Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea
The gonads of sea urchins have been consumed by humans since ancient times. However, relatively little information is available on their biological activity. In the present study, we have consecutively extracted gonads of green sea urchins Strongylocentrotus droebachiensis from Barents Sea with chlo...
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ftdoajarticles:oai:doaj.org/article:fb609024821f499eb9161905551185f3 2023-05-15T15:38:39+02:00 Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea Olga N. Pozharitskaya Alexander N. Shikov Into Laakso Tuulikki Seppänen-Laakso Igor E. Makarenko Natalya M. Faustova Marina N. Makarova Valery G. Makarov 2015-08-01T00:00:00Z https://doi.org/10.1016/j.jff.2015.05.030 https://doaj.org/article/fb609024821f499eb9161905551185f3 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1756464615002686 https://doaj.org/toc/1756-4646 1756-4646 doi:10.1016/j.jff.2015.05.030 https://doaj.org/article/fb609024821f499eb9161905551185f3 Journal of Functional Foods, Vol 17, Iss , Pp 227-234 (2015) Strongylocentrotus droebachiensis Gonads Cyclooxygenase Diabetes Dipeptidyl peptidase IV Echinenone Nutrition. Foods and food supply TX341-641 article 2015 ftdoajarticles https://doi.org/10.1016/j.jff.2015.05.030 2022-12-31T06:10:03Z The gonads of sea urchins have been consumed by humans since ancient times. However, relatively little information is available on their biological activity. In the present study, we have consecutively extracted gonads of green sea urchins Strongylocentrotus droebachiensis from Barents Sea with chloroform-95% EtOH (4:1, v/v), (fraction ESD1), 95% EtOH (ESD2), and 70% EtOH (ESD3), characterized the fractions by GC-MS and HPLC, and further investigated their bioactivities.The cyclooxygenase-2 was inhibited by 62% with ESD1 and by 39% with ESD2. All the extracts from gonads significantly prevented the decrease in body weight of mice having streptozotocin–nicotinamide-induced (STZ/NA) diabetes. ESD2 significantly reduced serum glucose level in mice after 5 days of administration. The 50% inhibition of dipeptidyl peptidase IV was observed at a dose of 20 µg/ml of ESD2. These results suggest that sea urchin gonads may serve as a functional food for the management of inflammatory diseases and diabetes. Article in Journal/Newspaper Barents Sea Directory of Open Access Journals: DOAJ Articles Barents Sea Journal of Functional Foods 17 227 234 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Strongylocentrotus droebachiensis Gonads Cyclooxygenase Diabetes Dipeptidyl peptidase IV Echinenone Nutrition. Foods and food supply TX341-641 |
spellingShingle |
Strongylocentrotus droebachiensis Gonads Cyclooxygenase Diabetes Dipeptidyl peptidase IV Echinenone Nutrition. Foods and food supply TX341-641 Olga N. Pozharitskaya Alexander N. Shikov Into Laakso Tuulikki Seppänen-Laakso Igor E. Makarenko Natalya M. Faustova Marina N. Makarova Valery G. Makarov Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
topic_facet |
Strongylocentrotus droebachiensis Gonads Cyclooxygenase Diabetes Dipeptidyl peptidase IV Echinenone Nutrition. Foods and food supply TX341-641 |
description |
The gonads of sea urchins have been consumed by humans since ancient times. However, relatively little information is available on their biological activity. In the present study, we have consecutively extracted gonads of green sea urchins Strongylocentrotus droebachiensis from Barents Sea with chloroform-95% EtOH (4:1, v/v), (fraction ESD1), 95% EtOH (ESD2), and 70% EtOH (ESD3), characterized the fractions by GC-MS and HPLC, and further investigated their bioactivities.The cyclooxygenase-2 was inhibited by 62% with ESD1 and by 39% with ESD2. All the extracts from gonads significantly prevented the decrease in body weight of mice having streptozotocin–nicotinamide-induced (STZ/NA) diabetes. ESD2 significantly reduced serum glucose level in mice after 5 days of administration. The 50% inhibition of dipeptidyl peptidase IV was observed at a dose of 20 µg/ml of ESD2. These results suggest that sea urchin gonads may serve as a functional food for the management of inflammatory diseases and diabetes. |
format |
Article in Journal/Newspaper |
author |
Olga N. Pozharitskaya Alexander N. Shikov Into Laakso Tuulikki Seppänen-Laakso Igor E. Makarenko Natalya M. Faustova Marina N. Makarova Valery G. Makarov |
author_facet |
Olga N. Pozharitskaya Alexander N. Shikov Into Laakso Tuulikki Seppänen-Laakso Igor E. Makarenko Natalya M. Faustova Marina N. Makarova Valery G. Makarov |
author_sort |
Olga N. Pozharitskaya |
title |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_short |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_full |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_fullStr |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_full_unstemmed |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_sort |
bioactivity and chemical characterization of gonads of green sea urchin strongylocentrotus droebachiensis from barents sea |
publisher |
Elsevier |
publishDate |
2015 |
url |
https://doi.org/10.1016/j.jff.2015.05.030 https://doaj.org/article/fb609024821f499eb9161905551185f3 |
geographic |
Barents Sea |
geographic_facet |
Barents Sea |
genre |
Barents Sea |
genre_facet |
Barents Sea |
op_source |
Journal of Functional Foods, Vol 17, Iss , Pp 227-234 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1756464615002686 https://doaj.org/toc/1756-4646 1756-4646 doi:10.1016/j.jff.2015.05.030 https://doaj.org/article/fb609024821f499eb9161905551185f3 |
op_doi |
https://doi.org/10.1016/j.jff.2015.05.030 |
container_title |
Journal of Functional Foods |
container_volume |
17 |
container_start_page |
227 |
op_container_end_page |
234 |
_version_ |
1766369829933023232 |