Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice.
Zika virus (ZIKV) falls into two lineages: African (ZIKVAF) and Asian (ZIKVAS). These lineages have not been tested comprehensively in parallel for disease progression using an animal model system. Here, using the established type-I interferon receptor knockout (A129) mouse model, it is first demons...
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ftdoajarticles:oai:doaj.org/article:fb986a16fcc047c78acc6d50aeed3000 2023-05-15T15:04:00+02:00 Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. Stuart D Dowall Victoria A Graham Emma Rayner Laura Hunter Barry Atkinson Geoff Pearson Mike Dennis Roger Hewson 2017-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005704 https://doaj.org/article/fb986a16fcc047c78acc6d50aeed3000 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5510909?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005704 https://doaj.org/article/fb986a16fcc047c78acc6d50aeed3000 PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005704 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005704 2022-12-31T02:16:02Z Zika virus (ZIKV) falls into two lineages: African (ZIKVAF) and Asian (ZIKVAS). These lineages have not been tested comprehensively in parallel for disease progression using an animal model system. Here, using the established type-I interferon receptor knockout (A129) mouse model, it is first demonstrated that ZIKVAF causes lethal infection, with different kinetics of disease manifestations according to the challenge dose. Animals challenged with a low dose of 10 plaque-forming units (pfu) developed more neurological symptoms than those challenged with 5-log higher doses. By contrast, animals challenged with ZIKVAS displayed no clinical signs or mortality, even at doses of 106 pfu. However, viral RNA was detected in the tissues of animals infected with ZIKV strains from both lineages and similar histological changes were observed. The present study highlights strain specific virulence differences between the African and Asian lineages in a ZIKV mouse model. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 7 e0005704 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Stuart D Dowall Victoria A Graham Emma Rayner Laura Hunter Barry Atkinson Geoff Pearson Mike Dennis Roger Hewson Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Zika virus (ZIKV) falls into two lineages: African (ZIKVAF) and Asian (ZIKVAS). These lineages have not been tested comprehensively in parallel for disease progression using an animal model system. Here, using the established type-I interferon receptor knockout (A129) mouse model, it is first demonstrated that ZIKVAF causes lethal infection, with different kinetics of disease manifestations according to the challenge dose. Animals challenged with a low dose of 10 plaque-forming units (pfu) developed more neurological symptoms than those challenged with 5-log higher doses. By contrast, animals challenged with ZIKVAS displayed no clinical signs or mortality, even at doses of 106 pfu. However, viral RNA was detected in the tissues of animals infected with ZIKV strains from both lineages and similar histological changes were observed. The present study highlights strain specific virulence differences between the African and Asian lineages in a ZIKV mouse model. |
format |
Article in Journal/Newspaper |
author |
Stuart D Dowall Victoria A Graham Emma Rayner Laura Hunter Barry Atkinson Geoff Pearson Mike Dennis Roger Hewson |
author_facet |
Stuart D Dowall Victoria A Graham Emma Rayner Laura Hunter Barry Atkinson Geoff Pearson Mike Dennis Roger Hewson |
author_sort |
Stuart D Dowall |
title |
Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. |
title_short |
Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. |
title_full |
Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. |
title_fullStr |
Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. |
title_full_unstemmed |
Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. |
title_sort |
lineage-dependent differences in the disease progression of zika virus infection in type-i interferon receptor knockout (a129) mice. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005704 https://doaj.org/article/fb986a16fcc047c78acc6d50aeed3000 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005704 (2017) |
op_relation |
http://europepmc.org/articles/PMC5510909?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005704 https://doaj.org/article/fb986a16fcc047c78acc6d50aeed3000 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005704 |
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PLOS Neglected Tropical Diseases |
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11 |
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7 |
container_start_page |
e0005704 |
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1766335833103663104 |