6b1956e4 Frontiers in Aging Neuroscience, Vol 14 (2022) sea–land combination neurodegenerative diseases Antarctic krill oil nobiletin theanine n-3 PUFAs-enriched phospholipids Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 article 2022 ftdoajarticles https://doi.org/10.3389/fnagi.2022.964077 2022-12-30T20:35:27Z The complex pathogenesis of Alzheimer's disease (AD) leads to a limited therapeutic effect; therefore, the combination of multiple bioactive ingredients may be more effective in improving AD due to synergistic effects. Based on the perspective of the sea–land combination, the effects of sea-derived Antarctic krill oil (AKO) combined with land-derived nobiletin (Nob) and L-theanine (The) on memory loss and cognitive deficiency were studied in senescence-accelerated prone 8 mice (SAMP8). The results demonstrated that AKO combined with The significantly increased the number of platform crossings in the Morris water maze test by 1.6-fold, and AKO combined with Nob significantly increased the preference index in a novel object recognition test. AKO exhibited synergistic effects with Nob and The in ameliorating recognition memory and spatial memory deficiency in SAMP8 mice, respectively. Further research of the mechanism indicated that AKO exhibited synergistic effects with Nob in suppressing β-amyloid (Aβ) aggregation, neurofibrillary tangles, and apoptosis and neuroinflammation, while the synergistic effects of AKO and The involved in synaptic plasticity and anti-neuroinflammation, which revealed that the combination was complex, not a mechanical addition. These findings revealed that the sea–land combination may be an effective strategy to treat and alleviate AD. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Directory of Open Access Journals: DOAJ Articles Antarctic Frontiers in Aging Neuroscience 14 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
sea–land combination neurodegenerative diseases Antarctic krill oil nobiletin theanine n-3 PUFAs-enriched phospholipids Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
spellingShingle |
sea–land combination neurodegenerative diseases Antarctic krill oil nobiletin theanine n-3 PUFAs-enriched phospholipids Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Cheng-Cheng Wang Jing-Ya Kong Xiao-Yue Li Jin-Yue Yang Chang-Hu Xue Teruyoshi Yanagita Yu-Ming Wang Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
topic_facet |
sea–land combination neurodegenerative diseases Antarctic krill oil nobiletin theanine n-3 PUFAs-enriched phospholipids Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
description |
The complex pathogenesis of Alzheimer's disease (AD) leads to a limited therapeutic effect; therefore, the combination of multiple bioactive ingredients may be more effective in improving AD due to synergistic effects. Based on the perspective of the sea–land combination, the effects of sea-derived Antarctic krill oil (AKO) combined with land-derived nobiletin (Nob) and L-theanine (The) on memory loss and cognitive deficiency were studied in senescence-accelerated prone 8 mice (SAMP8). The results demonstrated that AKO combined with The significantly increased the number of platform crossings in the Morris water maze test by 1.6-fold, and AKO combined with Nob significantly increased the preference index in a novel object recognition test. AKO exhibited synergistic effects with Nob and The in ameliorating recognition memory and spatial memory deficiency in SAMP8 mice, respectively. Further research of the mechanism indicated that AKO exhibited synergistic effects with Nob in suppressing β-amyloid (Aβ) aggregation, neurofibrillary tangles, and apoptosis and neuroinflammation, while the synergistic effects of AKO and The involved in synaptic plasticity and anti-neuroinflammation, which revealed that the combination was complex, not a mechanical addition. These findings revealed that the sea–land combination may be an effective strategy to treat and alleviate AD. |
format |
Article in Journal/Newspaper |
author |
Cheng-Cheng Wang Jing-Ya Kong Xiao-Yue Li Jin-Yue Yang Chang-Hu Xue Teruyoshi Yanagita Yu-Ming Wang |
author_facet |
Cheng-Cheng Wang Jing-Ya Kong Xiao-Yue Li Jin-Yue Yang Chang-Hu Xue Teruyoshi Yanagita Yu-Ming Wang |
author_sort |
Cheng-Cheng Wang |
title |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_short |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_full |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_fullStr |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_full_unstemmed |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_sort |
antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in samp8 mice: applying the perspective of the sea–land combination to retard brain aging |
publisher |
Frontiers Media S.A. |
publishDate |
2022 |
url |
https://doi.org/10.3389/fnagi.2022.964077 https://doaj.org/article/fbc3785c543d4558a711f51a6b1956e4 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_source |
Frontiers in Aging Neuroscience, Vol 14 (2022) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fnagi.2022.964077/full https://doaj.org/toc/1663-4365 1663-4365 doi:10.3389/fnagi.2022.964077 https://doaj.org/article/fbc3785c543d4558a711f51a6b1956e4 |
op_doi |
https://doi.org/10.3389/fnagi.2022.964077 |
container_title |
Frontiers in Aging Neuroscience |
container_volume |
14 |
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1766274236336308224 |