Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Paulo Marcos Z. Coelho, Pedro Raso, Rômulo Teixeira de Mello, Nivaldo H. Toppa
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1994
• Subjects: Sçhistosoma mansoni; Granuloma; Tratamento quimioterápico; Modulação da resposta granulomatosa; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86821994000300001; https://doaj.org/article/fba89cc3f68f464dbc1a0d1325edabc8

Mice previously infected with Schistosoma mansoni, and cured by specific treatment (400mg/kg oxamniquine, p. o.) in the chronic phase of the disease, were reinfected 20 days after treatment to assess their capacityfor modulation ofthe granulomatous response. Histopathologic examination of the animals ' liver, at 60 days after reinfection, evidenced the presence of typical granulomas of the chronic phase in most animals. This infer that the capacity for modulation of the granulomatous response had been maintained, thus preventing a new acute phase of the disease. Conversely, a group of previously infected mice, untreated and submitted to reinfection, showed reactivation of the granulomatous response in 50% of the animals. The possible implications of these findings in human schistosomiasis mansoni are discussed.